(5-fluoro-2-hydroxybenzyl)(triphenyl)phosphonium bromide | 934738-25-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (5-fluoro-2-hydroxybenzyl)(triphenyl)phosphonium bromide
• 英文别名: (5-Fluoro-2-hydroxybenzyl)(triphenyl)phosphonium bromide；(5-fluoro-2-hydroxyphenyl)methyl-triphenylphosphanium;bromide
• CAS: 934738-25-7
• 化学式: Br*C₂₅H₂₁FOP
• 分子量: 467.317
• InChiKey: VVSVGJFWTCIUMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.03
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-二甲氨基苯甲酰氯 、 (5-fluoro-2-hydroxybenzyl)(triphenyl)phosphonium bromide 在 三乙胺 作用下， 以 甲苯 为溶剂， 生成 4-(5-fluoro-1-benzofuran-2-yl)-N,N-dimethylaniline
  参考文献：
  名称：

  Fluorinated Benzofuran Derivatives for PET Imaging of β-Amyloid Plaques in Alzheimer's Disease Brains

  摘要：

  A series of fluorinated benzofuran derivatives as potential tracers for positron emission tomography (PET) targeting beta-amyloid plaques in the brains of patients with Alzheimer's disease (AD) were synthesized and evaluated. The derivatives were produced using an intramolecular Wittig reaction. In experiments in vitro, all displayed high affinity for A beta(1-42) aggregates with K-i values in the nanomolar range. Radiofluorinated 17,[F-18]17, in particular labeled beta-amyloid plaques in sections of Tg2576 mouse brain and displayed high uptake (5.66% ID/g) at 10 min postinjection, sufficient for PET imaging. In addition, in vivo beta-amyloid plaque labeling can be clearly demonstrated with [F-18]17 in Tg2576 mice. In conclusion, [F-18]17 may be useful for detecting beta-amyloid plaques in patients with AD.

  DOI：

  10.1021/ml100082x
• 作为产物：
  描述：

  三苯基膦氢溴酸盐 、 5-fluoro-2-hydroxy-benzyl alcohol 以 乙腈 为溶剂， 反应 3.0h， 以100%的产率得到(5-fluoro-2-hydroxybenzyl)(triphenyl)phosphonium bromide
  参考文献：
  名称：

  LACTAM-SUBSTITUTED DICARBOXYLIC ACIDS AND USE THEREOF

  摘要：

  本申请涉及新型内酰胺取代的二羧酸衍生物，其制备方法，其用于治疗和/或预防疾病的用途，以及其用于生产治疗和/或预防疾病的药物的用途，特别是用于治疗和/或预防心血管疾病。

  公开号：

  US20100197680A1

文献信息

• Dicarboxylic Acid Derivatives and their Use
  申请人：Bartel Stephan

  公开号：US20100029772A1

  公开（公告）日：2010-02-04

  The present application relates to novel dicarboxylic acid derivatives, process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.

  本申请涉及新颖的二羧酸衍生物，其制备方法，它们用于治疗和/或预防疾病的用途，以及它们用于生产治疗和/或预防疾病的药物的用途，特别是用于治疗和/或预防心血管疾病的用途。
• SUBSTITUTED DIBENZOIC ACID DERIVATIVES AND USE THEREOF
  申请人：Hahn Michael

  公开号：US20100168240A1

  公开（公告）日：2010-07-01

  The invention relates to novel substituted dibenzoic acid derivatives of formula (I), wherein A represents a group of formula (II) or (III), to methods for producing the same, and to their use in the treatment and/or prophylaxis of diseases. The invention also relates to the use of said substances in the production of drugs for the treatment and/or prophylaxis of diseases, especially in the treatment and/or prevention of cardiovascular diseases.

  该发明涉及公式（I）的新颖取代二苯甲酸衍生物，其中A代表公式（II）或（III）的一个基团，以及其制备方法，以及它们在治疗和/或预防疾病中的用途。该发明还涉及上述物质在制备用于治疗和/或预防疾病的药物中的应用，特别是在治疗和/或预防心血管疾病方面的应用。
• Substituted dibenzoic acid derivatives and use thereof
  申请人：Bayer Schering Pharma Aktiengesellschaft

  公开号：US07985876B2

  公开（公告）日：2011-07-26

  The invention relates to novel substituted dibenzoic acid derivatives of formula (I), wherein A represents a group of formula (II) or (III), to methods for producing the same, and to their use in the treatment and/or prophylaxis of diseases. The invention also relates to the use of said substances in the production of drugs for the treatment and/or prophylaxis of diseases, especially in the treatment and/or prevention of cardiovascular diseases.

  本发明涉及一种新型的取代二苯甲酸衍生物，其化学式为(I)，其中A代表化学式(II)或(III)的基团，以及制备它们的方法，以及它们在治疗和/或预防疾病中的应用。本发明还涉及上述物质在制备用于治疗和/或预防疾病的药物中的应用，特别是在治疗和/或预防心血管疾病方面的应用。
• Lactam-substituted dicarboxylic acids and use thereof
  申请人：Bayer Intellectual Property GmbH

  公开号：US08217063B2

  公开（公告）日：2012-07-10

  The present application relates to novel lactam-substituted dicarboxylic acid derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.

  本申请涉及新颖的内酰胺取代的二羧酸衍生物，其制备方法，其用于治疗和/或预防疾病以及用于制备治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管疾病。
• Dicarboxylic acid derivatives and their use
  申请人：Bartel Stephan

  公开号：US08609727B2

  公开（公告）日：2013-12-17

  The present application relates to novel dicarboxylic acid derivatives, process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.

  本申请涉及新型二羧酸衍生物，其制备方法，其用于治疗和/或预防疾病的用途，以及其用于生产治疗和/或预防疾病的药物的用途，特别是用于治疗和/或预防心血管疾病的用途。