N-[(4-cyanophenyl)-(2,4,6-trimethoxyphenyl)methyl]-4-methylbenzenesulfonamide | 1236810-88-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[(4-cyanophenyl)-(2,4,6-trimethoxyphenyl)methyl]-4-methylbenzenesulfonamide
• CAS: 1236810-88-0
• 化学式: C₂₄H₂₄N₂O₅S
• 分子量: 452.531
• InChiKey: IJDZSMPBPPIKJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  106
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  1,3,5-三甲氧基苯 、 N-[(4-氰基苯基)亚甲基]-4-甲基苯磺酰胺 在 [Ru(TBPP)](SbF₆)₂ 作用下， 以 甲苯 为溶剂， 反应 1.0h， 以94%的产率得到N-[(4-cyanophenyl)-(2,4,6-trimethoxyphenyl)methyl]-4-methylbenzenesulfonamide
  参考文献：
  名称：

  RUTHENIUM PORPHYRIN CATALYZED FRIEDEL–CRAFTS TYPE REACTION OF ARENES WITH IMINES

  摘要：

  Cationic ruthenium porphyrin complex was found to be an efficient catalyst for the Friedel-Crafts type reaction of arenes with imines. The use of a structurally rigid tetradentate porphyrin as the equatorial ligand and weakly coordinating axial ligand is the key to bring out the catalytic reactivity of ruthenium for the reaction.

  DOI：

  10.3987/com-12-12556

文献信息

• Friedel−Crafts Arylation Reactions of <i>N</i>-Sulfonyl Aldimines or Sulfonamidesulfones with Electron-Rich Arenes Catalyzed by FeCl₃·6H₂O: Synthesis of Triarylmethanes and Bis-heteroarylarylmethanes
  作者：Ponnaboina Thirupathi、Sung Soo Kim

  DOI：10.1021/jo1010137

  日期：2010.8.6

  The FeCl3 center dot 6H(2)O-catalyzed Friedel-Crafts arylation reactions of N-sulfonyl aldimines or sulfonamidesulfones with electron-rich arenes and heteroarenes, which lead to the formation of triarylmethanes and bis-heteroarylarylmethanes, are developed. The use of mild reaction conditions, low catalytic loading, high yield, and single step synthesis are the advantages of the present procedure.
• RUTHENIUM PORPHYRIN CATALYZED FRIEDEL–CRAFTS TYPE REACTION OF ARENES WITH IMINES
  作者：Takuya Kurahashi、Seijiro Matsubara、Takuma Terada

  DOI：10.3987/com-12-12556

  日期：——

  Cationic ruthenium porphyrin complex was found to be an efficient catalyst for the Friedel-Crafts type reaction of arenes with imines. The use of a structurally rigid tetradentate porphyrin as the equatorial ligand and weakly coordinating axial ligand is the key to bring out the catalytic reactivity of ruthenium for the reaction.