3',5'-环脱氧腺苷酸 | 1157-33-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 中文名称: 3',5'-环脱氧腺苷酸
• 中文别名: 腺苷-2'-脱氧-3',5'-(磷酸氢)；2'-脱氧环磷酸腺苷
• 英文名称: Deoxy cyclic AMP
• 英文别名: 3',5'-cyclic monophosphate of 2'-deoxyadenosine；Deoxyadenosine cyclic 3',5'-hydrogen phosphate；2'-deoxyadenosine 3',5'-cyclic monophosphate；2'-deoxy cyclic adenosine 5'-monophosphate；2'-deoxy-cAMP；Desoxy AMPc；3',5'-Cyclic dAMP；9-[(4aR,6R,7aS)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]purin-6-amine
• CAS: 1157-33-1
• 化学式: C₁₀H₁₂N₅O₅P
• 分子量: 313.21
• InChiKey: MKMZAENVDZADSW-RRKCRQDMSA-N

物化性质

• 沸点：
  628.9±65.0 °C(Predicted)
• 密度：
  2.30±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  135
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  3',5'-环脱氧腺苷酸 在 盐酸 作用下， 生成 腺嘌呤
  参考文献：
  名称：

  Oivanen, Mikko; Rajamaeki, Markku; Varila, Jaana, Journal of the Chemical Society. Perkin transactions II, 1994, # 2, p. 309 - 314

  摘要：

  DOI：

文献信息

• ANTI-IRRITANT COMPOSITIONS CONTAINING A CYCLIC NUCLEOTIDE
  申请人：——

  公开号：US20020090384A1

  公开（公告）日：2002-07-11

  The present invention relates to cosmetic or pharmaceutical topical compositions containing at least one cyclic nucleotide having its 2′ hydroxyl group replaced by a hydrogen atom for inhibiting phosphodiesterase activity. The phosphodiesterase inhibitor is in combination with a magnesium buffer and a cosmetically or pharmaceutically acceptable carrier. The invention also includes methods for treating or preventing inflammation or irritation such as is common in the skin disease, atopic dermatitis, which is known to be related to the uncontrolled activity of phosphodiesterase.

  本发明涉及化妆品或药物外用组合物，其中至少含有一种环状核苷酸，其 2′羟基被氢原子取代，用于抑制磷酸二酯酶活性。磷酸二酯酶抑制剂与镁缓冲剂和化妆品或药学上可接受的载体结合使用。本发明还包括治疗或预防炎症或刺激的方法，如皮肤病特应性皮炎中常见的炎症或刺激，众所周知，特应性皮炎与磷酸二酯酶不受控制的活性有关。
• Li, Xinmin; Zhu, Bing; Zhao, Daqing, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996, vol. 35, # 11, p. 1144 - 1147
  作者：Li, Xinmin、Zhu, Bing、Zhao, Daqing、Ni, Jiazuan

  DOI：——

  日期：——
• ANTI-IRRITANT COMPOSITIONS CONTAINING A CYCLIC 2'-DEOXY-NUCLEOTIDE
  申请人：E-L Management Corp.

  公开号：EP1096938A1

  公开（公告）日：2001-05-09
• REAL-TIME SEQUENCING METHODS AND SYSTEMS
  申请人：Pacific Biosciences of California, Inc.

  公开号：EP2425023A2

  公开（公告）日：2012-03-07
• Real-Time Sequencing Methods and Systems
  申请人：Pacific Biosciences of California, Inc.

  公开号：US20140017680A1

  公开（公告）日：2014-01-16

  The present invention is generally directed to compositions, methods, and systems for performing single-molecule, real-time analysis of a variety of different biological reactions. The ability to analyze such reactions provides an opportunity to study those reactions as well as to potentially identify factors and/or approaches for impacting such reactions, e.g., to either enhance or inhibit such reactions. In certain preferred embodiments, RNA templates are used in single-molecule real-time sequencing reactions.