diethyl (5-oxo-4,5-dihydroindeno[2,3-b][1,4]oxazin-3-yl)phosphonate | 1148119-33-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: diethyl (5-oxo-4,5-dihydroindeno[2,3-b][1,4]oxazin-3-yl)phosphonate
• 英文别名: Diethyl (5-oxo-4,5-dihydroindeno[1,2-b][1,4]oxazin-3-yl)phosphonate；3-diethoxyphosphoryl-4H-indeno[1,2-b][1,4]oxazin-5-one
• CAS: 1148119-33-8
• 化学式: C₁₅H₁₆NO₅P
• 分子量: 321.269
• InChiKey: YGIHTWKCPBJHFB-UHFFFAOYSA-N

物化性质

• 沸点：
  462.1±45.0 °C(predicted)
• 密度：
  1.36±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  73.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1H-茚-1,2,3-三酮2-肟 、 乙烯基磷酸二乙酯 在 sodium ethanolate 作用下， 反应 12.0h， 以46%的产率得到diethyl (5-oxo-4,5-dihydroindeno[2,3-b][1,4]oxazin-3-yl)phosphonate
  参考文献：
  名称：

  An efficient method for the synthesis of spiro and fused N-heterocyclic phosphor esters. Reactions of triketoindan-2-oxime with α-phosphonyl carbanions

  摘要：

  Treatment of triketoindan-2-oxime with alpha-phosphonyl carbanions in sodium ethanolate solution at reflux temperature led to a number of the corresponding substituted spiroisooxazole-, fused 1,3-oxazole, and 1,4-oxazine phosphor esters in moderate to high yields. Mechanisms for the formation of five- and six-membered rings are provided. A comparison of Wittig-Horner and Wittig reagent counterparts in reactions with the oxime is discussed. The various biological properties of selected examples of the synthesized products were studied.

  DOI：

  10.1007/s00706-007-0806-z

文献信息

• An efficient method for the synthesis of spiro and fused N-heterocyclic phosphor esters. Reactions of triketoindan-2-oxime with α-phosphonyl carbanions
  作者：Wafaa M. Abdou、Ashraf A. Sediek、Maha D. Khidre

  DOI：10.1007/s00706-007-0806-z

  日期：2008.6

  Treatment of triketoindan-2-oxime with alpha-phosphonyl carbanions in sodium ethanolate solution at reflux temperature led to a number of the corresponding substituted spiroisooxazole-, fused 1,3-oxazole, and 1,4-oxazine phosphor esters in moderate to high yields. Mechanisms for the formation of five- and six-membered rings are provided. A comparison of Wittig-Horner and Wittig reagent counterparts in reactions with the oxime is discussed. The various biological properties of selected examples of the synthesized products were studied.