(3-methoxybenzyl)(4-phenylbutyl)carbamic acid tert-butyl ester | 1392096-53-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3-methoxybenzyl)(4-phenylbutyl)carbamic acid tert-butyl ester
• 英文别名: tert-butyl N-[(3-methoxyphenyl)methyl]-N-(4-phenylbutyl)carbamate
• CAS: 1392096-53-5
• 化学式: C₂₃H₃₁NO₃
• 分子量: 369.504
• InChiKey: VERWNIYOBFKHEX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  27
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯基-4-丁胺 、 3-甲氧基苯甲醛 在 三乙酰氧基硼氢化钠 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 生成 (3-methoxybenzyl)(4-phenylbutyl)carbamic acid tert-butyl ester
  参考文献：
  名称：

  A one-pot selective synthesis of N-Boc protected secondary amines: tandem direct reductive amination/N-Boc protection

  摘要：

  A one-pot tandem direct reductive amination of aldehydes with primary amines resulting in N-Boc secondary amines using a (Boc)(2)O/sodium triacetoxyborohydride (STAB) system is reported. The tandem procedure is efficient, selective, and versatile, giving excellent yields of N-Boc protected secondary amines even in those cases where the products are prone to intramolecular lactamization. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.06.055

文献信息

• A one-pot selective synthesis of N-Boc protected secondary amines: tandem direct reductive amination/N-Boc protection
  作者：Raghupathi Neelarapu、Pavel A. Petukhov

  DOI：10.1016/j.tet.2012.06.055

  日期：2012.9

  A one-pot tandem direct reductive amination of aldehydes with primary amines resulting in N-Boc secondary amines using a (Boc)(2)O/sodium triacetoxyborohydride (STAB) system is reported. The tandem procedure is efficient, selective, and versatile, giving excellent yields of N-Boc protected secondary amines even in those cases where the products are prone to intramolecular lactamization. (C) 2012 Elsevier Ltd. All rights reserved.