甲基3-O-苄基-D-甘油酸盐 | 209907-54-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 甲基3-O-苄基-D-甘油酸盐
• 中文别名: 3-O-苄基-D-甘油酸甲酯
• 英文名称: methyl (2R)-3-benzyloxy-2-hydroxypropanoate
• 英文别名: (R)-3-benzyloxy-2-hydroxy-propionic acid methyl ester；(R)-3-Benzyloxy-2-hydroxy-propionsaeure-methylester；(R)-Methyl 3-(benzyloxy)-2-hydroxypropanoate；methyl (2R)-2-hydroxy-3-phenylmethoxypropanoate
• CAS: 209907-54-0
• 化学式: C₁₁H₁₄O₄
• 分子量: 210.23
• InChiKey: ACBWWWIGOQIBMS-SNVBAGLBSA-N

物化性质

• 沸点：
  342.2±27.0 °C(Predicted)
• 密度：
  1.171±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于氯仿（少许）、DMSO（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  甲基3-O-苄基-D-甘油酸盐 在 吡啶 、 苯甲酰氯 作用下， 生成 (R)-2-hydroxy-3-hydroxyphosphinoyloxy-propionic acid
  参考文献：
  名称：

  The use of the Liverpool University neuroleptic side‐effect rating scale (LUNSERS) in clinical practice

  摘要：

  ABSTRACTForty‐four mental health clients completed the Liverpool University Neuroleptic Side‐Effect Rating Scale (LUNSERS)—a self‐rating scale to assess the prevalence and intensity of neuroleptic side‐effects. In the month prior to the study, 50% of the clients surveyed had experienced more than half of the side‐effects outlined on the 41‐item scale. A prevalence profile allowed us to rank the frequency of individual side‐effects across the sample. Some side‐effects such as ‘difficulty concentrating’, ‘difficulty remembering’, ‘tiredness’ and ‘restlessness’ were experienced by most of the clients in the study while ‘unusual skin marks’, ‘difficulty passing water’, ‘rashes’ were experienced by a few. A prevalence profile may be a useful guide in developing strategies for managing side‐effects more effectively in small groups of clients. In addition, the use of the LUNSERS in clinical practice would enable case managers to establish baseline measures for individual clients and evaluate changes in medication and other non‐medical strategies for reducing unwanted side‐effects. The identification and assessment of antipsychotic side‐effects is an important area for client and professional carer education.

  DOI：

  10.1046/j.1440-0979.2000.00181.x
• 作为产物：
  描述：

  O-苄基-D-丝氨酸 在 盐酸 、 硫酸 、 sodium nitrite 作用下， 以 甲醇 、 水 为溶剂， 反应 29.5h， 生成 甲基3-O-苄基-D-甘油酸盐
  参考文献：
  名称：

  [EN] HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT
  [FR] HYDROXYCOUMARINES ET ALCOXYCOUMARINES UTILES COMME MODULATEURS DE POLRMT

  摘要：

  The present invention provides novel hydroxy and alkoxy coumarin compounds that are inhibitors of mitochondrial RNA polymerase for treating various diseases such as cancer and others associated with metabolic disorders and mitochondrial dysfunction.

  公开号：

  WO2023034340A1

文献信息

• [EN] NEW CONTRAST AGENT FOR USE IN MAGNETIC RESONANCE IMAGING<br/>[FR] NOUVEL AGENT DE CONTRASTE DESTINÉ À ÊTRE UTILISÉ DANS L'IMAGERIE PAR RÉSONANCE MAGNÉTIQUE
  申请人：BAYER AG

  公开号：WO2022194777A1

  公开（公告）日：2022-09-22

  The present invention relates to a new class of compounds of general formula (I), the Gd3+chelate complexes thereof, to methods of preparing said compounds, and to the use of said compounds as MRI contrast agents. Formula (I)

  本发明涉及一类新的通式（I）化合物、其钆3+螯合物、制备上述化合物的方法以及上述化合物作为 MRI 造影剂的用途。通式 (I)
• Ballou, Biochemical Preparations, 1957, vol. 5, p. 66,67
  作者：Ballou

  DOI：——

  日期：——
• A New Synthesis of 2-Phosphoryl-D-glyceric Acid
  作者：Clinton E. Ballou、Hermann O. L. Fischer

  DOI：10.1021/ja01641a023

  日期：1954.6
• New efficient enantioselective synthesis of 2-oxopiperazines: a practical access to chiral 3-substituted 2-oxopiperazines
  作者：Claiton Leoneti Lencina、Alexandra Dassonville-Klimpt、Pascal Sonnet

  DOI：10.1016/j.tetasy.2008.06.030

  日期：2008.7

  The development of efficient and stereoselective methods to produce 1,4-disubstituted-2-oxopiperazine in enantiomerically pure form, from a readily available starting material is crucial. Herein, we report a reduction modification to our previously described synthesis of 1,4-disubstituted-2-oxopiperazine and also two original shortly accessed pathways. These new pathways can be routinely performed on a multigram scale and should rapidly find a place in the preparation of the 3-substituted-2-oxopiperazine diastereomers. Stereoselective alkylation of 1,4-disubstituted-2-oxopiperazine led to the corresponding (3S)-diastereomer or (3R)-diastereomer from the corresponding 2-oxopiperazine enantiomer with the chiral inductor substituted at the N-1 (1*) position, respectively, in good yield. (C) 2008 Elsevier Ltd. All rights reserved.
• The Effect of Cesium Fluoride-DMF in the Dibutylstannylene Acetal-Mediated Selective Monobenzylation of Methyl 2,3-D-Glycerate.
  作者：Joseph Arukwe、Thorarinn Stefansson、Halldor Snorrason、Wei Chen、Ása Guorún Kristjánsdóttir、Olle Matsson、Kurt V. Mikkelsen、Alexander Senning

  DOI：10.3891/acta.chem.scand.52-0819

  日期：——