申请人：LILLY CO ELI
公开号：WO2005092835A1
公开（公告）日：2005-10-06
The present invention relates to inhibitors of serotonin and/or norepinephrine reuptake and specifically provides compounds of formula (I): wherein A is selected from -O- and -S-; X is selected from C1-C8 alkyl, C2-C8 alkenyl, and C4-C8 cycloalkylalkyl, each of which may be optionally substituted with up to 3 substituents each independently selected from phenyl, pyrrolidinyl, piperidinyl, morpholinyl, halo, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkyl-S(O)n- where n is 0, 1 or 2, -CF3, -CN and -CONH2; Y is selected from (a), (b), (c), (d), (e), (f) where R3, R4 and R5 are independently selected from hydrogen, halo, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkyl-S(O)n- where n is 0, 1 or 2, nitro, acetyl, -CF3, -SCF3 and cyano; R6 and R7 are independently selected from halo, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkyl-S(O)n- where n is 0, 1 or 2, nitro, acetyl, -CF3, -SCF3 and cyano; R8 is selected from chloro, bromo, iodo, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkyl-S(O)n- where n is 0, 1 or 2, nitro, acetyl, -CF3, -SCF3 and cyano; R1 and R2 are each independently hydrogen or C1-C4 alkyl; or pharmaceutically acceptable salts thereof; or compositions thereof and methods of using the same.
本发明涉及5-羟色胺和/或去甲肾上腺素再摄取的抑制剂，具体提供了如下公式(I)的化合物：其中A选自-O-和-S-；X选自C1-C8烷基，C2-C8烯基和C4-C8环烷基烷基，其中每个基团可任选地被最多3个独立选自苯基、吡咯烷基、哌啶基、吗啉基、卤素、C1-C4烷基、C1-C4烷氧基、C1-C4烷基-S(O)n基团取代，其中n为0、1或2，-CF3，-CN和-CONH2；Y选自(a)，(b)，(c)，(d)，(e)，(f)，其中R3、R4和R5独立选自氢、卤素、C1-C4烷基、C1-C4烷氧基、C1-C4烷基-S(O)n基团，其中n为0、1或2，硝基、乙酰基、-CF3，-SCF3和腈；R6和R7独立选自卤素、C1-C4烷基、C1-C4烷氧基、C1-C4烷基-S(O)n基团，其中n为0、1或2，硝基、乙酰基、-CF3，-SCF3和腈；R8选自氯、溴、碘、C1-C4烷基、C1-C4烷氧基、C1-C4烷基-S(O)n基团，其中n为0、1或2，硝基、乙酰基、-CF3，-SCF3和腈；R1和R2各自独立地为氢或C1-C4烷基；或其药用可接受的盐；或其组合物及使用方法。
