3,4-二羟基邻苯二甲酸 | 82784-82-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3,4-二羟基邻苯二甲酸
• 中文别名: 1,2,4-三嗪-5,6-二胺
• 英文名称: 3,4-dihydroxyphthalic acid
• 英文别名: 3,4-dihydroxy-phthalic acid；3.4-Dioxy-benzol-dicarbonsaeure-(1.2)；Brenzcatechin-dicarbonsaeure-(3.4)；3,4-Dihydroxy-phthalsaeure；Norhemipinsaeure；nor-Hemipinsaeure
• CAS: 82784-82-5
• 化学式: C₈H₆O₆
• 分子量: 198.132
• InChiKey: QXGJCWSBOZXWOV-UHFFFAOYSA-N

物化性质

• 沸点：
  487.2±45.0 °C(Predicted)
• 密度：
  1.779±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  115
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3,4-二羟基邻苯二甲酸 生成 4,5-二羟基-2-苯并呋喃-1,3-二酮
  参考文献：
  名称：

  Freund; Horst, Chemische Berichte, 1894, vol. 27, p. 333

  摘要：

  DOI：
• 作为产物：
  描述：

  3,4-二甲氧酞酸 在 五氯化磷 作用下， 生成 3,4-二羟基邻苯二甲酸
  参考文献：
  名称：

  Freund; Horst, Chemische Berichte, 1894, vol. 27, p. 333

  摘要：

  DOI：

文献信息

• Benzoxazole Derivatives Having Inhibitory Activity Against Interleukin-6, Preparation Method Thereof, and Pharmaceutical Composition Containing the Same
  申请人：Park Choo Hea Young

  公开号：US20130090480A1

  公开（公告）日：2013-04-11

  The present invention relates to benzoxazole derivatives represented by the Formula 1, which has an inhibitory activity against interleukin-6 (IL-6), a method for preparation thereof, and a pharmaceutical composition containing the same. The compound represented by the Formula 1 according to the present invention has a superior inhibitory activity against interleukin-6, and therefore, can be practically applied for prevention and treatment of diseases caused by abnormal interleukin-6 activity.

  本发明涉及由公式1表示的苯并噁唑衍生物，其具有对白细胞介素-6（IL-6）的抑制活性，以及其制备方法和含有该化合物的药物组合物。根据本发明的公式1所表示的化合物具有优越的抑制白细胞介素-6的活性，因此，可以实际应用于预防和治疗由异常白细胞介素-6活性引起的疾病。
• Lipophilic electrophoretic probes
  申请人：——

  公开号：US20040022843A1

  公开（公告）日：2004-02-05

  Compounds, compositions, and methods for labeling membranes are disclosed. Compounds of formula G-L-E are described wherein G is a lipophilic group, L is a cleavable linkage and E is an electrophoretic group. The compounds become associated with membranes, and can be cleaved with a cleavage-inducing moiety thereby releasing the detectable electrophoretic group.

  本发明公开了用于标记膜的化合物、组合物和方法。其中，描述了公式G-L-E的化合物，其中G是一个亲脂性基团，L是一个可断裂的连接基团，E是一个电泳基团。这些化合物与膜相关联，并且可以通过断裂诱导基团进行断裂，从而释放可检测的电泳基团。
• Compositions and methods employing cleavable electrophoretic tag reagents
  申请人：Aclara BioSciences, Inc.

  公开号：US20020142329A1

  公开（公告）日：2002-10-03

  Probe sets for the multiplexed detection of the binding of, or interaction between, one or more ligands and target antiligands are provided. Detection involves the release of identifying tags as a consequence of target recognition. The probe sets include electrophoretic tag probes or e-tag probes, comprising a detection region and a mobility-defining region called the mobility modifier, both linked to a target-binding moiety. Target antiligands are contacted with a set of e-tag probes and the contacted antiligands are treated with a selected cleaving agent resulting in a mixture of e-tag reporters and uncleaved and/or partially cleaved e-tag probes. The mixture is exposed to a capture agent effective to bind to uncleaved or partially cleaved e-tag probes, followed by electrophoretic separation. In a multiplexed assay, different released e-tag reporters may be separated and detected providing for target identification. The methods employ compositions comprising luminescent molecules such as, for example, fluorescent molecules, which are modified to provide for electrophoretic properties that differ for each modified luminescent molecule while maintaining substantially the same absorption, emission and quantum yield properties of the original luminescent molecule. The compositions may be cleavably linked to binding molecules to form the e-tag probes.

  提供了一种用于多重检测一种或多种配体与靶抗配体结合或相互作用的探针集。检测涉及到由于靶标识别而释放鉴别标记。该探针集包括电泳标记探针或e-tag探针，包括检测区域和称为迁移修饰因子的迁移定义区域，两者都连接到靶标结合基团。将靶抗配体与一组e-tag探针接触，并用选择的切割剂处理接触到的抗配体，导致e-tag报告物和未切割和/或部分切割的e-tag探针的混合物。混合物接触到有效结合到未切割或部分切割的e-tag探针的捕获剂，然后进行电泳分离。在多重检测中，不同的释放的e-tag报告物可以被分离和检测，从而实现靶标的识别。该方法采用包含发光分子的组合物，例如荧光分子，这些分子被修改以提供每种修改后的发光分子的电泳特性，同时保持原始发光分子的吸收、发射和量子产率特性基本相同。这些组合物可以与结合分子可剪切地连接以形成e-tag探针。
• Methods and compositions for analyzing proteins
  申请人：——

  公开号：US20030013126A1

  公开（公告）日：2003-01-16

  Methods, compositions and kits are disclosed for determining one or more target polypeptides in a sample where the target polypeptides have undergone a post-translational modification. A mixture comprising the sample and a first reagent comprising a cleavage-inducing moiety and a first binding agent for a binding site on a target polypeptide is subjected to conditions under which binding of respective binding moieties occurs. The binding site is the result of post-translational modification activity involving the target polypeptide. The method may be employed to determine the target polypeptide itself. In another embodiment the presence and/or amount of the target polypeptide is related to the presence and/or amount and/or activity of an agent such as an enzyme involved in the post-translational modification of the target polypeptide. The interaction between the first binding agent and the binding site brings the cleavage-inducing moiety into close proximity to a cleavable moiety, which is associated with the polypeptide and is susceptible to cleavage only when in proximity to the cleavage-inducing moiety. In this way, an electrophoretic tag for each of the polypeptides may be released. Released electrophoretic tags are separated and the presence and/or amount of the target polypeptides are determined based on the corresponding electrophoretic tags.

  本发明揭示了一种用于确定样品中经历了翻译后修饰的一个或多个目标多肽的方法、组合物和试剂盒。将包含样品和第一试剂的混合物暴露在相应的结合物质发生结合的条件下，其中第一试剂包括一个裂解诱导基团和一个与目标多肽上的结合位点结合的第一结合剂。该结合位点是涉及目标多肽的翻译后修饰活性的结果。该方法可用于确定目标多肽本身。在另一实施例中，目标多肽的存在和/或数量与参与目标多肽翻译后修饰的酶等试剂的存在、数量和/或活性相关。第一结合剂和结合位点之间的相互作用将裂解诱导基团带到可裂解基团的近距离位置，后者与多肽相关，并且只有在接近裂解诱导基团时才易于裂解。通过这种方式，每个多肽的电泳标签可以被释放。释放的电泳标签被分离，并根据相应的电泳标签确定目标多肽的存在和/或数量。
• METHODS AND COMPOSITIONS FOR ENHANCING DETECTION IN DETERMINATIONS EMPLOYING CLEAVABLE ELECTROPHORETIC TAG REAGENTS
  申请人：Aclara BioSciences, Inc.

  公开号：US20040096825A1

  公开（公告）日：2004-05-20

  Probe sets for the multiplexed detection of the binding of, or interaction between, one or more ligands and target antiligands are provided. Detection involves the release of identifying tags as a consequence of target recognition. The probe sets include electrophoretic tag probes or e-tag probes, comprising a detection region and a mobility-defining region called the mobility modifier, both linked to a target-binding moiety. The probes comprise interactive functionalities adjacent the cleaved portion positioned in the probes such that the interactive functionality does not form part of the e-tag reporters. Target antiligands are contacted with a set of e-tag probes and the contacted antiligands are treated with a selected cleaving agent resulting in a mixture of e-tag reporters and uncleaved and/or partially cleaved e-tag probes. The mixture is exposed to a capture agent effective to bind to uncleaved or partially cleaved e-tag probes, followed by electrophoretic separation. In a multiplexed assay, different released e-tag reporters may be separated and detected providing for target identification.

  提供了一种用于多重检测一种或多种配体与目标抗配体之间的结合或相互作用的探针集。检测涉及由于目标识别而释放识别标签。探针集包括电泳标签探针或e标签探针，包括一个检测区域和一个称为迁移修饰剂的迁移定义区域，两者都链接到一个目标结合部位。探针包括与探针中定位的割裂部分相邻的交互功能，使得交互功能不构成e标签报告者的一部分。将目标抗配体与一组e标签探针接触，并用所选的切割剂处理接触的抗配体，从而产生e标签报告者和未割裂和/或部分割裂的e标签探针的混合物。将混合物暴露于有效结合到未割裂或部分割裂的e标签探针的捕获剂后进行电泳分离。在多重检测中，可以分离和检测不同的释放的e标签报告者，从而实现目标识别。