(R)-(3-bromophenyl)((S)-oxiran-2-yl)methanol | 1075178-88-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-(3-bromophenyl)((S)-oxiran-2-yl)methanol
• 英文别名: (1R,2S)-(3-bromophenyl)-2,3-glycidol；(1S,2R)-1-(3-bromophenyl)glycidol；(R)-(3-bromophenyl)-[(2S)-oxiran-2-yl]methanol
• CAS: 1075178-88-9
• 化学式: C₉H₉BrO₂
• 分子量: 229.073
• InChiKey: KMDNYHBACVVPHW-DTWKUNHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  32.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (S)-1-(3-bromophenyl)prop-2-en-1-ol 在 styrene monooxygenase 作用下， 以 aq. phosphate buffer 为溶剂， 反应 36.0h， 以99%的产率得到
  参考文献：
  名称：

  Synthesis of enantiopure glycidol derivatives via a one-pot two-step enzymatic cascade

  摘要：

  描述了一种使用特异性酮还原酶和苯乙烯单加氧酶进行酶级级联反应以合成对映纯的环氧乙烷衍生物的方法。

  DOI：

  10.1039/c4ob02186j

文献信息

• AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS
  申请人：Acucela, Inc.

  公开号：US20160193181A1

  公开（公告）日：2016-07-07

  Provided are amine derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

  提供的是胺衍生物化合物、其药物组合物，以及使用所述化合物和组合物治疗眼科疾病和障碍的方法，例如年龄相关的黄斑变性和斯达格特病。
• Highly diastereo- and enantio-selective epoxidation of secondary allylic alcohols catalyzed by styrene monooxygenase
  作者：Hui Lin、Yan Liu、Zhong-Liu Wu

  DOI：10.1039/c0cc04360e

  日期：——

  Enantiomerically enriched glycidol derivatives with contiguous stereogenic centers were obtained in a highly diastereo- and enantio-selective epoxidation catalyzed with the styrene monooxygenase StyAB2.

  在以苯乙烯单加氧酶StyAB2作为催化剂的高度立体选择性和对映选择性环氧化反应中，获得了具有相邻立体中心的高对映体富集的缩水甘油衍生物。
• Amine Derivative Compounds for Treating Ophthalmic Diseases and Disorders
  申请人：Scott Ian L.

  公开号：US20090281149A1

  公开（公告）日：2009-11-12

  Provided are amine derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

  本发明涉及一种胺衍生物化合物，其制备的药物组合物以及使用该化合物和组合物治疗眼科疾病和障碍的方法，例如老年性黄斑变性和Stargardt病。
• STYRENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS
  申请人：Scott Ian Leslie

  公开号：US20120129860A1

  公开（公告）日：2012-05-24

  The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

  本发明通常涉及用于治疗神经退行性疾病和障碍的组合物和方法，特别是用于治疗眼科疾病和障碍。本文提供了包括但不限于苯乙烯衍生物化合物和含有这些化合物的组合物，这些化合物对于治疗和预防眼科疾病和障碍，包括年龄相关性黄斑退化（AMD）和Stargardt病都非常有用。
• Styrenyl Derivative Compounds for Treating Ophthalmic Diseases and Disorders
  申请人：Acucela Inc.

  公开号：US20150166494A1

  公开（公告）日：2015-06-18

  The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

  本发明涉及一般用于治疗神经退行性疾病和紊乱的组合物和方法，特别是用于治疗眼科疾病和紊乱。本文提供了包括但不限于苯乙烯衍生物化合物和含有这些化合物的组合物，这些化合物可用于治疗和预防眼科疾病和紊乱，包括老年性黄斑变性（AMD）和Stargardt病。