3,4,5-三氯-2(1H)-吡啶酮 | 89166-98-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 3,4,5-三氯-2(1H)-吡啶酮
• 中文别名: 2-羟基-3,4,5-三氯吡啶
• 英文名称: 3,4,5-Trichlor-pyridon-(2)
• 英文别名: 3,4,5-Trichloropyridin-2-ol；3,4,5-trichloro-1H-pyridin-2-one
• CAS: 89166-98-3
• 化学式: C₅H₂Cl₃NO
• 分子量: 198.436
• InChiKey: IHZPCKHNCXIHTO-UHFFFAOYSA-N

物化性质

• 沸点：
  222.1±40.0 °C(Predicted)
• 密度：
  1.67±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2933399090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  3,4,5-三氯-2(1H)-吡啶酮 在 palladium on activated charcoal 、 甲酸铵 作用下， 以 乙醇 为溶剂， 反应 5.0h， 以87.3%的产率得到2-羟基吡啶
  参考文献：
  名称：

  一种2-羟基吡啶的制备方法

  摘要：

  本发明涉及医药合成领域，公开了一种2‑羟基吡啶的制备方法，本发明方法以3,5,6‑三氯吡啶醇为原料，经钯/炭催化甲酸铵还原去氯而得。该方法原材料价廉易得，反应条件温和、收率高，后处理简单，三废少，催化剂可回收套用，生产成本低，设备要求低，是小批量生产的快捷途径。

  公开号：

  CN109836372A
• 作为产物：
  描述：

  3,4,5-三氯吡啶-2-胺 在 potassium nitrite 、 硫酸 作用下， 生成 3,4,5-三氯-2(1H)-吡啶酮
  参考文献：
  名称：

  Sell; Dootson, Journal of the Chemical Society, 1900, vol. 77, p. 773

  摘要：

  DOI：

文献信息

• Production of 3,5,6-trichloro-pyridin-2-ol and novel intermediates thereof
  申请人：LUXEMBOURG INDUSTRIES (PAMOL) LTD.

  公开号：EP0341585A1

  公开（公告）日：1989-11-15

  Novel aryl and heteroaryl 4-cyano-2,2,4-trichloro­butyrates are prepared by reacting a corresponding aryl or heteroaryl trichloroacetate with acrylonitrile in the presence of a catalyst. Also provided is a novel process for producing 3,5,6-trichloropyridin-2-ol comprising cyclization of an aryl or heteroaryl 4-cyano-2,2,4-trichlorobutyrate in an inert organic solvent at elevated temperatures, in the presence of anhydrous hydrogen chloride.

  新型芳基和杂芳基 4-氰基-2,2,4-三氯丁酸酯是通过相应的芳基或杂芳基三氯乙酸酯与丙烯腈在催化剂存在下反应制备的。 此外，还提供了一种生产 3,5,6-三氯吡啶-2-醇的新工艺，包括在惰性有机溶剂中，在无水氯化氢存在下，使芳基或杂芳基 4-氰基-2,2,4-三氯丁酸酯在高温下环化。
• An improved process for the preparation of 3,5,6-trichloropyridin-2-ol
  申请人：DowElanco

  公开号：EP0397281A3

  公开（公告）日：1991-10-02

  A process for the preparation of 3,5,6-­trichloropyridin-2-ol from trichloroacetyl chloride and acrylonitrile is improved by separately conducting the individual addition, cyclization and aromatization steps. By separating these steps, water and HCl, which are by-products of the latter steps, can be precluded from interfering with the earlier steps. The individual process steps have also been improved.

  通过分别进行加成、环化和芳香化步骤，改进了从三氯乙酰氯和丙烯腈制备 3,5,6-三氯吡啶-2-醇的工艺。通过分离这些步骤，可以避免后几个步骤的副产品水和盐酸干扰前几个步骤。各个工艺步骤也得到了改进。
• A method of selecting an antibody, a hybridoma, a monoclonal antibody and use thereof
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1258729A2

  公开（公告）日：2002-11-20

  The present invention provides a method of selecting an antibody against a target substance to be measured which comprises selecting the antibody against the target substance by antigen-antibody reaction in the presence of a substance interfering with the antigen-antibody reaction. That is, an antigen and a labeled antigen are reacted with the antibody in the presence of an interfering substance such as an environment pollutant, and on the basis of the degree of reaction thereof, the antibody against the target substance highly resistant to the interfering substance is selected. Thereby, even if a test sample is contaminated with a substance interfering with antigen-antibody reaction, the antibody highly resistant to a substance interfering with antigen-antibody reaction is not influenced by the interfering substance and gives a correct value in the quantification.

  本发明提供了一种针对待测目标物质的抗体选择方法，该方法包括在干扰抗原-抗体反应的物质存在下，通过抗原-抗体反应选择针对目标物质的抗体。 也就是说，在干扰物质（如环境污染物）存在的情况下，抗原和标记抗原与抗体反应，根据反应程度选择对干扰物质具有高度抵抗力的目标物质抗体。这样，即使测试样品被干扰抗原-抗体反应的物质污染，对干扰抗原-抗体反应的物质具有高度抗性的抗体也不会受到干扰物质的影响，并能给出正确的定量值。
• Method of selecting an antibody, a hybridoma, a monoclonal antibody and use thereof
  申请人：——

  公开号：US20030064389A1

  公开（公告）日：2003-04-03

  The present invention provides a method of selecting an antibody against a target substance to be measured which comprises selecting the antibody against the target substance by antigen-antibody reaction in the presence of a substance interfering with the antigen-antibody reaction. That is, an antigen and a labeled antigen are reacted with the antibody in the presence of an interfering substance such as an environment pollutant, and on the basis of the degree of reaction thereof, the antibody against the target substance highly resistant to the interfering substance is selected. Thereby, even if a test sample is contaminated with a substance interfering with antigen-antibody reaction, the antibody highly resistant to a substance interfering with antigen-antibody reaction is not influenced by the interfering substance and gives a correct value in the quantification.

  本发明提供了一种针对待测目标物质的抗体选择方法，该方法包括在干扰抗原-抗体反应的物质存在下，通过抗原-抗体反应选择针对目标物质的抗体。 也就是说，在干扰物质（如环境污染物）存在的情况下，抗原和标记抗原与抗体反应，根据反应程度选择对干扰物质具有高度抵抗力的目标物质抗体。这样，即使测试样品被干扰抗原-抗体反应的物质污染，对干扰抗原-抗体反应的物质具有高度抗性的抗体也不会受到干扰物质的影响，并能给出正确的定量值。
• [EN] PROCESS FOR THE PREPARATION OF 3,3,5-TRICHLOROGLUTARIMIDE<br/>[FR] PROCEDE DE PREPARATION DE 3,3,5-TRICHLOROGLUTARIMIDE
  申请人：DOWELANCO

  公开号：WO1997005112A1

  公开（公告）日：1997-02-13

  (EN) 3,3,5-Trichloroglutarimide is prepared by combining 4-cyano-2,2,4-trichlorobutanoyl chloride with water in an inert organic solvent at a temperature between 20 °C and 50 °C to obtain a mixture of 3,3,5-trichloroglutarimide and 3,3,5,6-tetrachloro-5,6-dihydropyridin-2-one. The 3,3,5,6-tetrachloro-5,6-dihydropyridin-2-one is then heated in the presence of water and inert organic solvent to between 90 °C and 100 °C to convert the 3,3,5,6-tetrachloro-5,6-dihydropyridin-2-one to 3,3,5-trichloroglutarimide.(FR) On prépare du 3,3,5-trichloroglutarimide en associant du chlorure de 4-cyano-2,2,4-trichlorobutanoyle avec de l'eau dans un solvant organique inerte, à une température comprise entre 20 °C et 50 °C, pour obtenir un mélange de 3,3,5-trichloroglutarimide et de 3,3,5,6-tétrachloro-5,6-dihydropyridine-2-one. On porte ensuite la 3,3,5,6-tétrachloro-5,6-dihydropyridin-2-one, en présence d'eau et d'un solvant organique inerte, à une température comprise entre 90 °C et 100 °C, ce qui transforme la 3,3,5,6-tétrachloro-5,6-dihydropyridine-2-one en 3,3,5-trichloroglutarimide.

  三氯酸酐3,3,5-衍生物通过将4-硝基-2,2,4-三氯乙酸氯化物与水结合，并在惰性有机溶剂中进行反应，温度在20°C到50°C之间，得到3,3,5-三氯酸酐和3,3,5,6-四氯-5,6-二氢吡啶-2-酮的混合物。然后，在水中和惰性有机溶剂存在的条件下，对3,3,5,6-四氯-5,6-二氢吡啶-2-酮加热，温度控制在90°C到100°C之间，从而将3,3,5,6-四氯-5,6-二氢吡啶-2-酮转化为3,3,5-三氯酸酐。