申请人:Hamada Takayuki
公开号:US20070032658A1
公开(公告)日:2007-02-08
Optically active diphenylalanine compounds may be conveniently prepared in a good yield by reacting a diphenylalanine compound represented by formula (1) with an optically active amine compound represented by formula (2) in the presence of an organic solvent to give a diastereomeric salt represented by formula (5) and then treating the diastereomeric salt under acidic conditions to give an optically active diphenylalanine compound represented by formula (3):
wherein each symbol is as defined in the specification.
光学活性的双苯丙氨酸化合物可通过在有机溶剂存在下,将式(1)表示的双苯丙氨酸化合物与式(2)表示的光学活性胺基化合物反应,得到式(5)表示的对映异构盐,然后在酸性条件下处理对映异构盐,得到式(3)表示的光学活性双苯丙氨酸化合物。其中,每个符号如规范中定义。