3,4-二氢吡啶-2-羧酸 | 139549-65-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 3,4-二氢吡啶-2-羧酸
• 英文名称: Dihydropicolinic acid
• 英文别名: 3,4-dihydropyridine-2-carboxylic acid
• CAS: 139549-65-8
• 化学式: C₆H₇NO₂
• 分子量: 125.13
• InChiKey: FIZUQXLGABRGSR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  49.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] COMPOUNDS FOR THE MODULATION OF MYC ACTIVITY<br/>[FR] COMPOSÉS POUR LA MODULATION DE L'ACTIVITÉ DE MYC
  申请人：SYROS PHARMACEUTICALS INC

  公开号：WO2016197078A1

  公开（公告）日：2016-12-08

  The present invention provides novel compounds of Formula (I) and Formula (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases, e.g., cancers (e.g., breast cancer, prostate cancer, lymphoma, lung cancer, pancreatic cancer, ovarian cancer, neuroblastoma, or colorectal cancer), benign neoplasms, angio genesis, inflammatory diseases, fibrosis (e.g., polycystic kidney disease), autoinflammatory diseases, and autoimmune diseases in a subject.

  本发明提供了式（I）和式（II）的新化合物以及药学上可接受的盐、溶剂合物、水合物、互变异构体、立体异构体、同位素标记衍生物及其组合物。还提供了涉及这些化合物或组合物用于治疗或预防增生性疾病的方法和试剂盒，例如癌症（如乳腺癌、前列腺癌、淋巴瘤、肺癌、胰腺癌、卵巢癌、神经母细胞瘤或结肠直肠癌）、良性肿瘤、血管生成、炎症性疾病、纤维化（如多囊肾病）、自身炎症性疾病和自身免疫疾病的方法。
• [EN] 4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDINE SUMO INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE 4,5,6,7-TÉTRAHYDROTHIÉNO[2,3-C]PYRIDINE SUMO ET LEURS UTILISATIONS
  申请人：ONCOVALENT THERAPEUTICS INC

  公开号：WO2021150918A1

  公开（公告）日：2021-07-29

  The present invention relates to compounds and compositions capable of acting as inhibitors of small ubiquitin-like modifier (SUMO) family of proteins. The compounds and compositions may be used in the treatment of cancer. There are disclosed, inter alia, methods of inhibiting an E1 enzyme, and compounds useful for inhibiting an E1 enzyme.

  本发明涉及能够作为小泛素样修饰物（SUMO）蛋白抑制剂的化合物和组合物。这些化合物和组合物可用于癌症的治疗。其中披露了抑制E1酶的方法，以及用于抑制E1酶的化合物。
• STREPTOGRAMINS AND METHOD FOR PREPARING SAME BY MUTASYNTHESIS
  申请人：Aventis Pharma, S.A.

  公开号：US20020142947A1

  公开（公告）日：2002-10-03

  Novel group B streptogramine-like compounds of general formula (I), and a method for preparing streptogramines by muta-synthesis using a mutated micro-organism to influence the biosynthesis of at least one of the precursors of group B streptogramines, are disclosed. Novel nucleotide sequences involved in the biosynthesis of said precursors, and their uses, are also disclosed.

  本发明公开了通式(I)的新型B组链球菌素类化合物，以及通过使用突变的微生物进行muta合成来影响B组链球菌素的至少一个前体的生物合成的制备方法。还公开了参与所述前体生物合成的新型核苷酸序列及其用途。
• DNA diagnostics based on mass spectrometry
  申请人：SEQUENOM, INC.

  公开号：EP1352971A2

  公开（公告）日：2003-10-15

  The invention provides fast and highly accurate mass spectrometer based processes for detecting a particular nucleic acid sequence in a biological sample. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a predisposition to a disease or condition, infection by a pathogenic organism, or for determining identity or heredity.

  本发明提供了基于质谱仪的快速、高精度流程，用于检测生物样本中的特定核酸序列。根据要检测的序列，这些过程可用于诊断遗传疾病或染色体异常、疾病或病症的易感性、病原体感染或确定身份或遗传性等。
• DNA Diagnostics based on mass spectrometry
  申请人：SEQUENOM, INC.

  公开号：EP2071042A1

  公开（公告）日：2009-06-17

  The invention provides fast and highly accurate mass spectrometer based processes for detecting a particular nucleic acid sequence in a biological sample. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a predisposition to a disease or condition, infection by a pathogenic organism, or for determining identity or heredity.

  本发明提供了基于质谱仪的快速、高精度流程，用于检测生物样本中的特定核酸序列。根据要检测的序列，这些过程可用于诊断遗传疾病或染色体异常、疾病或病症的易感性、病原体感染或确定身份或遗传性等。