1,3,4,6-tetramethyl-2-oxo-1-azacyclohexa-3,5-diene | 80206-56-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1,3,4,6-tetramethyl-2-oxo-1-azacyclohexa-3,5-diene
• 英文别名: 1,3,4,6-Tetramethylpyridin-2-one
• CAS: 80206-56-0
• 化学式: C₉H₁₃NO
• 分子量: 151.208
• InChiKey: CWMKSXXMTGIROD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1,2,4,5-tetramethyl-3-oxo-2-azabicyclo<2.2.0>hex-5-ene 以 苯 为溶剂， 反应 1.5h， 以92%的产率得到1,3,4,6-tetramethyl-2-oxo-1-azacyclohexa-3,5-diene
  参考文献：
  名称：

  One-pot nonphotochemical synthesis of Dewar pyridones from alkynes and isocyanates

  摘要：

  DOI：

  10.1021/jo00345a020

文献信息

• HAIR TREATMENT PRODUCTS COMPRISING POLYMERS
  申请人：Schulze zur Wiesche Erik

  公开号：US20090304620A1

  公开（公告）日：2009-12-10

  The invention relates to hair treatment products, comprising at least one copolymer made of 0.1 to 50% (in relation to the total number of monomers in the copolymer) monomers of the formula (I), wherein the unknowns are defined as in claim 1 , and A2) are monomers from the group of acrylic acid, methacrylic acid and the like, and—optionally non-ionic monomers from the group of acrylamide, vinyl alcohol, and the like, wherein the monomers A2 and A3 together represent 50 to 99.9% (in relation to the total number of monomers in the copolymer) of the copolymer, at least one silicon and at least one selected care product, wherein the products result in advantageous effects for skin and hair.

  该发明涉及头发护理产品，包括至少一种由0.1至50%（相对于共聚物中单体总数的比例）的公式（I）的单体制成的共聚物，其中未知数的定义如权利要求1中定义的，以及A2）是来自丙烯酸、甲基丙烯酸等单体组的单体，以及——可选的非离子单体，来自丙烯酰胺、乙烯醇等单体组，其中单体A2和A3共同代表共聚物中50至99.9%（相对于共聚物中单体总数的比例）的单体，至少含有一种硅和至少一种选定的护理产品，其中这些产品对皮肤和头发具有有利效果。
• Cinnamoyl Compound and Use Thereof
  申请人：Shiraki Hiroaki

  公开号：US20100081652A1

  公开（公告）日：2010-04-01

  Disclosed is an extracellular matrix genetranscription inhibitor composition or the like characterized by containing a cinnamoyl compound represented by the formula (I) below: and an inert carrier.

  本发明涉及一种细胞外基质基因转录抑制剂组合物，其特征在于包含以下式子（I）所表示的肉桂酰化合物和惰性载体。
• FUSED HETEROCYCLIC RING DERIVATIVE AND USE THEREOF
  申请人：Sasaki Satoshi

  公开号：US20120208794A1

  公开（公告）日：2012-08-16

  The present invention provides a fused heterocycle derivative having a strong Smo inhibitory activity, and use thereof. Specially, the present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or salt thereof, and a medicament containing the compound or a prodrug thereof, which is an Smo inhibitor or an agent for the prophylaxis or treatment of cancer.

  本发明提供了一种具有强烈Smo抑制活性的融合杂环衍生物及其应用。具体而言，本发明涉及一种由以下式表示的化合物或其盐，其中每个符号如规范中定义的，以及含有该化合物或其前药的药物，该化合物是Smo抑制剂或癌症预防或治疗剂。
• Use of Cinnamoyl Compound
  申请人：Shiraki Hiroaki

  公开号：US20090143368A1

  公开（公告）日：2009-06-04

  A composition for inhibiting the extracellular matrix gene transcription comprising a cinnamoyl compound represented by the formula (I): and an inert carrier, or the like.

  一种用于抑制细胞外基质基因转录的组合物，包括由式（I）表示的肉桂酰化合物和惰性载体等。
• Quinoline derivatives
  申请人：Gilead Sciences, Inc.

  公开号：US11116760B2

  公开（公告）日：2021-09-14

  The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.

  本公开提供了一种式 (I) 的化合物： 或其药学上可接受的盐。本公开还提供了包含式（I）化合物的药物组合物、制备式（I）化合物的工艺以及治疗炎症性疾病的治疗方法。