3,3'-[(2-甲基丙基)磷基]二丙烷-1-醇 | 147768-39-6

• 分子结构分类: 有机化合物 - 有机磷化合物 - 有机膦及其衍生物
• 中文名称: 3,3'-[(2-甲基丙基)磷基]二丙烷-1-醇
• 英文名称: 1-Propanol, 3,3'-[(2-methylpropyl)phosphinylidene]bis-
• 英文别名: 3-[3-hydroxypropyl(2-methylpropyl)phosphoryl]propan-1-ol
• CAS: 147768-39-6
• 化学式: C₁₀H₂₃O₃P
• 分子量: 222.26
• InChiKey: RBOSLVRUYBQPOX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• BTK INHIBITORS
  申请人：KIM RONALD M.

  公开号：US20140206681A1

  公开（公告）日：2014-07-24

  The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.

  本发明提供了根据式I提供的Bruton's酪氨酸激酶（Btk）抑制剂化合物，或其药学上可接受的盐，或包含这些化合物的药物组合物，并且用于治疗的使用。具体地，本发明涉及在治疗Btk介导的疾病中使用Btk抑制剂化合物。
• [EN] BTK INHIBITORS<br/>[FR] INHIBITEURS DE BTK
  申请人：MERCK SHARP & DOHME

  公开号：WO2014114185A1

  公开（公告）日：2014-07-31

  The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.

  本发明提供了根据式I或其药学上可接受的盐制备的Bruton's酪氨酸激酶（Btk）抑制剂化合物，或包含这些化合物的药物组合物，并且提供了这些化合物在治疗中的应用。具体而言，本发明涉及在治疗Btk介导的疾病中使用Btk抑制剂化合物。
• MELAMINE PHENYLPHOSPHINATE FLAME RETARDANT COMPOSITIONS
  申请人：Fuchs Sabine

  公开号：US20110288206A1

  公开（公告）日：2011-11-24

  The present invention relates to flame retardant polymer compositions which comprise melamine phenylphosphinates and mixtures with dihydro-oxa-phosphaphenanthrene derivatives. The compositions are especially useful for the manufacture of flame retardant compounds based on polyfunctional epoxides or polycondensates like polyesters, polyamides and polycarbonates.

  本发明涉及一种阻燃聚合物组合物，其包括三聚氰胺苯基膦酸盐和二氢氧化磷酞类衍生物的混合物。该组合物特别适用于制造基于多官能团环氧树脂或聚酯、聚酰胺和聚碳酸酯的阻燃化合物。
• FLAME RETARDANT COMBINATIONS OF HYDROXYALKYL PHOSPHINE OXIDES WITH 1,3,5-TRIAZINES AND EPOXIDES
  申请人：Fuchs Sabine

  公开号：US20100210763A1

  公开（公告）日：2010-08-19

  The present invention relates to flame retardant polymer compositions which comprise combinations of hydroxyalkyl phosphine oxides with 1,3,5-triazine compounds and polyfunctional epoxide compounds. The compositions are in the form of epoxy laminates which are useful for the manufacture of prepregs, laminates for the preparation of printed circuit boards and printed wiring boards.

  本发明涉及阻燃聚合物组合物，其包括羟基烷基膦氧化物与1,3,5-三嗪化合物和多官能团环氧化合物的组合。这些组合物以环氧树脂层压板的形式存在，可用于制造预浸料、制备印刷电路板和印刷布线板的层压板。
• Fire retardant epoxy resin compositions
  申请人：CYTEC TECHNOLOGY CORP.

  公开号：EP0490065A2

  公开（公告）日：1992-06-17

  Thermosetting epoxy resin compositions having improved flame retardancy having combined therewith an effective amount of a dihydroxymethyl phosphine oxide having the general formula wherein R represents an alkyl group having from 1 to about 8 carbon atoms or -R'OH where R' represents an alkylene group having from 2 to about 8 carbon atoms, are disclosed.

  具有更佳阻燃性的热固性环氧树脂组合物，其中含有有效量的二羟甲基氧化膦，其通式为 其中 R 代表具有 1 至 8 个碳原子的烷基或 -R'OH 其中 R' 代表具有 2 至 8 个碳原子的亚烷基。