4-(1-methylpiperidin-4-yl)oxyspiro[6,7-dihydro-5H-quinazoline-8,1'-cyclopentane]-2-amine | 1227057-06-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-(1-methylpiperidin-4-yl)oxyspiro[6,7-dihydro-5H-quinazoline-8,1'-cyclopentane]-2-amine
• CAS: 1227057-06-8
• 化学式: C₁₈H₂₈N₄O
• 分子量: 316.447
• InChiKey: WGLAOYZEGTWIIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  64.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-甲基-4-哌啶醇 、 2'-amino-6',7'-dihydro-5'H-spiro[cyclopentane-1,8'-quinazoline]-4'-yl 4-methylbenzenesulfonate 在 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 反应 48.0h， 生成 4-(1-methylpiperidin-4-yl)oxyspiro[6,7-dihydro-5H-quinazoline-8,1'-cyclopentane]-2-amine
  参考文献：
  名称：

  Rigidified 2-aminopyrimidines as histamine H4 receptor antagonists: Effects of substitution about the rigidifying ring

  摘要：

  Three novel series of histamine H-4 receptor (H4R) antagonists containing the 2-aminopyrimidine motif are reported. The best of these compounds display good in vitro potency in both functional and binding assays. In addition, representative compounds are able to completely block itch responses when dosed ip in a mouse model of H-4-agonist induced scratching, thus demonstrating their activities as H4R antagonists. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.01.131

文献信息

• Rigidified 2-aminopyrimidines as histamine H4 receptor antagonists: Effects of substitution about the rigidifying ring
  作者：John R. Koenig、Huaqing Liu、Irene Drizin、David G. Witte、Tracy L. Carr、Arlene M. Manelli、Ivan Milicic、Marina I. Strakhova、Thomas R. Miller、Timothy A. Esbenshade、Jorge D. Brioni、Marlon Cowart

  DOI：10.1016/j.bmcl.2010.01.131

  日期：2010.3

  Three novel series of histamine H-4 receptor (H4R) antagonists containing the 2-aminopyrimidine motif are reported. The best of these compounds display good in vitro potency in both functional and binding assays. In addition, representative compounds are able to completely block itch responses when dosed ip in a mouse model of H-4-agonist induced scratching, thus demonstrating their activities as H4R antagonists. (C) 2010 Elsevier Ltd. All rights reserved.