5-[[2-[(2-Cyclohexyl-5-methyl-1,3-oxazol-4-yl)methyl]-1-benzofuran-5-yl]methyl]-1,3-oxazolidine-2,4-dione | 136058-63-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 5-[[2-[(2-Cyclohexyl-5-methyl-1,3-oxazol-4-yl)methyl]-1-benzofuran-5-yl]methyl]-1,3-oxazolidine-2,4-dione
• CAS: 136058-63-4
• 化学式: C₂₃H₂₄N₂O₅
• 分子量: 408.454
• InChiKey: NCAKHTZAZFEUOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  94.6
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-(5-Bromo-benzofuran-2-ylmethyl)-2-cyclohexyl-5-methyl-oxazole 在 palladium on activated charcoal 甲酸 、 aluminum nickel 、 氢气 、 sodium acetate 、 间氯过氧苯甲酸 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 25.0~150.0 ℃ 、275.79 kPa 条件下， 反应 24.0h， 生成 5-[[2-[(2-Cyclohexyl-5-methyl-1,3-oxazol-4-yl)methyl]-1-benzofuran-5-yl]methyl]-1,3-oxazolidine-2,4-dione
  参考文献：
  名称：

  Benzyloxazolidine-2,4-diones as potent hypoglycemic agents

  摘要：

  A series of benzyloxazolidine-2,4-diones, containing oxazole-based side chains, were found to lower blood glucose levels in the genetically obese ob/ob mouse. Incorporation of a benzofuran structural element in these compounds provides greatly enhanced in vivo potency. The syntheses and structure-activity relationships for this series are detailed.

  DOI：

  10.1021/jm00109a003

文献信息

• Benzyloxazolidine-2,4-diones as potent hypoglycemic agents
  作者：Robert L. Dow、Bruce M. Bechle、Thomas T. Chou、David A. Clark、Bernard Hulin、Ralph W. Stevenson

  DOI：10.1021/jm00109a003

  日期：1991.5

  A series of benzyloxazolidine-2,4-diones, containing oxazole-based side chains, were found to lower blood glucose levels in the genetically obese ob/ob mouse. Incorporation of a benzofuran structural element in these compounds provides greatly enhanced in vivo potency. The syntheses and structure-activity relationships for this series are detailed.