dibutyl[2-(methylamino)ethyl]amine | 99991-12-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: dibutyl[2-(methylamino)ethyl]amine
• 英文别名: N,N-dibutyl-N'-methyl-ethylenediamine；N,N-Dibutyl-N'-methyl-aethylendiamin；N-Methyl-N',N'-dibutyl-ethylendiamin；N',N'-dibutyl-N-methylethane-1,2-diamine
• CAS: 99991-12-5
• 化学式: C₁₁H₂₆N₂
• 分子量: 186.341
• InChiKey: GBPNNNSVOMWEFH-UHFFFAOYSA-N

物化性质

• 沸点：
  91-91.7 °C(Press: 7-8 Torr)
• 密度：
  0.8125 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  dibutyl[2-(methylamino)ethyl]amine 、 硫代异氰酸苯酯 生成 N-(2-dibutylamino-ethyl)-N-methyl-N'-phenyl-thiourea
  参考文献：
  名称：

  Munch; Thannhauser; Cottle, Journal of the American Chemical Society, 1946, vol. 68, p. 1298

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(二丁氨基)乙醇 在 盐酸 、 氯化亚砜 、 sodium nitrite 、 苯 作用下， 生成 dibutyl[2-(methylamino)ethyl]amine
  参考文献：
  名称：

  Munch; Thannhauser; Cottle, Journal of the American Chemical Society, 1946, vol. 68, p. 1298

  摘要：

  DOI：

文献信息

• Asymmetric synthesis catalyzed by chiral ferrocenylphosphine transition metal complexes. 10 gold(i)-catalyzed asymmetric aldol reaction of isocyanoacetate
  作者：Tamio Hayashi、Masaya Sawamura、Yoshihiko Ito

  DOI：10.1016/s0040-4020(01)88870-0

  日期：1992.1

  Optically active ferrocenylbisphosphine ligands containing 2-(dialkylamino)ethylamino group on the ferrocenylmethyl position have been prepared and used for the gold(I)-catalyzed asymmetric aldol reaction of isocyanoacetate with aldehydes. Six-membered ring amines, such as morpholino or piperidino group, at the terminal of the side chain were most stereoselective to give optically active trans-4-

  制备了在二茂铁基甲基位置上含有2-（二烷基氨基）乙基氨基的旋光二茂铁基双膦配体，并将其用于金（I）催化的异氰基乙酸酯与醛的不对称醛醇缩合反应。侧链末端的六元环胺（例如吗啉代或哌啶子基）具有最高的立体选择性，可生成具有高对映体的光学活性反式-4-甲氧羰基-5-烷基-2-恶唑啉（ee最高可达97％） -和非对映选择性的定量收率。
• [EN] METHOD OF PREPARING POLY(ALKYLENE CARBONATE) VIA COPOLYMERIZATION OF CARBON DIOXIDE/EPOXIDE IN THE PRESENCE OF NOVEL COMPLEX<br/>[FR] PROCÉDÉ DE PRÉPARATION DE POLY(CARBONATE D'ALKYLÈNE) PAR COPOLYMÉRISATION DE DIOXYDE DE CARBONE ET D'ÉPOXYDE EN PRÉSENCE D'UN NOUVEAU COMPLEXE
  申请人：SK INNOVATION CO LTD

  公开号：WO2014148825A1

  公开（公告）日：2014-09-25

  Provided is a method of preparing poly(alkylene carbonate) using a molecular weight regulator in a process of preparing a copolymer of carbon dioxide/epoxide using a novel complex synthesized from salen-type ligand including a quaternary ammonium salt as a catalyst. According to the present invention, even though the molecular weight regulator is used, an activity of the catalyst may be stably maintained, whereby the low molecular weight of poly(alkylene carbonate) having a desirable level may be effectively provided. In addition, it is expected that since the novel complex as the catalyst of the present invention has a simple structure as compared to the existing copolymerization catalyst, due to the economical preparation cost thereof, the novel complex may be effectively applied to a large-scale commercial process.

  提供了一种使用分子量调节剂制备聚（烷基碳酸酯）的方法，该方法是在制备二氧化碳/环氧丙烷共聚物过程中使用一种新型复合物合成的咖啡碱盐类催化剂，其中该复合物包括一种四元铵盐作为催化剂的萨伦型配体。根据本发明，即使使用了分子量调节剂，催化剂的活性也可以稳定地保持，从而可以有效地提供具有理想水平的低分子量聚（烷基碳酸酯）。此外，由于本发明的催化剂新型复合物与现有的共聚催化剂相比具有简单的结构，因此具有经济成本，预计该新型复合物可以有效应用于大规模商业过程。
• [EN] LIPID COMPOUNDS AND LIPID NANOPARTICLE COMPOSITIONS<br/>[FR] COMPOSÉS LIPIDIQUES ET COMPOSITIONS DE NANOPARTICULES LIPIDIQUES
  申请人：SUZHOU ABOGEN BIOSCIENCES CO LTD

  公开号：WO2022002040A1

  公开（公告）日：2022-01-06

  Provided herein are lipid compounds that can be used in combination with other lipid components, such as neutral lipids, cholesterol and polymer conjugated lipids, to form lipid nanoparticles for delivery of therapeutic agents (e.g., nucleic acid molecules) for therapeutic or prophylactic purposes, including vaccination. Also provided herein are lipid nanoparticle compositions comprising said lipids.

  本文提供的是脂质化合物，可以与其他脂质成分（如中性脂质、胆固醇和聚合物结合的脂质）结合使用，形成脂质纳米颗粒，用于传递治疗剂（如核酸分子）以进行治疗或预防目的，包括疫苗接种。本文还提供了包含上述脂质的脂质纳米颗粒组合物。
• BIOCIDE FREE ASSOCIATIVE THICKENER
  申请人：Rohm and Haas Company

  公开号：EP3766346A1

  公开（公告）日：2021-01-20

  The present invention relates to a composition comprising an aqueous solution of a) a hydrophobically modified alkylene oxide polymer comprising a hydrophobic portion functionalized with a protonated secondary or tertiary amine or a quaternary ammonium salt and b) an acid and a salt thereof, which acid is phosphoric acid, nitrilotris(methylene)triphosphonic acid, hydrochloric acid, or sulfuric acid. The composition of the present invention is useful for the preparation of an associative thickener that can be stored for long periods, in the absence of ancillary biocides, without spoilage from biodeteriogenic attack.

  本发明涉及一种组合物，该组合物包含 a) 疏水性改性环氧亚烷基聚合物的水溶液，该聚合物包含用质子化仲胺或叔胺或季铵盐官能化的疏水部分；b) 酸及其盐，该酸为磷酸、亚硝基三(亚甲基)三膦酸、盐酸或硫酸。本发明的组合物可用于制备一种可长期储存的缔合增稠剂，在没有辅助杀菌剂的情况下，不会因生物杀菌作用而变质。
• Method of preparing poly(alkylene carbonate) via copolymerization of carbon dioxide/epoxide in the presence of novel complex
  申请人：SK Innovation Co., Ltd.

  公开号：US10723837B2

  公开（公告）日：2020-07-28

  Provided is a method of preparing poly(alkylene carbonate) using a molecular weight regulator in a process of preparing a copolymer of carbon dioxide/epoxide using a novel complex synthesized from salen-type ligand including a quaternary ammonium salt as a catalyst. According to the present invention, even though the molecular weight regulator is used, an activity of the catalyst may be stably maintained, whereby the low molecular weight of poly(alkylene carbonate) having a desirable level may be effectively provided. In addition, it is expected that since the novel complex as the catalyst of the present invention has a simple structure as compared to the existing copolymerization catalyst, due to the economical preparation cost thereof, the novel complex may be effectively applied to a large-scale commercial process.

  本发明提供了一种在制备二氧化碳/环氧化物共聚物的过程中使用分子量调节剂制备聚（碳酸亚烷基酯）的方法，该方法使用了一种由包括季铵盐的沙伦型配体合成的新型配合物作为催化剂。根据本发明，即使使用分子量调节剂，催化剂的活性仍可稳定保持，从而可有效提供具有理想水平的低分子量聚（碳酸亚烷基酯）。此外，由于作为本发明催化剂的新型络合物与现有的共聚催化剂相比结构简单，制备成本低廉，因此预计新型络合物可有效地应用于大规模商业工艺中。