8-(4'-Nitrophenyl)-octansaeure | 66148-00-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 8-(4'-Nitrophenyl)-octansaeure
• 英文别名: 8-(4-Nitrophenyl)octanoic acid
• CAS: 66148-00-3
• 化学式: C₁₄H₁₉NO₄
• 分子量: 265.309
• InChiKey: CQNVMKBMIPPBJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  83.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  8-(4'-Nitrophenyl)-octansaeure 生成 8-(4'-Nitrophenyl)-octan-saeureamid
  参考文献：
  名称：

  潜在的抗肿瘤药。27.ω-[4-（9-ac啶基氨基）苯基]链烷酸的定量结构-抗白血病（L1210）活性关系。

  摘要：

  9-苯胺基cr啶的简单羧酸衍生物（例如1，R = -COOH）具有很高的实验抗白血病（L1210）活性。同源的1'-（CH2）nCOOH同系物也被证明具有活性，并且L1210试验中寿命的最大增长与用作衡量亲脂性-亲水性平衡剂的Rm值之间存在抛物线关系。相应的羧酰胺[1'-（CH2）nCONH2]具有相似的抛物线关系，具有最佳的Rm值，与酸的值相比有所偏离。较早检查的1'-NHSO2（CH2）nCH3变体，它们的3-NHCOCH3同系物以及羧酰胺[1'-（CH2）nCONH2]和磺酰胺[1'-（CH2）nSO2NH2]同源物可被视为一组得到的相关方程与仅羧酰胺变体的相关方程相同。该组的最佳Rm值与酸的最佳Rm值相等于辛醇-水规模的1.8 log P单位。在该药物系列中，羧酸残基充当可接受的亲水性单元，在未电离的酸和完全电离的羧酸根阴离子之间提供log P贡献中间值。在含有羧酸或链烷磺酰胺侧链

  DOI：

  10.1021/jm00203a005
• 作为产物：
  描述：

  苯乙酰氯 生成 8-(4'-Nitrophenyl)-octansaeure
  参考文献：
  名称：

  潜在的抗肿瘤药。27.ω-[4-（9-ac啶基氨基）苯基]链烷酸的定量结构-抗白血病（L1210）活性关系。

  摘要：

  9-苯胺基cr啶的简单羧酸衍生物（例如1，R = -COOH）具有很高的实验抗白血病（L1210）活性。同源的1'-（CH2）nCOOH同系物也被证明具有活性，并且L1210试验中寿命的最大增长与用作衡量亲脂性-亲水性平衡剂的Rm值之间存在抛物线关系。相应的羧酰胺[1'-（CH2）nCONH2]具有相似的抛物线关系，具有最佳的Rm值，与酸的值相比有所偏离。较早检查的1'-NHSO2（CH2）nCH3变体，它们的3-NHCOCH3同系物以及羧酰胺[1'-（CH2）nCONH2]和磺酰胺[1'-（CH2）nSO2NH2]同源物可被视为一组得到的相关方程与仅羧酰胺变体的相关方程相同。该组的最佳Rm值与酸的最佳Rm值相等于辛醇-水规模的1.8 log P单位。在该药物系列中，羧酸残基充当可接受的亲水性单元，在未电离的酸和完全电离的羧酸根阴离子之间提供log P贡献中间值。在含有羧酸或链烷磺酰胺侧链

  DOI：

  10.1021/jm00203a005

文献信息

• Enzymatic peracid bleaching system
  申请人：The Clorox Company

  公开号：EP0268456A2

  公开（公告）日：1988-05-25

  An enzymatic perhydrolysis system, useful for bleaching, has a novel enzyme, a substrate, and a source of hydrogen peroxide, and provides in situ formation of peracid in aqueous solution. The substrate is selected for enzyme catalyzed reaction, and preferably is an acylglycerol with two or three fatty acid chains. The enzyme is hydrolytically and perhydrolytically active even in the presence of anionic surfactants, has lipase acitivity, and is isolatable from Pseudomonas putida ATCC 53552.

  一种可用于漂白的酶过水解系统具有一种新型酶、一种底物和一种过氧化氢源，可在水溶液中就地形成过酸。底物选择用于酶催化反应，最好是具有两个或三个脂肪酸链的酰基甘油。该酶即使在阴离子表面活性剂存在的情况下也具有水解和过水解活性，具有脂肪酶活性，可从假单胞菌 ATCC 53552 中分离出来。
• Systems and methods for biopolymer engineering
  申请人：DNA TWOPOINTO INC.

  公开号：EP1939779A2

  公开（公告）日：2008-07-02

  Methods, computer systems, and computer program products for biopolymer engineering. A variant set for a biopolymer of interest is constructed by identifying, using a plurality of rules, a plurality of positions in the biopolymer of interest and, for each respective position in the plurality of positions, substitutions for the respective position. The plurality of positions and the substitutions for each respective position in the plurality of positions collectively define a biopolymer sequence space. A variant set comprising a plurality of variants of the biopolymer of interest is selected. A property of all or a portion of the variants in the variant set is measured. A sequence-activity relationship is modeled between (i) one or more substitutions at one or more positions of the biopolymer of interest represented by the variant set and (ii) the property measured for all or the portion of the variants in the variant set. The variant set is redefined to comprise variants that include substitutions in the plurality of positions that are selected based on a function of the sequence-activity relationship.

  用于生物聚合物工程的方法、计算机系统和计算机程序产品。通过使用多条规则确定生物聚合物中的多个位置，并确定多个位置中每个位置的替代物，从而构建相关生物聚合物的变体集。多个位置和多个位置中每个位置的替代物共同定义了一个生物聚合物序列空间。选择一个变体集，该变体集由相关生物聚合物的多个变体组成。测量变体集中所有或部分变体的特性。在以下两者之间建立序列-活性关系模型：(i) 变体集所代表的相关生物聚合物的一个或多个位置上的一个或多个置换；(ii) 针对变体集中所有或部分变体所测量的特性。变体集被重新定义为包括变体，这些变体包括根据序列-活性关系函数选择的多个位置上的取代。
• Method and culture device for detecting yeasts and molds
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US10640743B2

  公开（公告）日：2020-05-05

  A thin film culture device for detecting yeast and mold microorganisms in a sample is provided. The culture device comprises a body comprising a self-supporting substrate having a first major surface and a second major surface; a first adhesive composition disposed on a portion of the first major surface of the substrate; a substantially dry, cold-water-soluble first hydrogel-forming composition adhered to the first adhesive composition; and a plurality of indicator agents. The plurality of indicator agents comprises three indicator agents for detecting distinct glycosidase enzyme activities, an indicator agent for detecting an alkyl esterase enzyme activity, and an indicator agent for detecting a phosphatase enzyme activity, wherein each of the plurality of indicator agents comprises a detectable reporter group. A method of using the culture device is also provided.

  提供了一种用于检测样品中酵母和霉菌微生物的薄膜培养装置。该培养装置包括一个主体，该主体包括具有第一大表面和第二大表面的自支撑基底；设置在基底第一大表面部分上的第一粘合剂组合物；粘附在第一粘合剂组合物上的基本干燥、冷水可溶的第一水凝胶形成组合物；以及多种指示剂。多种指示剂包括三种用于检测不同糖苷酶酶活性的指示剂、一种用于检测烷基酯酶酶活性的指示剂和一种用于检测磷酸酶酶活性的指示剂，其中多种指示剂中的每一种都包括可检测的报告基团。还提供了一种使用该培养装置的方法。
• Article and method for detecting aerobic bacteria
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US11414641B2

  公开（公告）日：2022-08-16

  A thin film culture device for detecting aerobic bacteria in a sample is provided. The culture device comprises a self-supporting substrate sheet having a first major surface and a second major surface; a cover sheet attached to the substrate sheet, a sample-receiving zone disposed between the substrate sheet and the cover sheet, a first layer comprising a substantially dry, cold-water-soluble first hydrogel-forming composition adhered to a portion of the sample-receiving zone; and a plurality of indicator agents disposed in at least one layer adhered to the substrate sheet or the cover sheet. The plurality of indicator agents comprises three indicator agents for detecting distinct glycosidase enzyme activities, an indicator agent for detecting an alkyl esterase enzyme activity, an indicator agent for detecting a phosphatase enzyme activity, and a redox indicator. A method of using the culture device is also provided.

  提供了一种用于检测样品中需氧细菌的薄膜培养装置。该培养装置包括：具有第一大表面和第二大表面的自支撑基片；连接到基片上的盖片，设置在基片和盖片之间的样品接收区，粘附到样品接收区部分的第一层，包括基本干燥、冷水可溶的第一水凝胶形成组合物；以及设置在粘附到基片或盖片上的至少一层中的多种指示剂。多种指示剂包括三种用于检测不同糖苷酶酶活的指示剂、一种用于检测烷基酯酶酶活的指示剂、一种用于检测磷酸酶酶活的指示剂和一种氧化还原指示剂。还提供了一种使用培养装置的方法。
• Method of binding a compound to a surface
  申请人：Hektor Jan Harm

  公开号：US20050238685A1

  公开（公告）日：2005-10-27

  The present invention relates to a method of binding a compound to at least a part of a surface of an object, the method comprising the step of adsorbing a hydrophobin-like substance to the surface. The invention provides a method of providing a surface of an object with a reactive compound comprising the steps of coating at least a part of the surface of the object with a coating of a hydrophobin-like substance and contacting the compound with the coated hydrophobin-like substance to form a non-covalent bond between the hydrophobin-like substance and the compound.

  本发明涉及一种将化合物与物体表面至少一部分结合的方法，该方法包括将疏水性类物质吸附到物体表面的步骤。本发明提供了一种为物体表面提供反应性化合物的方法，该方法包括以下步骤：在物体表面的至少一部分涂上一层类疏水性物质，并将化合物与涂上的类疏水性物质接触，以在类疏水性物质和化合物之间形成非共价键。