1,3-dihydroxy-2,4,4-trimethyl-5-phenylimidazolidine | 61934-11-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 1,3-dihydroxy-2,4,4-trimethyl-5-phenylimidazolidine
• 英文别名: 2,4,4-trimethyl-5-phenyl-imidazolidine-1,3-diol
• CAS: 61934-11-0
• 化学式: C₁₂H₁₈N₂O₂
• 分子量: 222.287
• InChiKey: JNQGEKISSDBCLR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  46.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,3-dihydroxy-2,4,4-trimethyl-5-phenylimidazolidine 在 盐酸羟胺 作用下， 以 乙醇 为溶剂， 反应 8.0h， 以78%的产率得到1,2-bishydroxylamino-2-methyl-1-phenylpropane
  参考文献：
  名称：

  Synthesis of aliphatic 1,2-bishydroxylamines from 1,3- dihydroxyimidazolidines.

  摘要：

  Reduction of 1-hydroxy-3-imidazoline-3-oxides with NaBH4 gives 1,3-dihydroxyimidazolidines. The latter on subsequent treatment with NH2OH.HCl in EtOH or in hydrochloric acid afford 1,2-bishydroxylamines. An X-ray study of 1,2-bishydroxylaminocycloalkanes has shown them to be cis-configurated.

  DOI：

  10.1007/bf00698944
• 作为产物：
  描述：

  1-hydroxy-2,5,5-trimethyl-4-phenyl-3-imidazoline 3-oxide 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 反应 25.0h， 生成 2-(N-ethylhydroxylamino)-2-methyl-1-phenyl-1-propanonoxime 、 1,3-dihydroxy-2,4,4-trimethyl-5-phenylimidazolidine
  参考文献：
  名称：

  Synthesis of aliphatic 1,2-bishydroxylamines from 1,3- dihydroxyimidazolidines.

  摘要：

  Reduction of 1-hydroxy-3-imidazoline-3-oxides with NaBH4 gives 1,3-dihydroxyimidazolidines. The latter on subsequent treatment with NH2OH.HCl in EtOH or in hydrochloric acid afford 1,2-bishydroxylamines. An X-ray study of 1,2-bishydroxylaminocycloalkanes has shown them to be cis-configurated.

  DOI：

  10.1007/bf00698944

文献信息

• Synthesis of aliphatic 1,2-bishydroxylamines from 1,3- dihydroxyimidazolidines.
  作者：D. G. Mazhukin、A. Ya. Tikhonov、L. B. Volodarskii、E. P. Konovalova、L. A. Tikhonova、I. Yu. Bagryanskaya、Yu. V. Gatilov

  DOI：10.1007/bf00698944

  日期：1993.5

  Reduction of 1-hydroxy-3-imidazoline-3-oxides with NaBH4 gives 1,3-dihydroxyimidazolidines. The latter on subsequent treatment with NH2OH.HCl in EtOH or in hydrochloric acid afford 1,2-bishydroxylamines. An X-ray study of 1,2-bishydroxylaminocycloalkanes has shown them to be cis-configurated.