2H-咪唑并[4,5-d][1,3]恶唑并[5,4-b]吡啶 | 807364-33-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2H-咪唑并[4,5-d][1,3]恶唑并[5,4-b]吡啶
• 英文名称: 2H-Imidazo[4,5-D]oxazolo[5,4-B]pyridine
• 英文别名: 5-oxa-3,7,10,12-tetrazatricyclo[7.3.0.02,6]dodeca-1(12),2,6,8,10-pentaene
• CAS: 807364-33-6
• 化学式: C₇H₄N₄O
• 分子量: 160.13
• InChiKey: MSFJGXLEMGBVRF-UHFFFAOYSA-N

物化性质

• 沸点：
  302.4±25.0 °C(Predicted)
• 密度：
  1.88±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  58.7
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] IMIDAZO-FUSED OXAZOLO[4,5-B]PYRIDINE AND IMIDAZO-FUSED THIAZOLO[4,5-B]PYRIDINE BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME<br/>[FR] COMPOSES TRICYCLIQUES A BASE D'OXAZOLO[4,5-B]PYRIDINE CONDENSEE A UN IMIDAZO ET DE THIAZOLO[4,5-B]PYRIDINE CONDENSEE A UN IMIDAZO, ET COMPOSITIONS PHARMACEUTIQUES RENFERMANT CEUX-CI
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2004106293A2

  公开（公告）日：2004-12-09

  The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.