(S)-3-Adenin-9-yl-lactic acid | 70259-43-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: (S)-3-Adenin-9-yl-lactic acid
• 英文别名: 3-(6-amino-purin-9-yl)-2-hydroxy-propionic acid；(2S)-3-(6-aminopurin-9-yl)-2-hydroxy-propanoic acid；(2S)-3-(6-aminopurin-9-yl)-2-hydroxypropanoic acid
• CAS: 70259-43-7
• 化学式: C₈H₉N₅O₃
• 分子量: 223.191
• InChiKey: UHOFECKRSHSYNE-BYPYZUCNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  127
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  (L)-9-(α,β-1-methyl-5-ribofuranosyl)adenine 在 potassium permanganate 、 sodium periodate 、 Dowex 50 (H⁺) 作用下， 反应 25.0h， 生成 (S)-3-Adenin-9-yl-lactic acid
  参考文献：
  名称：

  合成光学活性烷基化腺嘌呤衍生物的新方法。

  摘要：

  提出了一种新的手性无环核苷和核苷酸类似物的合成方法，从d（-）-或l（+）-核糖开始。评估了合成化合物对痘病毒家族的抗病毒特性。

  DOI：

  10.1016/j.bmcl.2003.12.107

文献信息

• Prodrug derivatives of acids using alcohols with homotopic hydroxy groups and methods for their preparation and use
  申请人：deLong A. Mitchell

  公开号：US20070254920A1

  公开（公告）日：2007-11-01

  This invention relates to novel homotopic prodrugs and medicaments and methods for their preparation, testing and use. In one embodiment, the homotopic prodrug has the general formula wherein is a biologically-active moiety comprising a carboxylic acid functional group, and R b is a homotopically-symmetrical alcohol bonded to the biologically-active moiety through the carboxylic acid functional group to form an ester linkage, as well as optical isomers, enantiomers, pharmaceutically acceptable salts, biohydrolyzable amides, esters, and imides thereof and combinations thereof.

  这项发明涉及新型同位素前药、药物以及其制备、测试和使用方法。在一个实施例中，同位素前药具有一般公式 其中 是包含羧酸官能团的生物活性基团，而 R b 是通过羧酸官能团与生物活性基团形成酯键的同位对称醇，以及其光学异构体、对映异构体、药用可接受盐、生物水解酰胺、酯、亚酰胺及其组合物。
• Ophthamological drugs
  申请人：Toone J. Eric

  公开号：US20060135609A1

  公开（公告）日：2006-06-22

  The present invention relates generally to ophthamological drugs. More specifically, the inventon relates to a method of modifying (derivatizing) ophthamological drugs so as to increase their penetration through the cornea. The invention also relates to drugs modified (derivatized) in accordance with the instant method and to the use of same in treating conditions associated with elevated intraocular pressure, particularly, glaucoma.

  本发明一般涉及眼科药物。更具体地，本发明涉及一种修改（衍生化）眼科药物的方法，以增加它们通过角膜的渗透性。本发明还涉及根据本方法修改（衍生化）的药物，以及将其用于治疗与眼内压升高相关的疾病，特别是青光眼。
• OPHTHAMOLOGICAL DRUGS
  申请人：Toone Eric J.

  公开号：US20090318542A1

  公开（公告）日：2009-12-24

  The present invention relates generally to ophthamological drugs. More specifically, the invention relates to a method of modifying (derivatizing) ophthamological drugs so as to increase their penetration through the cornea. The invention also relates to drugs modified (derivatized) in accordance with the instant method and to the use of same in treating conditions associated with elevated intraocular pressure, particularly, glaucoma.

  本发明通常涉及眼科药物。更具体地说，本发明涉及一种改性（衍生化）眼科药物的方法，以增加它们穿过角膜的渗透性。本发明还涉及按照本方法改性（衍生化）的药物，以及将其用于治疗与眼内压升高有关的疾病，特别是青光眼。
• Composition and use of substances for stabilising amino acids containing sulphur
  申请人：——

  公开号：US20040138169A1

  公开（公告）日：2004-07-15

  The invention relates to a composition for the stabilization of sulphur-containing amino acids and/or for the inhibition of the continuous formation of sulphur-containing amino acids in withdrawn blood, to the use of suitable substances and compositions therefor as well as optionally for the determination of sulphur-containing amino acids in blood, to a process for these purposes, as well as to a blood collecting device applied appropriately to these processes.

  本发明涉及一种用于稳定血液中含硫氨基酸和/或抑制血液中含硫氨基酸持续形成的组合物，涉及合适物质及其组合物的使用，以及用于测定血液中含硫氨基酸的选择，涉及用于上述目的的工艺，以及适用于上述工艺的采血装置。
• PRODRUG DERIVATIVES OF CARBOXYLIC ACID DRUGS
  申请人：Bundgaard, Hans

  公开号：EP0278977A1

  公开（公告）日：1988-08-24