2H-indazol-2-amine | 33334-11-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 2H-indazol-2-amine
• 英文别名: 2-amino-2H-indazole；N-Amino-2H-indazole；2-Aminoindazole；indazol-2-ylamine；2-Aminoindazol；indazol-2-amine
• CAS: 33334-11-1
• 化学式: C₇H₇N₃
• 分子量: 133.153
• InChiKey: CCBYKULDFQDEAC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2H-indazol-2-amine 在 sodium tetrahydroborate 、 溶剂黄146 作用下， 以 异丙醇 为溶剂， 反应 25.0h， 生成 2-(benzylamino)indazole
  参考文献：
  名称：

  某些（N-苄基-N-亚硝基氨基）唑的构象移动性的合成与研究

  摘要：

  DOI：

  10.1007/s10593-005-0152-1
• 作为产物：
  描述：

  2-[(2-Azidophenyl)methylidene]hydrazine-1-carboxamide 以 二苯醚 为溶剂， 反应 0.08h， 以25%的产率得到2H-indazol-2-amine
  参考文献：
  名称：

  Ardakani, Manouchehr Azadi; Smalley, Robert K.; Smith, Richard H., Journal of the Chemical Society. Perkin transactions I, 1983, # 10, p. 2501 - 2506

  摘要：

  DOI：

文献信息

• [EN] COMPOUNDS, COMPOSITIONS AND METHODS FOR CONTROLLING BIOFILMS<br/>[FR] COMPOSÉS, COMPOSITIONS ET PROCÉDÉS DE LUTTE CONTRE LES BIOFILMS
  申请人：UNIV LEUVEN KATH

  公开号：WO2017070755A1

  公开（公告）日：2017-05-04

  The present invention relates to substituted 5-aryl-2-aminoimidiazole compounds being active against microbial biofilm formation. The invention also relates to compositions comprising a microbial biofilm inhibiting amount of said substituted 5-aryl-2-aminoimidiazole compounds in combination with excipients. Methods for inhibiting or controlling microbial biofilm formation in a plant, a body part of a human or an animal, or a surface with which a human or an animal may come into contact are also disclosed.

  本发明涉及对微生物生物膜形成具有活性的取代5-芳基-2-氨基咪唑化合物。该发明还涉及包含所述取代5-芳基-2-氨基咪唑化合物的微生物生物膜抑制量与赋形剂结合的组合物。还公开了在植物、人类或动物的身体部位，或人类或动物可能接触的表面上抑制或控制微生物生物膜形成的方法。
• [EN] HETEROTRICYCLIC COMPOUNDS AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS<br/>[FR] COMPOSÉS HÉTÉROTRICYCLIQUES EN TANT QUE MODULATEURS ALLOSTÉRIQUES POSITIFS DES RÉCEPTEURS GLUTAMATERGIQUES MÉTABOTROPES
  申请人：ADDEX PHARMACEUTICALS SA

  公开号：WO2010079238A1

  公开（公告）日：2010-07-15

  The present invention relates to novel compounds of Formula (I), wherein wherein X1, X2, Y, Z1, Z2, Z3, M and (A)m are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate receptors - subtype 4 ("mGluR4") which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mGluR4 receptors. The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR4 is involved.

  本发明涉及式(I)的新化合物，其中X1、X2、Y、Z1、Z2、Z3、M和(A)m的定义如式(I)中所述；该发明化合物是代谢型谷氨酸受体-亚型4（"mGluR4"）的调节剂，对于治疗或预防中枢神经系统疾病以及其他受mGluR4受体调节的疾病具有用处。该发明还涉及制药组合物以及利用这些化合物制造药物的用途，以及利用这些化合物预防和治疗涉及mGluR4的疾病的用途。
• [EN] INHIBITORS OF RHO ASSOCIATED PROTEIN KINASES (ROCK) AND METHODS OF USE<br/>[FR] INHIBITEURS DE PROTÉINES KINASES ASSOCIÉES À RHO (ROCK) ET PROCÉDÉS D'UTILISATION
  申请人：H LEE MOFFITT CANCER CT & RES

  公开号：WO2013112722A1

  公开（公告）日：2013-08-01

  Compounds and compositions having activity as inhibitors of Rho-associated proteinkinases (ROCKs), and methods of making and using the subject compounds are disclosed.

  具有抑制Rho相关蛋白激酶（ROCKs）活性的化合物和组合物，以及制备和使用这些化合物的方法被披露。
• [EN] 2-AMINOIMIDAZOLE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE<br/>[FR] INHIBITEURS DE LA 2-AMINOIMIDAZOLE BÊTA-SECRÉTASE UTILES POUR LE TRAITEMENT DE LA MALADIE D'ALZHEIMER
  申请人：MERCK & CO INC

  公开号：WO2009108550A1

  公开（公告）日：2009-09-03

  The present invention is directed to 2-aminoimidazole compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

  本发明涉及式(I)的2-氨基咪唑化合物，它们是β-分泌酶酶的抑制剂，可用于治疗涉及β-分泌酶酶的疾病，如阿尔茨海默病。该发明还涉及包含这些化合物的药物组合物，以及在治疗涉及β-分泌酶酶的疾病中使用这些化合物和组合物。
• Novel 4-cyano, 4-amino, and 4-aminomethyl derivatives of pyrazolo[1,5-a]pyridines, pyrazolo[1,5-c]pyrimidines and 2h-indazole compounds and 5-cyano, 5-amino, and 5-aminomethyl derivatives of imidazo[1,2-a]pyridines, and imidazo[1,5-a]pyrazines as cyclin dependent kinase inhibitors
  申请人：Mallams K. Alan

  公开号：US20070066621A1

  公开（公告）日：2007-03-22

  In its many embodiments, the present invention provides a novel class of 4-cyano, 4-amino, and 4-aminomethyl derivatives of pyrazolo[1,5-a]pyridine, pyrazolo[1,5-c]pyrimidine, and 2H-Indazole compounds and 5-cyano, 5-amino, and 5-aminomethyl derivatives of imidazo[1,2-a]pyridine and imidazo[1,5-a]pyrazine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

  在其多种形式中，本发明提供了一类新颖的吡唑并[1,5-a]吡啶，吡唑并[1,5-c]嘧啶和2H-吲唑化合物的4-氰基，4-氨基和4-氨基甲基衍生物，以及咪唑并[1,2-a]吡啶和咪唑并[1,5-a]吡嗪化合物的5-氰基，5-氨基和5-氨基甲基衍生物作为细胞周期依赖性激酶的抑制剂，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备包含一种或多种此类化合物的药物制剂的方法，以及使用此类化合物或药物组合物治疗、预防、抑制或改善与CDKs相关的一种或多种疾病的方法。

表征谱图