(Z)-3-(4-phenoxybenzylidene)-2-(3-methoxypropyl)isoindolin-1-one | 1445679-83-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Z)-3-(4-phenoxybenzylidene)-2-(3-methoxypropyl)isoindolin-1-one
• 英文别名: (3Z)-2-(3-methoxypropyl)-3-[(4-phenoxyphenyl)methylidene]isoindol-1-one
• CAS: 1445679-83-3
• 化学式: C₂₅H₂₃NO₃
• 分子量: 385.463
• InChiKey: SWHSVGUBEDKTQY-MOHJPFBDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-苯氧基苯乙炔 、 在 tris(3-(N,N-dimethylguanidino)phenyl)phosphine trihydrochloride 、 N,N-二异丙基乙胺 、 palladium dichloride 作用下， 以 水 为溶剂， 反应 1.0h， 以78%的产率得到(Z)-3-(4-phenoxybenzylidene)-2-(3-methoxypropyl)isoindolin-1-one
  参考文献：
  名称：

  A green approach for the regio- and stereo-selective syntheses of (Z)-3-methyleneisoindoline-1-ones in aqueous medium

  摘要：

  A high yielding novel methodology was developed for the regio- and stereo-selective syntheses of (Z)-3-methyleneisoindoline-1-ones from substituted 2-phenylethynyl benzamides, generated in situ from 2(phenylcarbamoyl)phenyl-1-H-imidazole-1-sulfonates and corresponding alkyne by Cu-free Sonogashira cross-coupling-5-exo-dig-cyclization in aqueous medium under sonication. The compound could easily be purified by recrystallization from EtOAc without column chromatography. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.05.004

文献信息

• A green approach for the regio- and stereo-selective syntheses of (Z)-3-methyleneisoindoline-1-ones in aqueous medium
  作者：Nivedita Chatterjee、Swarbhanu Sarkar、Rammyani Pal、Asish Kumar Sen

  DOI：10.1016/j.tetlet.2013.05.004

  日期：2013.7

  A high yielding novel methodology was developed for the regio- and stereo-selective syntheses of (Z)-3-methyleneisoindoline-1-ones from substituted 2-phenylethynyl benzamides, generated in situ from 2(phenylcarbamoyl)phenyl-1-H-imidazole-1-sulfonates and corresponding alkyne by Cu-free Sonogashira cross-coupling-5-exo-dig-cyclization in aqueous medium under sonication. The compound could easily be purified by recrystallization from EtOAc without column chromatography. (C) 2013 Elsevier Ltd. All rights reserved.