methyl 3-(Methoxycarbonyl)-5-[(4-methylphenyl)carbonylamino]benzoate | 325981-27-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 3-(Methoxycarbonyl)-5-[(4-methylphenyl)carbonylamino]benzoate
• 英文别名: Dimethyl 5-[(4-methylbenzoyl)amino]isophthalate；dimethyl 5-[(4-methylbenzoyl)amino]benzene-1,3-dicarboxylate
• CAS: 325981-27-9
• 化学式: C₁₈H₁₇NO₅
• 分子量: 327.337
• InChiKey: OATUHJJOSYMAEF-UHFFFAOYSA-N

物化性质

• 沸点：
  416.7±45.0 °C(Predicted)
• 密度：
  1.257±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  81.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-氨基间苯二甲酸二甲酯 、 对甲基苯甲酰氯 在 N,N-二异丙基乙胺 作用下， 以 氯仿 、 乙酸乙酯 为溶剂， 生成 methyl 3-(Methoxycarbonyl)-5-[(4-methylphenyl)carbonylamino]benzoate
  参考文献：
  名称：

  Naphthylsulfonic acids and related compounds as glucose uptake agonists

  摘要：

  使用新型萘磺酸和相关化合物治疗与高血糖相关的疾病，特别是II型糖尿病的方法。这些化合物，作为单一立体异构体或立体异构体混合物，或它们的药用可接受盐，在刺激胰岛素受体的激酶活性、增强胰岛素对胰岛素受体的激活以及促进葡萄糖进入细胞的方法中具有用途。还披露了各种抗糖尿病化合物和包含这些抗糖尿病化合物的药物组合物。

  公开号：

  US06653321B1

文献信息

• Rhodium-Catalyzed Synthesis of Amides from Functionalized Blocked Isocyanates
  作者：Joshua S. Derasp、André M. Beauchemin

  DOI：10.1021/acscatal.9b02641

  日期：2019.9.6

  Isocyanates are useful building blocks for the synthesis of amides, although their widespread use has been limited by their high reactivity, which often results in poor functional group tolerance and a propensity to oligomerize. Herein, a rhodium-catalyzed synthesis of amides is described coupling boroxines with blocked (masked) isocyanates. The success of the reaction hinges on the ability to form

  异氰酸酯是酰胺合成的有用组成部分，尽管它们的广泛使用受到其高反应性的限制，这通常导致较差的官能团耐受性和低聚倾向。在本文中，描述了铑催化的酰胺的合成，其将环硼氧烷与封闭的（被掩蔽的）异氰酸酯偶联。反应的成功取决于原位形成异氰酸酯和有机铑中间体的能力。依赖于掩蔽的异氰酸酯前体和有机铑中间体的高反应性，可实现宽泛的官能团耐受性，包括质子亲核基团（如胺，苯胺和醇）。
• NAPHTHYLSULFONIC ACIDS AND RELATED COMPOUNDS AS GLUCOSE UPTAKE AGONISTS
  申请人：TELIK, INC.

  公开号：EP1200396A1

  公开（公告）日：2002-05-02
• US6653321B1
  申请人：——

  公开号：US6653321B1

  公开（公告）日：2003-11-25
• [EN] NOVEL NAPHTHYLSULFONIC ACIDS AND RELATED COMPOUNDS AS GLUCOSE UPTAKE AGONISTS<br/>[FR] NOUVEAUX ACIDES NAPHTYLSULFONIQUES ET COMPOSES APPARENTES UTILISES COMME AGONISTES DE CAPTAGE DU GLUCOSE
  申请人：TELIK INC

  公开号：WO2001012591A1

  公开（公告）日：2001-02-22

  Methods for treating conditions associated with hyperglycemia, especially Type II diabetes, with novel naphthylsulfonic acids and related compounds are provided. Compounds of formula (1) where: R?1 and R2¿ are, independently, hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, R3 is a substituent on the B ring; and is -SO¿2OR?6, -C(O)OR6, -SO2NR62-C(O)NR62 or tetrazolyl; the linker -WY- between the naphthyl and phenyl intersects the A ring of the naphthyl and is, independently, -C(O)NR?7-, -NR7¿C(O)-, -C(O)O-, -OC(O)-, -CH=CH-, -NR7CH2-, -CH2NR?7-, -NR7C(O)NR7- -NR7¿C(O)O-, -OC(O)NR?7-, -NR7SO¿2O-, -OSO2NR7-, -OC(O)O-, -SO¿2?NR?7-, -NR7SO¿2-, -OSO2-, or -SO2O-; each R?6 and R7¿ is, independently, hydrogen or lower alkyl; optionally in the form of single stereoisomers or mixtures of stereoisomers, or the pharmaceutically acceptable salts thereof; are useful in methods of stimulating the kinase activity of the insulin receptor, enhancing the activation of the insulin receptor by insulin, and stimulating the uptake of glucose into cells. A variety of antidiabetic compounds and pharmaceutical compositions comprising the antidiabetic compounds are also disclosed.
• Naphthylsulfonic acids and related compounds as glucose uptake agonists
  申请人：Telik, Inc.

  公开号：US06653321B1

  公开（公告）日：2003-11-25

  Methods for treating conditions associated with hyperglycemia, especially Type II diabetes, with novel naphthylsulfonic acids and related compounds. These compounds, as single stereoisomers or mixtures of stereoisomers, or their pharmaceutically acceptable salts, are useful in methods of stimulating the kinase activity of the insulin receptor, enhancing the activation of the insulin receptor by insulin, and stimulating the uptake of glucose into cells. A variety of antidiabetic compounds and pharmaceutical compositions comprising the antidiabetic compounds are also disclosed.

  使用新型萘磺酸和相关化合物治疗与高血糖相关的疾病，特别是II型糖尿病的方法。这些化合物，作为单一立体异构体或立体异构体混合物，或它们的药用可接受盐，在刺激胰岛素受体的激酶活性、增强胰岛素对胰岛素受体的激活以及促进葡萄糖进入细胞的方法中具有用途。还披露了各种抗糖尿病化合物和包含这些抗糖尿病化合物的药物组合物。