3,5-二甲氧基苄肼 | 887596-61-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3,5-二甲氧基苄肼
• 英文名称: 3,5-dimethoxybenzohydrazine
• 英文别名: 3,5-dimethoxybenzylhydrazine；3,5-Dimethoxy-benzyl-hydrazine；(3,5-dimethoxyphenyl)methylhydrazine
• CAS: 887596-61-4
• 化学式: C₉H₁₄N₂O₂
• 分子量: 182.222
• InChiKey: CYMHZIZPJZFOTR-UHFFFAOYSA-N

物化性质

• 沸点：
  358.2±32.0 °C(Predicted)
• 密度：
  1.096±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  56.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3,5-二甲氧基苄肼 、 5-溴水杨醛 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and structure of amide oxygen-bridged polymeric and monomeric copper(II) complexes with aroylhydrazones

  摘要：

  The synthesis and structure of two Cu(II) complexes, {[Cu-2(L-1)(2)]center dot DMF}(n) (1) and [CuL2(phen)] (2), are described. The dinegative hydrazones are obtained by deprotonation of both phenolic and amide moieties of N'-(5-bromo-2-hydroxybenzylidene)-3,5-dimethoxybenzohydrazide (H2L1) and N'-(2-hydroxybenzylidene)pyrazine-2-carbohydrazide (H2L2). In each complex the planar ligand binds the metal ion via phenolate-O, imine-N, and amide-O. Complex 1 is a polymer in which phenoxo-bridged binuclear Cu(II) units are further joined by equatorial-apical amide-O bridges. The Cu center dot center dot center dot Cu separations are 3.0306 and 3.8217 angstrom for the phenolate-O bridged pair and the amide-O bridged pair, respectively. Complex 2 is a monomer where chelating phen displays axial-equatorial bonding, with square-pyramidal Cu(II).

  DOI：

  10.1080/00958972.2012.704550

文献信息

• Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors
  申请人：Nerviano Medical Sciences S.R.L.

  公开号：US10280176B2

  公开（公告）日：2019-05-07

  Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

  本发明公开了说明书中定义的式(Ia)或(Ib)的吡唑-喹唑啉衍生物及其药学上可接受的盐、其制备工艺和包含它们的药物组合物；本发明的化合物在治疗中可用于治疗与蛋白激酶活性紊乱有关的疾病，如癌症。
• PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS
  申请人：Nerviano Medical Sciences, S.R.L.

  公开号：US20170050972A1

  公开（公告）日：2017-02-23

  Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
• US3950528A
  申请人：——

  公开号：US3950528A

  公开（公告）日：1976-04-13
• US4061653A
  申请人：——

  公开号：US4061653A

  公开（公告）日：1977-12-06
• US4076943A
  申请人：——

  公开号：US4076943A

  公开（公告）日：1978-02-28