2,5-Dimethyl-N-propylpyrrolidin | 72753-10-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 2,5-Dimethyl-N-propylpyrrolidin
• 英文别名: 2,5-dimethyl-1-propyl-pyrrolidine；2,5-Dimethyl-1-propyl-pyrrolidin；2,5-Dimethyl-1-propylpyrrolidine
• CAS: 72753-10-7
• 化学式: C₉H₁₉N
• 分子量: 141.257
• InChiKey: VOBSQCMROSKYFS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2,5-己二酮 以7%的产率得到
  参考文献：
  名称：

  KOZLOV N. S.; MOJSEENOK L. I.; KOZINTSEV S. I., XIM. GETEROTSIKL. SOEDIN., 1979, HO 11, 1483-1485

  摘要：

  DOI：

文献信息

• SPIROCYCLIC GPR40 MODULATORS
  申请人：Brown Sean P.

  公开号：US20110190330A1

  公开（公告）日：2011-08-04

  The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula IA, IB, I′A or I′B: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

  本发明提供了一些化合物，例如用于治疗受试者的代谢性疾病。这些化合物具有一般式IA、IB、I′A或I′B，其中变量的定义在此处提供。本发明还提供了包括这些化合物的组合物，以及使用这些化合物制备药物和治疗代谢性疾病（例如2型糖尿病）的方法。
• SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：US20150072959A1

  公开（公告）日：2015-03-12

  Substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.

  本文揭示了替代三唑类化合物及含有该化合物的药物组合物，用于抑制受体蛋白酪氨酸激酶Axl的活性。还揭示了使用该化合物治疗与Axl活性相关的疾病或病状的方法。
• Ochiai; Tsuda, Chemische Berichte, 1934, vol. 67, p. 1011,1013,1018
  作者：Ochiai、Tsuda

  DOI：——

  日期：——
• BENHAMOU M. C.; ETEMAD-MOGHADAM G.; SPEZIALE V.; LATTES A., SYNTHESIS, 1979, NO 11, 891-892
  作者：BENHAMOU M. C.、 ETEMAD-MOGHADAM G.、 SPEZIALE V.、 LATTES A.

  DOI：——

  日期：——
• System for the determination of selective absorbent molecules through predictive correlations
  申请人：Furman Kevin C.

  公开号：US20110202328A1

  公开（公告）日：2011-08-18

  A method for determining absorbent molecules that are effective for the property of acid gas removal from feedstreams comprising a) determining a set of known molecules that are effective for acid gas removal, b) defining descriptive parameters (descriptors) that correlate with the structure of molecules with known acid gas removal, c) assigning a value to each descriptor for each of the known molecules and developing a quantitative structure and property relationship (QSPR), and d) generating molecular structures that will be effective for acid gas removal from the structure and property relationship.