3,5-dichloro-N-phenylbenzamide | 5942-16-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,5-dichloro-N-phenylbenzamide
• CAS: 5942-16-5
• 化学式: C₁₃H₉Cl₂NO
• mdl: MFCD07261332
• 分子量: 266.127
• InChiKey: YNZIDEFPHIVLJR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-amino-3,5-dichloro-benzophenone 在 氢氧化钾 、 乙醚 、 五氯化磷 、 盐酸羟胺 作用下， 生成 3,5-dichloro-N-phenylbenzamide
  参考文献：
  名称：

  Waters, Journal of the Chemical Society, 1929, p. 2108

  摘要：

  DOI：

文献信息

• Fe-mediated synthesis of <i>N</i>-aryl amides from nitroarenes and acyl chlorides
  作者：Yundong Wu、Lei Guo、Yuxuan Liu、Jiannan Xiang、Jun Jiang

  DOI：10.1039/d0ra10868e

  日期：——

  are prevalent in nature and valuable functional compounds in agrochemical, pharmaceutical, and materials industries. In this work, we developed a selective and mild method for the synthesis of N-aryl amides. Starting from commercially available nitroarenes and acyl halides, N-aryl amides with good yields can be obtained in water. Especially in the process of transformation, Fe dust is the only reductant

  酰胺在自然界中普遍存在，在农业化学、制药和材料工业中是有价值的功能化合物。在这项工作中，我们开发了一种选择性和温和的方法来合成N-芳基酰胺。从市售的硝基芳烃和酰卤开始，可以在水中以良好的收率获得N-芳基酰胺。特别是在转化过程中，铁粉是唯一的还原剂和添加剂，反应很容易大规模进行。
• Cooperativity of H-bonding and anion–π interaction in the binding of anions with neutral π-acceptors
  作者：Michael Giese、Markus Albrecht、Tim Krappitz、Marius Peters、Verena Gossen、Gerhard Raabe、Arto Valkonen、Kari Rissanen

  DOI：10.1039/c2cc34748b

  日期：——

  A rare anion–π complex between bromide and a neutral receptor is reported and related receptor systems are studied with a series of anions. The interaction is observed in the solid state and in solution, and further evidence for it is obtained by a computational study.

  报道了一种罕见的阴离子-π复合物，涉及溴离子与中性受体的结合，并研究了相关受体系统与一系列阴离子的相互作用。这种相互作用在固态和溶液中都有观察到，并通过计算研究获得了进一步的证据。
• Copper and N-Heterocyclic Carbene-Catalyzed Oxidative Amidation of Aldehydes with Amines
  作者：Anudeep Kumar Narula、Ashmita Singh

  DOI：10.1055/a-1343-5203

  日期：2021.4

  one-pot two-step oxidative process has been developed for the tert-butyl hydroperoxide mediated transformation of aldehydes and amines into amides catalyzed by copper(I) iodide and an N-heterocyclic carbene. The process is additive-free and does not require the amine to be transformed into its hydrochloride salts. The method is simple and practicable, has a broad substrate scope, and uses economical, feasible

  已经开发了一种一锅两步氧化方法，用于叔丁基氢过氧化物介导的碘化铜（I）和N-杂环卡宾催化的醛和胺向酰胺的转化。该方法是无添加剂的，不需要将胺转化为其盐酸盐。该方法简单实用，底物范围广，使用经济，可行，试剂丰富。
• Solid-Supported Cyclohexane-1,3-dione (CHD):  A “Capture and Release” Reagent for the Synthesis of Amides and Novel Scavenger Resin
  作者：Cara E. Humphrey、Morag A. M. Easson、Jason P. Tierney、Nicholas J. Turner

  DOI：10.1021/ol027503p

  日期：2003.3.1

  [reaction: see text] A three-step synthesis of cyclohexane-1,3-dione (CHD) resin 6 on polystyrene resin is described. Resin 6 was used to prepare an amide library of high purity by microwave-assisted serial "capture and release" and can be recycled for this purpose. High-loading CHD resin 10 was also shown to scavenge allyl cations in solution.

  [反应：参见正文]描述了在聚苯乙烯树脂上的三步合成环己烷-1,3-二酮（CHD）树脂6。树脂6用于通过微波辅助系列“捕获和释放”制备高纯度的酰胺库，并且可以为此目的进行回收。高负荷的CHD树脂10也显示出清除溶液中的烯丙基阳离子。
• US7541459B2
  申请人：——

  公开号：US7541459B2

  公开（公告）日：2009-06-02