1,4-dimethyl-5-oxo-pyrrolidine-3-carboxylic acid ethyl ester | 60298-19-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1,4-dimethyl-5-oxo-pyrrolidine-3-carboxylic acid ethyl ester
• 英文别名: 3-Pyrrolidinecarboxylic acid, 1,4-dimethyl-5-oxo-, ethyl ester；ethyl 1,4-dimethyl-5-oxopyrrolidine-3-carboxylate
• CAS: 60298-19-3
• 化学式: C₉H₁₅NO₃
• 分子量: 185.223
• InChiKey: OUVSFSLXBLPDNG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,4-dimethyl-5-oxo-pyrrolidine-3-carboxylic acid ethyl ester 、 phenylmagnesium bromide 以53%的产率得到
  参考文献：
  名称：

  OHKI S.; OZAWA N.; JABE J.; MATZUDA H., CHEM. AND PHARM. BULL. , 1976, 24, NO 6, 1362-1370

  摘要：

  DOI：
• 作为产物：
  描述：

  3-Pyrrolidinecarboxylic acid, 4-methyl-5-oxo-, ethyl ester 以45%的产率得到
  参考文献：
  名称：

  OHKI S.; OZAWA N.; JABE J.; MATZUDA H., CHEM. AND PHARM. BULL. , 1976, 24, NO 6, 1362-1370

  摘要：

  DOI：

文献信息

• COSMETIC AND/OR DERMATOLOGICAL COMPOSITION CONTAINING A MEROCYANINE DERIVATIVE COMPRISING SPECIFIC POLAR GROUPS CONSISTING OF HYDROXYL- AND ETHER-FUNCTIONALITIES
  申请人：Richard Herve

  公开号：US20140294743A1

  公开（公告）日：2014-10-02

  The present invention relates to a cosmetic and/or dermatological composition comprising in a physiologically acceptable medium at least one merocyanine derivative of formula (1) or (2) and/or its E,E-, E,Z- or Z,Z-geometrical isomer forms: comprising specific polar groups consisting of hydroxyl- and ether-functionalities. Another object of the present invention relates to a cosmetic process for controlling and/or improving the darkening of the skin under exposure to UV radiation and the homogeneity of the colour of the complexion which comprises the application onto the skin of a cosmetic composition as above defined. Another object of the present invention relates to a cosmetic process for protecting the keratinic materials and particularly the skin against photo-ageing which comprises the application onto the keratinic material of a cosmetic composition as above defined.

  本发明涉及一种化妆品和/或皮肤科学组合物，其在生理上可接受的介质中包含至少一种公式（1）或（2）的merocyanine衍生物及/或其E，E-，E，Z-或Z，Z-几何异构体形式：包括由羟基和醚功能团组成的特定极性基团。本发明的另一个目的涉及一种化妆过程，用于控制和/或改善皮肤在紫外线照射下的变黑和肤色均匀性，包括在皮肤上涂抹上述定义的化妆品组合物。本发明的另一个目的涉及一种化妆过程，用于保护角质素材料，特别是皮肤免受光老化的影响，包括在角质素材料上涂抹上述定义的化妆品组合物。
• [EN] COSMETIC AND/OR DERMATOLOGICAL COMPOSITION CONTAINING A MEROCYANINE DERIVATIVE COMPRISING SPECIFIC POLAR GROUPS CONSISTING OF HYDROXYL- AND ETHER-FUNCTIONALITIES<br/>[FR] COMPOSITION COSMÉTIQUE ET/OU DERMATOLOGIQUE CONTENANT UN DÉRIVÉ DE MÉROCYANINE QUI COMPREND DES GROUPES POLAIRES SPÉCIFIQUES CONSTITUÉS DE FONCTIONNALITÉS HYDROXYLE ET ÉTHER
  申请人：OREAL

  公开号：WO2013010590A1

  公开（公告）日：2013-01-24

  A cosmetic and/or dermatologigal composition comprising in a physiologically acceptable medium at least one merocyanine derivative of formula (1) or (2) and/or its Ε,Ε-, Ε,Ζ- or Z, Z - geometrical isomer forms: comprising specific polar groups consisting of hydroxyl - and ether- functionalities. A cosmetic process for controlling and/or improving the darkening of the skin under exposure to UV radiation and the homogeneity of the colour of the complexion which comprises the application onto the skin of a cosmetic composition as above defined. A cosmetic process for protecting the keratinic materials and particularly the skin against photo-ageing which comprises the application onto the keratinic material of a cosmetic composition as above defined. Use of merocyanines for protecting bodycare products from photolytic and oxidative degradation.

  一种化妆品和/或皮肤科组合物，包括生理可接受介质中的至少一种公式（1）或（2）的并环氰染料衍生物及/或其Ε，Ε-，Ε，Ζ-或Z，Z-几何异构体形式：包括由羟基和醚基构成的特定极性基团。一种化妆品过程，用于控制和/或改善皮肤在紫外线照射下的黑化和肤色的均匀性，其中包括将上述定义的化妆品组合物涂抹于皮肤上。一种化妆品过程，用于保护角蛋白材料，特别是皮肤免受光老化的影响，其中包括将上述定义的化妆品组合物涂抹于角蛋白材料上。使用并环氰染料保护身体护理产品免受光解和氧化降解的影响。
• [EN] COSMETIC COMPOSITION COMPRISING A POLYMER AND A 4-CARBOXY-2-PYRROLIDINONE DERIVATIVE, COSMETIC TREATMENT PROCESS AND COMPOUND<br/>[FR] COMPOSITION COSMÉTIQUE COMPRENANT UN POLYMÈRE ET UN DÉRIVÉ DE 4-CARBOXY-2-PYRROLIDINONE, COMPOSÉ ET PROCÉDÉ DE TRAITEMENT COSMÉTIQUE
  申请人：OREAL

  公开号：WO2011154508A1

  公开（公告）日：2011-12-15

  The present invention relates to a cosmetic composition comprising, in a cosmetically acceptable medium, from 2% to 99% by weight, relative to the total weight of the composition, of a polymer or of a blend of polymers, and 0.5% to 40% by weight of compound of formula (I), alone or as a mixture, and/or a salt thereof: in which: R1 denotes H or a linear C1-C20 or branched en C3-C20 alkyl radical; R2 denotes a linear C1-C20 or branched C3-C20 alkyl radical which can contain a C5-C6 ring; an optionally substituted C5-C6 cycloalkyl radical; the phenyl radical, the benzyl radical or the phenethyl radical; R3 and R4 denote H or a linear C1-C12 or branched C3-C12 alkyl radical; it being understood that, when R1 = H, the compounds may be in their free acid form or in the form of their cosmetically acceptable salts. The invention also relates to a cosmetic treatment process using said composition, and also to a specific compound.
• [EN] COSMETIC COMPOSITION INCLUDING A FUNCTIONALISED OIL AND A SOLVENT, AND COSMETIC TREATMENT METHOD<br/>[FR] Composition cosmétique comprenant une huile fonctionnalisée et un solvant et procédé de traitement cosmétique
  申请人：OREAL

  公开号：WO2013001250A2

  公开（公告）日：2013-01-03

  La présente invention concerne une composition cosmétique comprenant un mélange de - au moins une huile fonctionnalisée uréïdopyrimidone, portant un groupe de jonction comprenant au moins un motif de formule (I) ou (II) : - au moins un solvant de formule (I) : dans laquelle : - R'1 désigne H ou un radical alkyle linéaire en C1-C20 ou ramifié en C3-C20; - R'2 désigne un radical alkyle linéaire en C1-C20 ou ramifié en C3-C20 pouvant contenir un cycle en C5-C6; un radical cycloalkyle en C5-C6 éventuellement substitué par un ou deux radicaux méthyle; le radical phényle, le radical benzyle ou le radical phénétyle; - R'3 et R'4 désignent H ou un radical alkyle linéaire en C1-C12 ou ramifié en C3-C12. L'invention concerne également un procédé de traitement cosmétique utilisant la¬ dite composition.
• [EN] COSMETIC AND/OR DERMATOLOGICAL COMPOSITION CONTAINING A MEROCYANINE DERIVATIVE COMPRISING SPECIFIC POLAR GROUPS CONSISTING OF HYDROXYL- AND ETHER-FUNCTIONALITIES<br/>[FR] COMPOSITION COSMÉTIQUE ET/OU DERMATOLOGIQUE CONTENANT UN DÉRIVÉ DE MÉROCYANINE COMPORTANT DES GROUPES POLAIRES SPÉCIFIQUES CONSTITUÉS DE FONCTIONNALITÉS HYDROXYLE ET ÉTHER
  申请人：OREAL

  公开号：WO2013011094A2

  公开（公告）日：2013-01-24

  The present invention relates to a cosmetic and/or dermatologigal composition comprising in a physiologically acceptable medium at least one merocyanine derivative of formula (1) or (2) and/or its E,E-, E,Z- or Z,Z-geometrical isomer forms: comprising specific polar groups consisting of hydroxyl- and ether-functionalities. Another object of the present invention relates to a cosmetic process for controlling and/or improving the darkening of the skin under exposure to UV radiation and the homogeneity of the colour of the complexion which comprises the application onto the skin of a cosmetic composition as above defined. Another object of the present invention relates to a cosmetic process for protecting the keratinic materials and particularly the skin against photo-ageing which comprises the application onto the keratinic material of a cosmetic composition as above defined.