3,4-二羟基扁桃腈 | 51688-49-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 3,4-二羟基扁桃腈
• 英文名称: (+/-)-3,4-dihydroxybenzaldehyde cyanohydrin
• 英文别名: 3,4-dihydroxymandelonitrile；3,4-Dihydroxybenzaldehydcyanhydrin；3.4-Dihydroxy-DL-mandelsaeure-nitril；Protocatechualdehyd-cyanhydrin；3.4.α-Trioxy-phenylessigsaeure-nitril；2-(3,4-dihydroxyphenyl)-2-hydroxyacetonitrile
• CAS: 51688-49-4
• 化学式: C₈H₇NO₃
• 分子量: 165.148
• InChiKey: CRISWXPNFWRXSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  84.5
• 氢给体数：
  3
• 氢受体数：
  4

安全信息

• 海关编码：
  2926909090

反应信息

• 作为反应物：
  描述：

  3,4-二羟基扁桃腈 在 盐酸 、 sodium amalgam 、 乙醇 作用下， 生成 DL-去甲肾上腺素
  参考文献：
  名称：

  DE193634

  摘要：

  公开号：
• 作为产物：
  描述：

  氢氰酸 在 potassium carbonate 作用下， 生成 3,4-二羟基扁桃腈
  参考文献：
  名称：

  DE193634

  摘要：

  公开号：

文献信息

• Regulatory sequence for plants
  申请人：CERES, INC.

  公开号：US10329575B2

  公开（公告）日：2019-06-25

  The present invention provides DNA molecules as shown in SEQ ID NO:2199 that constitute fragments of the genome of a plant. The DNA molecules are useful for specifying a gene product in cells as regulatory sequences. One of ordinary skill in the art, having this data, can obtain cloned DNA fragments, synthetic DNA fragments or polypeptides constituting desired sequences by recombinant methodology known in the art or described therein.

  本发明提供如 SEQ ID NO:2199 所示的 DNA 分子，它们构成植物基因组的片段。这些 DNA 分子可作为调控序列用于指定细胞中的基因产物。掌握这些数据的本领域普通技术人员可以通过本领域已知的或其中描述的重组方法获得克隆 DNA 片段、合成 DNA 片段或构成所需序列的多肽。
• Sequence-determined DNA fragments and corresponding polypeptides encoded thereby
  申请人：Alexandrov Nickolai

  公开号：US20060048240A1

  公开（公告）日：2006-03-02

  The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in cells, either as a promoter or as a protein coding sequence or as an UTR or as a 3′ termination sequence, and are also useful in controlling the behavior of a gene in the chromosome, in controlling the expression of a gene or as tools for genetic mapping, recognizing or isolating identical or related DNA fragments, or identification of a particular individual organism, or for clustering of a group of organisms with a common trait. One of ordinary skill in the art, having this data, can obtain cloned DNA fragments, synthetic DNA fragments or polypeptides constituting desired sequences by recombinant methodology known in the art or described herein.

  本发明提供了构成植物基因组片段的DNA分子及其编码的多肽。这些 DNA 分子可作为启动子或蛋白质编码序列或 UTR 或 3′终止序列，用于指定细胞中的基因产物，也可用于控制染色体中基因的行为，控制基因的表达，或作为基因绘图、识别或分离相同或相关 DNA 片段、或识别特定生物个体或具有共同性状的生物群体的工具。掌握这些数据的本领域普通技术人员可以通过本领域已知的或本文所述的重组方法获得克隆 DNA 片段、合成 DNA 片段或构成所需序列的多肽。
• Synthesis of the Adrenergic Bronchodilators (<i>R</i>)-Terbutaline and (<i>R</i>)-Salbutamol from (<i>R</i>)-Cyanohydrins¹
  作者：Franz Effenberger、Jürgen Jäger

  DOI：10.1021/jo970032d

  日期：1997.6.13

  Stereoselective syntheses of (R)-terbutaline and (R)-salbutamol acetal, which are important bronchodilators, starting from O-protected (R)-cyanohydrins are described. (R)-Terbutaline hydrochloride (R)-9.HCl is obtained in an overall yield of 44% with >98% ee from the O-bisallyl-protected cyanohydrin (R)-4k via a Ritter N-tertiary butylation to the amide (R)-6a, hydrogenation to the amino alcohol (R)-7a, and deprotection of the hydroxyl functions. (R)-Salbutamol acetals (R)-7b,c can be obtained from the corresponding O-protected (R)-cyanohydrins either via the route described for (R)-terbutaline or via selective hydrogenation of the protected cyanohydrin (R)-11 to the imino derivative, transimination with tert-butylamine, followed by hydrogenation with NaBH4 to give the 2-amino alcohol derivative (R)-12. Desilylation of(R)-12 to (R)-7c is performed with LiAlH4. Hydrolytic cleavage of the acetals (R)-7b and c to (R)-salbutamol was not yet possible without racemization.
• Rosenmund; Pfannkuch, Chemische Berichte, 1922, vol. 55, p. 2372
  作者：Rosenmund、Pfannkuch

  DOI：——

  日期：——
• Sequence-determined DNA fragments and corresponding polypeptides encoded therapy
  申请人：Alexandrov Nickolai

  公开号：US20090265815A1

  公开（公告）日：2009-10-22

  The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in cells, either as a promoter or as a protein coding sequence or as an UTR or as a 3′ termination sequence, and are also useful in controlling the behavior of a gene in the chromosome, in controlling the expression of a gene or as tools for genetic mapping, recognizing or isolating identical or related DNA fragments, or identification of a particular individual organism, or for clustering of a group of organisms with a common trait. One of ordinary skill in the art, having this data, can obtain cloned DNA fragments, synthetic DNA fragments or polypeptides constituting desired sequences by recombinant methodology known in the art or described herein