N-((1R,2R)-2-aminocyclohexyl)-2,3-dichlorobenzenesulfonamide | 1621513-78-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-((1R,2R)-2-aminocyclohexyl)-2,3-dichlorobenzenesulfonamide
• 英文别名: N-[(1R,2R)-2-aminocyclohexyl]-2,3-dichlorobenzenesulfonamide
• CAS: 1621513-78-7
• 化学式: C₁₂H₁₆Cl₂N₂O₂S
• 分子量: 323.243
• InChiKey: CQHZLXPNRDDCBX-NXEZZACHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  80.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,3-二氯苯磺酰氯 、 (1R,2R)-(+)-1,2-环己二胺 L-酒石酸盐 在 三乙胺 、 sodium hydroxide 作用下， 以 二氯甲烷 、 水 为溶剂， 以44%的产率得到N-((1R,2R)-2-aminocyclohexyl)-2,3-dichlorobenzenesulfonamide
  参考文献：
  名称：

  Oxygen–chlorine interactions in the transition state of asymmetric Michael additions of carbonyl compounds to β-nitrostyrene

  摘要：

  An oxygen-chlorine interaction is reported in the transition state of the Michael addition of acetone to nitrostyrene catalyzed by enantioenriched monosulfonamides. The interaction between the oxygen from the nitro group and the chlorine at the ortho-position of the sulfonamide moiety is supported by theoretical calculations. Asymmetric Michael addition products catalyzed by monosulfonamides were obtained in moderate yields and enantioselectivities. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2014.05.002

文献信息

• Oxygen–chlorine interactions in the transition state of asymmetric Michael additions of carbonyl compounds to β-nitrostyrene
  作者：José A. Romero、Angélica Navarrate、Felipe A. Servín、Domingo Madrigal、Andrew L. Cooksy、Gerardo Aguirre、Daniel Chávez、Ratnasamy Somanathan

  DOI：10.1016/j.tetasy.2014.05.002

  日期：2014.7

  An oxygen-chlorine interaction is reported in the transition state of the Michael addition of acetone to nitrostyrene catalyzed by enantioenriched monosulfonamides. The interaction between the oxygen from the nitro group and the chlorine at the ortho-position of the sulfonamide moiety is supported by theoretical calculations. Asymmetric Michael addition products catalyzed by monosulfonamides were obtained in moderate yields and enantioselectivities. (C) 2014 Elsevier Ltd. All rights reserved.