3',4'-二氯苯乙酮缩氨基脲 | 22107-28-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3',4'-二氯苯乙酮缩氨基脲
• 英文名称: 1-(3,4-dichloro-phenyl)-ethanone semicarbazone
• 英文别名: 1-(3,4-Dichlor-phenyl)-aethanon-semicarbazon；Acetophenone,4'-dichloro-, semicarbazone；[(E)-1-(3,4-dichlorophenyl)ethylideneamino]urea
• CAS: 22107-28-4
• 化学式: C₉H₉Cl₂N₃O
• 分子量: 246.096
• InChiKey: RNPCDQNIIZVNNZ-WLRTZDKTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  67.5
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2928000090

反应信息

• 作为产物：
  描述：

  邻二氯苯 在 三氯化铝 作用下， 生成 3',4'-二氯苯乙酮缩氨基脲
  参考文献：
  名称：

  Kshatriya; Shodhan; Nargund, Journal of the Indian Chemical Society, 1947, vol. 24, p. 373

  摘要：

  DOI：

文献信息

• Synthesis and Structure−Activity Relationship Study of Potent Trypanocidal Thio Semicarbazone Inhibitors of the Trypanosomal Cysteine Protease Cruzain
  作者：Xiaohui Du、Chun Guo、Elizabeth Hansell、Patricia S. Doyle、Conor R. Caffrey、Tod P. Holler、James H. McKerrow、Fred E. Cohen

  DOI：10.1021/jm010459j

  日期：2002.6.1

  American trypanosomiasis, or Chagas' disease, is the leading cause of heart disease in Latin America. Currently there is an urgent need to develop antitrypanosomal therapy due to the toxicity of existing agents and emerging drug resistance. A novel series of potent thio semicarbazone small-molecule inhibitors of the Trypanosoma cruzi cysteine protease cruzain have been identified. Some of these inhibitors have been shown to be trypanocidal. We initially discovered that X-bromopropiophenone thio semicarbazone (1i) inhibited cruzain and could cure mammalian cell cultures infected with T cruzi. 3'-Bromopropiophenone thio semicarbazone showed no toxicity for mammalian cells at concentrations that were trypanocidal. Following this lead, more than 100 compounds were designed and synthesized. A specific structure-activity relationship (SAR) was established, and many potent analogues with IC50 values in the low nanomolar range were identified. Eight additional analogues were trypanocidal in a cell culture assay, and this indicates that aryl thio semicarbazone is a productive scaffold for killing the parasites. Kinetic studies show that these are time-dependent inhibitors. Molecular modeling studies of the enzyme-inhibitor complex have led to a proposed mechanism of interaction as well as insight into the SAR of the thio semicarbazone series. The nonpeptide nature of this series, small size, and extremely low cost of production suggest this is a promising direction for the development of new antitrypanosome chemotherapy.
• Some aryl semicarbazones possessing anticonvulsant activitie
  作者：JR Dimmock、KK Sidhu、SD Tumber、SK Basran、M Chen、JW Quail、J Yang、I Rozas、DF Weaver

  DOI：10.1016/0223-5234(96)88237-7

  日期：——

  A number of aryl semicarbazones displayed anticonvulsant activity in the maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) screens when administered intraperitoneally to mice. When given by the oral route to rats, protection was afforded in the MES but not scPTZ tests. Correlations were noted between the sigma and sigma* values of the aryl substituents, the interplanar angles made by the aryl rings with the adjacent carbimino groups and the shapes of certain semicarbazones determined by X-ray crystallography, and the activities in the rat oral MES screen. Molecular modeling studies revealed a number of statistically significant descriptors which contributed to anticonvulsant activity.
• Kshatriya; Shodhan; Nargund, Journal of the Indian Chemical Society, 1947, vol. 24, p. 373
  作者：Kshatriya、Shodhan、Nargund

  DOI：——

  日期：——