3-chloro-10H-phenoxazine | 59701-59-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 3-chloro-10H-phenoxazine
• 英文别名: 3-Chlor-phenoxazin；2-Chlorphenoxazin；3-chlorophenoxazine
• CAS: 59701-59-6
• 化学式: C₁₂H₈ClNO
• 分子量: 217.655
• InChiKey: IODUOIUYROGXDX-UHFFFAOYSA-N

物化性质

• 沸点：
  348.4±41.0 °C(Predicted)
• 密度：
  1.318±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-chloro-10H-phenoxazine 、 2-溴-9,9'-螺二芴 在 copper(l) iodide 、 1,10-菲罗啉 、 18-冠醚-6 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 19.0h， 以64%的产率得到
  参考文献：
  名称：

  含氮化合物、电子元件及电子装置

  摘要：

  本公开提供一种含氮化合物、电子元件及电子装置，属于有机材料技术领域。该含氮化合物如式I所示，其可降低器件的工作电压、提高器件效率，延长器件寿命。

  公开号：

  CN110903260B

文献信息

• Phenothiazines, phenoxazines and acridan bis-pyrrolinyl derivatives
  申请人：Mead Johnson & Company

  公开号：US03946004A1

  公开（公告）日：1976-03-23

  Novel amidine compounds selected from the group consisting of bis-pyrrolinyl derivatives of phenothiazines, phenoxazines and acridans are obtained by reacting a phenothiazine, phenoxazine or acridan with a pyrrolidinone in the presence of phosphorus oxychloride. The phenothiazine, phenoxazine, or acridan can also be alkylated with 2-chloro-1-(1-pyrrolin-2-yl)-2-pyrroline to provide compounds of the invention. Typical examples of bis-pyrrolinyl derivatives are 2-methoxy-10-[5-methyl-1-(5-methyl-1-pyrrolin-2-yl)-2-pyrrolin-2-yl]-pheno thiazine, 10-[1-(1-pyrrolin-2-yl)-2-pyrrolin-2-yl]phenoxazine, and 9,9-dimethyl-10-[5-methyl-1-(5-methyl-1-pyrrolin-2-yl)-2-pyrrolin-2-yl]acr idan. The amidine compounds are useful as diuretics, smooth muscle relaxants and antithrombogenic agents.

  从苯并噻嗪，苯并噁嗪和乙酰基蒽中选择的双吡咯烷衍生物中选出新型的氨基咪啉化合物。在磷酸氧氯化物的存在下，将苯并噻嗪，苯并噁嗪或乙酰基蒽与吡咯酮反应即可得到该化合物。苯并噻嗪，苯并噁嗪或乙酰基蒽也可以与2-氯-1-(1-吡咯烷-2-基)-2-吡咯烷烷基化，以提供本发明的化合物。双吡咯烷衍生物的典型例子是2-甲氧基-10-[5-甲基-1-(5-甲基-1-吡咯烷-2-基)-2-吡咯烷-2-基]-苯并噻嗪，10-[1-(1-吡咯烷-2-基)-2-吡咯烷-2-基]苯并噁嗪和9,9-二甲基-10-[5-甲基-1-(5-甲基-1-吡咯烷-2-基)-2-吡咯烷-2-基]乙酰基蒽。该氨基咪啉化合物可用作利尿剂，平滑肌松弛剂和抗血栓形成剂。
• 10-(Bis-pyrrolinyl)acridans
  申请人：Mead Johnson & Company

  公开号：US04077959A1

  公开（公告）日：1978-03-07

  Novel amidine compounds selected from the group consisting of bis-pyrrolinyl derivatives of phenothiazines, phenoxazines and acridans are obtained by reacting a phenothiazine, phenoxazine or acridan with a pyrrolidinone in the presence of phosphorus oxychloride. The phenothiazine, phenoxazine, or acridan can also be alkylated with 2-chloro-1-(1-pyrrolin-2-yl)-2-pyrroline to provide compounds of the invention. Typical examples of bis-pyrrolinyl derivatives are 2-methoxy-10-[5-methyl-1-(5-methyl-1-pyrrolin-2-yl)-2-pyrrolin-2yl]phenoth iazine, 10-[1-(1-pyrrolin-2-yl)-2-pyrrolin-2-yl]phenoxazine, and 9,9-dimethyl-10-[5-methyl-1-(5-methyl-1-pyrrolin-2-yl)-2-pyrrolin-2-yl]acr idan. The amidine compounds are useful as diuretics, smooth muscle relaxants and antithrombogenic agents.

  本发明提供了从苯并噻嗪、苯并噁嗪和乙酰苯并噻吩的双吡咯烷衍生物中选择的新型肼类化合物，其通过在磷酸氧氯化物存在下将苯并噻嗪、苯并噁嗪或乙酰苯并噻吩与吡咯烷酮反应而得到。苯并噻嗪、苯并噁嗪或乙酰苯并噻吩也可以与2-氯-1-(1-吡咯烷-2-基)-2-吡咯烯烃基化，以提供本发明的化合物。典型的双吡咯烷衍生物的例子包括2-甲氧基-10-[5-甲基-1-(5-甲基-1-吡咯烷-2-基)-2-吡咯烯基]苯并噻嗪、10-[1-(1-吡咯烷-2-基)-2-吡咯烯基]苯并噁嗪和9,9-二甲基-10-[5-甲基-1-(5-甲基-1-吡咯烷-2-基)-2-吡咯烯基]乙酰苯并噻吩。这些肼类化合物可用作利尿剂、平滑肌松弛剂和抗血栓形成剂。
• 10-(Bis-pyrrolinyl) phenoxazines
  申请人：Mead Johnson & Company

  公开号：US04115571A1

  公开（公告）日：1978-09-19

  Novel amidine compounds selected from the group consisting of bis-pyrrolinyl derivatives of phenothiazines, phenoxazines and acridans are obtained by reacting a phenothiazine, phenoxazine or acridan with a pyrrolidinone in the presence of phosphorus oxychloride. The phenothiazine, phenoxazine, or acridan can also be alkylated with 2-chloro-1-(1-pyrrolin-2-yl)-2-pyrroline to provide compounds of the invention. Typical examples of bis-pyrrolinyl derivatives are 2-methoxy-10-[5-methyl-1-(5-methyl-1-pyrrolinyl-2-yl)-2-pyrrolin-2-yl]-phe nothiazine, 10-[1-(1-pyrrolin-2-yl)-2-pyrrolin-2-yl]phenoxazine, and 9,9-dimethyl-10-[5-methyl-1-(5-methyl-1-pyrrolin-2-yl)-2-pyrrolin-2-yl]acr idan. The amidine compounds are useful as diuretics, smooth muscle relaxants and antithrombogenic agents.

  从苯并噻吩、苯并噁嗪和乙脒并吖啶衍生物的双吡咯烷衍生物组中选择的新型酰胺化合物可通过在三氯化磷的存在下将苯并噻吩、苯并噁嗪或乙脒并吖啶与吡咯烷酮反应而得到。苯并噻吩、苯并噁嗪或乙脒并吖啶也可以与2-氯-1-(1-吡咯烷-2-基)-2-吡咯烯烃基化以提供本发明的化合物。双吡咯烷衍生物的典型例子包括2-甲氧基-10-[5-甲基-1-(5-甲基-1-吡咯烷-2-基)-2-吡咯烯-2-基]-苯并噻吩、10-[1-(1-吡咯烷-2-基)-2-吡咯烯-2-基]苯并噁嗪和9,9-二甲基-10-[5-甲基-1-(5-甲基-1-吡咯烷-2-基)-2-吡咯烯-2-基]乙脒并吖啶。这些酰胺化合物可用作利尿剂、平滑肌松弛剂和抗血栓形成剂。
• Heterocyclic constrained tricyclic sulfonamides as anti-cancer agents
  申请人：ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

  公开号：US10759790B2

  公开（公告）日：2020-09-01

  A genus of arylsulfonamide derivatives of heterocyclic constrained tricyclic compounds is disclosed. The compounds are of the following genus: The compounds induce FOXO1 transcription factor translocation to the nucleus by modulating PP2A and, as a consequence, exhibit anti-proliferative effects. They are useful in the treatment of a variety of disorders, including as a therapy in cancer treatment, or used in combination with other drugs to restore sensitivity to chemotherapy where resistance has developed.

  本发明公开了一种杂环受限三环化合物的芳基磺酰胺衍生物。这些化合物属 这些化合物通过调节 PP2A 诱导 FOXO1 转录因子转位到细胞核，因此具有抗增殖作用。它们可用于治疗多种疾病，包括癌症治疗，或与其他药物联合使用，以恢复对已产生抗药性的化疗的敏感性。
• Nitrogen-containing compound, electronic element, and electronic device
  申请人：SHAANXI LIGHTE OPTOELECTRONICS MATERIAL CO., LTD.

  公开号：US11524970B2

  公开（公告）日：2022-12-13

  Provided are a nitrogen-containing compound, an electronic element, and an electronic device, and relates to the technical field of organic materials. The nitrogen-containing compound is shown as formula I, and can reduce the working voltage of an electronic element, improve the efficiency of an OLED, and prolong the service life of an OLED.

  本发明提供了一种含氮化合物、一种电子元件和一种电子器件，涉及有机材料技术领域。该含氮化合物如式 I 所示，可降低电子元件的工作电压，提高 OLED 的效率，延长 OLED 的使用寿命。