2,2'-dimethoxy-4,4'-biphenylenediisocyanate | 20210-82-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2'-dimethoxy-4,4'-biphenylenediisocyanate
• 英文别名: 2,2'-dimethoxy-biphenyl-4,4'-diyl diisocyanate；2,2'-Dimethoxy-biphenyl-4,4'-diyldiisocyanat；4-Isocyanato-1-(4-isocyanato-2-methoxyphenyl)-2-methoxybenzene
• CAS: 20210-82-6
• 化学式: C₁₆H₁₂N₂O₄
• 分子量: 296.282
• InChiKey: KGEWKKZUZPBYBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  77.3
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-(4-氯苯基)-1-氰基硫代甲酰胺 、 2,2'-dimethoxy-4,4'-biphenylenediisocyanate 在 三乙胺 作用下， 以 乙醚 为溶剂， 反应 0.42h， 生成 3,3'-(2,2'-dimethoxybiphenyl-4,4'-diyl)bis(1-(4-chlorophenyl)-4-imino-5-thioxoimidazolidin-2-one)
  参考文献：
  名称：

  双咪唑烷亚胺硫酮的合成与生物学评价：比较研究

  摘要：

  一系列 15 种新型对称和非对称双咪唑烷亚胺硫酮（6a-g、7a-e、8a、b 和 9）在 N-(1) 处具有各种取代基（对甲苯基、对甲氧基苯基、对乙氧基苯基） 、对氯苯基、对溴苯基、对碘苯基和 3,5-二氯苯基）以及 N-(3) 原子之间的不同连接体 [4,4'-氧双 (4,1-亚苯基), 2,2' -二甲氧基联苯和（1,3,3-三甲基环己基）甲基）]由取代的 N-芳基氰基硫代甲酰苯胺和各种双异氰酸酯以 65-75% 的产率制备。筛选对 HEPG2、HEP2、MCF7 和 HCT116 肿瘤细胞系的细胞毒性的 IC50 值范围为 6.3 至 84.6 µM，其中化合物 6b、d、e、g 和 7a 对至少一种细胞系具有显着活性，强调了匹配适当位置的取代基对 N-(1) 和适当的 N-(3)-N-(3) 接头的影响。同样地，所有杂环均针对微生物（铜绿假单胞菌、黄八叠球菌、短小芽孢杆菌和藤黄微

  DOI：

  10.1002/ardp.201300097

文献信息

• Synthesis, characterization, and derivatization of some novel types of fluorinated mono- and bis-imidazolidineiminothiones with antitumor, antiviral, antibacterial, and antifungal activities
  作者：Marwa A.M.Sh. El-Sharief、Ziad Moussa、Ahmed M.Sh. El-Sharief

  DOI：10.1016/j.jfluchem.2011.06.015

  日期：2011.9

  Aspergillus niger, and Aspergillus flavus). Whereas compound 6a exhibited the highest antibacterial activity against Gram positive and Gram negative bacteria, 13b displayed the strongest antifungal activity against all fungal strains, reaching as high as 30 mm. Finally, 15a,b,d were subjected to in vitro testing of antiviral activity against hepatitis A virus (HAV), human herpes simplex virus 1 (HSV1), and Coxsackie

  一系列38种新型咪唑烷亚氨基硫酮（6a – g，10a – h，13a，b，15a – d和16a），5-硫代氧杂咪唑烷-2,4-二酮（7a – d，11a – e，14a，b，和16B），和双- imidazolidineiminothiones（17 - 20），在各种氟化芳族取代基ñ - （1）和ñ-（3）的制备产率为75-85％。由氟化的N-芳基氰基硫代甲酰苯胺和取代的芳族异氰酸酯，以及氟化的芳族异氰酸酯与氟化的和非氟化的芳族N-芳基氰基硫代甲酰苯胺反应，合成咪唑烷亚氨基硫酮。所选产物的随后水解产生了相应的5-硫代氧杂咪唑烷-2，4-二酮。初步筛选了几种针对Ehrlich腹水癌细胞（EAC）的化合物，结果表明6f和16a的活性最高（分别为90％和80％抑制）。进一步评估针对其他肿瘤细胞系的细胞毒性，得出IC 50值为0.67至3.83μg/ mL，其中化合物15a和16a对所有细胞
• Polyisocyanurate foam prepared from an alkoxylated aromatic amine-aromatic polyester polyol blend
  申请人：THE CELOTEX CORPORATION

  公开号：EP0137489A2

  公开（公告）日：1985-04-17

  Polyisocyanurate foams are prepared by reacting together an organic polyisocyanate, a blowing agent, a trimerization catalyst, and a minor amount of a polyol blend comprising (a) about 5 percent to about 95 percent by weight of said blend of an alkylene oxide adduct of an aromatic amine of the formula wherein Z is a divalent aromatic radical, x, x', y, and y' each independently have an average value from about 1 to about 5, and each R is independently selected from the group consisting of hydrogen, alkyl or aryl, provided that the adduct is capped with ethylene oxide units, and (b) about 5 percent to about 95 percent by weight of said blend of an aromatic polyester polyol having a molecular weight of from about 150 to about 5,000. Laminates of such foams exhibit a high degree of fire resistance, low foam friability, high compressive strength, and excellent facer adhesion.

  将有机多异氰酸酯、发泡剂、三聚催化剂和少量多元醇混合物反应制备聚异氰脲酸酯泡沫塑料，多元醇混合物包括 (a) 所述混合物中约 5%至约 95%（按重量计）的环氧亚烷基加成芳香胺，其式为 其中 Z 是二价芳香基，x、x'、y 和 y'各自独立地具有从约 1 到约 5 的平均值，每个 R 独立地选自氢、烷基或芳基组成的组，条件是加合物用环氧乙烷单元封端，以及 (b) 大约 5%至 95%（按重量计）的芳香族聚酯多元醇混合物，其分子量约为 150 至 5000。这种泡沫的层压板具有高耐火性、低泡沫易碎性、高抗压强度和优异的面层粘合性。
• Plastic lenses having high-refractive index and process for the preparation thereof
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0329388A2

  公开（公告）日：1989-08-23

  The present invention relates to a process for preparing plastic lenses having a high-refractive index comprising forming a mixture containing one or more of polyisocyanate compounds; one or more active hydrogen compounds selected from the group consisting of a polyol compound having no sulfur atom, a polyol compound having at least one sulfur atom, and a polythiol compound having at least one sulfur atom in addition to the sulfur atom contained in mercapto group and at least one internal releasing agent and then casting and polymerizing the mixture.

  本发明涉及一种制备具有高折射率的塑料镜片的工艺，该工艺包括形成一种混合物，该混合物含有一种或多种多异氰酸酯化合物；一种或多种活性氢化合物，该活性氢化合物选自以下组别：不含硫原子的多元醇化合物、至少含一个硫原子的多元醇化合物、除巯基所含的硫原子外至少含一个硫原子的聚硫醇化合物；以及至少一种内部释放剂，然后浇铸和聚合该混合物。
• INSULATED WIRE
  申请人：THE FURUKAWA ELECTRIC CO., LTD.

  公开号：EP0977209A1

  公开（公告）日：2000-02-02

  There is disclosed an insulated wire, which comprises at least one insulating layer toned by applying and baking, directly or via another insulating layer on a conductor, a resin composition containing at least one selected from the group consisting of a polyamidimide resin and a polyimide resin, each having, in the molecular structure of the resin, a structure represented by formula (I), and/or a resin composition containing at least one selected from the group consisting of a polyamidimide resin and a polyimide resin, each having, in the molecular structure of the resin, a structure represented by formula (II), and said insulated wire has 0.2% yield stress of not more than 110 Mpa. This insulated wire, even if its insulation coating is made thinner, is excellent in resistance to scratches, and it is able to prevent the coating from breakage at the time of coil working, especially of the insertion of a coil into a stator slot, under rigorous conditions. In the formulae, R1, R2, R3, and R4, each are a hydrogen atom, an alkyl group, a hydroxyl group, a halogen atom, or an alkoxy group.

  本发明公开了一种绝缘电线，该电线包括至少一个绝缘层，该绝缘层是通过在导体上直接或通过另一个绝缘层涂敷和烘烤而调色的，该绝缘层是一种树脂组合物，该树脂组合物含有至少一种选自由聚酰胺酰亚胺树脂和聚酰亚胺树脂组成的组中的一种，每种树脂的分子结构中都具有式（I）所代表的结构，和/或一种树脂组合物，该树脂组合物含有至少一种选自由聚酰胺酰亚胺树脂和聚酰亚胺树脂组成的组中的一种，每种树脂的分子结构中都具有式（I）所代表的结构、或含有至少一种选自聚酰胺酰亚胺树脂和聚酰亚胺树脂组成的组的树脂组合物，每种树脂的分子结构均具有式 (II) 所表示的结构，且所述绝缘线具有 0.2% 的屈服应力不超过 110 兆帕。这种绝缘导线即使绝缘层变薄，也具有极佳的抗划伤能力，在线圈工作时，特别是在将线圈插入定子槽中的严格条件下，能够防止绝缘层破损。 式中，R1、R2、R3 和 R4 各为氢原子、烷基、羟基、卤素原子或烷氧基。
• RESIN COMPOSITION FOR SLIDE MEMBER AND ROLLER BEARING
  申请人：NTN Corporation

  公开号：EP2157135A1

  公开（公告）日：2010-02-24

  A resin composition for a sliding member is difficult to peel and whose component is difficult to elute when the resin composition is formed as a film on a surface of a mechanical part, even though the resin composition is used in environment where the slidingmember contacts lubricating oil containing a sulfur-based additive or in atmosphere containing a sulfur-based compound. A resin composition for a sliding member to be used for a mechanical part having a surface thereof formed of said sliding member. The resin composition contains polyamide-imide resin having an elongation percentage of 60% to 120%, fullerene, and at least one disulfide selected from among molybdenum disulfide and tungsten disulfide. 0.1 to 10 vol% of the fullerene and 0.5 to 20 vol% of the disulfide are contained in an entirety of the resin composition.

  一种用于滑动部件的树脂组合物，当该树脂组合物在机械部件表面形成薄膜时，即使该树脂组合物在滑动部件接触含有硫基添加剂的润滑油的环境中或在含有硫基化合物的大气中使用，也很难剥离，其成分也很难洗脱。一种用于机械零件滑动部件的树脂组合物，其表面由所述滑动部件形成。该树脂组合物含有伸长率为 60% 至 120% 的聚酰胺-酰亚胺树脂、富勒烯以及至少一种选自二硫化钼和二硫化钨的二硫化物。在整个树脂组合物中，富勒烯的含量为 0.1 至 10 Vol%，二硫化物的含量为 0.5 至 20 Vol%。