5-Chloro-3-(4-fluorophenyl)sulfanyl-2-phenyl-1-benzofuran

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: 5-Chloro-3-(4-fluorophenyl)sulfanyl-2-phenyl-1-benzofuran
• 英文别名: 5-chloro-3-(4-fluorophenyl)sulfanyl-2-phenyl-1-benzofuran
• 化学式: C₁₁H₁₄NO₃Pol
• 分子量: 354.8
• InChiKey: DODNAVRTRWDIKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  aminomethyl-terminated Tentagel resin 、 alkaline earth salt of/the/ methylsulfuric acid 在 1-羟基苯并三唑 、 N,N'-二异丙基碳二亚胺 、 sodium hydroxide 作用下， 以 1,4-二氧六环 、 水 为溶剂， 生成 5-Chloro-3-(4-fluorophenyl)sulfanyl-2-phenyl-1-benzofuran
  参考文献：
  名称：

  A generic small-molecule microarray immobilization strategy

  摘要：

  Small-molecule microarrays are often limited by the requirement for each compound undergoing immobilization to contain a common functional group or by the need to prepare glass slides containing photo-reactive groups. Herein, we present a generic strategy that allows any compound library to be immobilized. This was achieved by printing a fluorous-tagged photo-reactive 3-aryl-3-trifluoromethyldiazirine, which undergoes non-selective insertion into compounds following UV-activation, onto fluorous-functionalized glass slides. The arrays could be reused following aqueous stripping and re-assessment of the compounds with the same protein or another target of interest. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.10.055

文献信息

• Metal-free synthesis of 3-chalcogen benzo[b]furans via an iodine-mediated electrophilic cyclisation of 2-alkynylanisoles
  作者：Mei Xu、Xiao-Hong Zhang、Ping Zhong

  DOI：10.1016/j.tetlet.2011.10.045

  日期：2011.12

  An efficient and metal-free method was developed to synthesize 3-chalcogen benzo[b]furans via the iodine-mediated electrophilic cyclisation of 2-alkynylanisoles with disulfides or diselenides. In the presence of I2, various 3-sulfenylbenzofurans or 3-selenenylbenzofurans were obtained in moderate to high yields.

  通过用二硫化物或二硒化物通过碘介导的2-炔基茴香醚的亲电亲电环化反应，开发了一种高效且无金属的方法来合成3-硫属元素苯并[ b ]呋喃。在I 2的存在下，以中等至高产率获得了各种3-亚磺酰基苯并呋喃或3-硒代苯并呋喃。
• A generic small-molecule microarray immobilization strategy
  作者：Mariona Vallès-Miret、Mark Bradley

  DOI：10.1016/j.tetlet.2011.10.055

  日期：2011.12

  Small-molecule microarrays are often limited by the requirement for each compound undergoing immobilization to contain a common functional group or by the need to prepare glass slides containing photo-reactive groups. Herein, we present a generic strategy that allows any compound library to be immobilized. This was achieved by printing a fluorous-tagged photo-reactive 3-aryl-3-trifluoromethyldiazirine, which undergoes non-selective insertion into compounds following UV-activation, onto fluorous-functionalized glass slides. The arrays could be reused following aqueous stripping and re-assessment of the compounds with the same protein or another target of interest. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.