(RuCl2(η6-C6Me6))2 | 847615-12-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (RuCl2(η6-C6Me6))2
• 英文别名: [(η6-hexamethylbenzene)RuCl2]2；1,2,3,4,5,6-hexamethylbenzene;ruthenium(2+);tetrachloride
• CAS: 847615-12-7
• 化学式: C₂₄H₃₆Cl₄Ru₂
• 分子量: 668.502
• InChiKey: GVCIEWAYDUQTTQ-UHFFFAOYSA-J

计算性质

• 辛醇/水分配系数(LogP)：
  9.83
• 重原子数：
  30
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  (RuCl2(η6-C6Me6))2 、 哌嗪-1,4-二甲腈 以 二氯甲烷 为溶剂， 以55%的产率得到dichlororuthenium;1,2,3,4,5,6-hexamethylbenzene;piperazine-1,4-dicarbonitrile
  参考文献：
  名称：

  Gupta; Sahay; Pandey, Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical, 1999, vol. 38, # 2, p. 190 - 193

  摘要：

  DOI：

文献信息

• Bis(diphenylphosphino)methane and its sulphide or selenide derivatives as ligands in ruthenium(II) and rhodium(III) complexes: Crystal structure of [(η6C6Me6)Ru{η3(SPPh2)2CH}]ClO4
  作者：Mauricio Valderrama、Raul Contreras、Manuel Bascuñan、Sergio Alegria、Daphne Boys

  DOI：10.1016/0277-5387(94)00494-y

  日期：1995.8

  thallium pyrazolate in dichloromethane solution by deprotonation of the coordinated bidentate ligand giving the complex [(η6C6Me6)Ruη3(SPPh2)2CH-C,S,S′}]ClO4. The structure of this compl has been determined by single crystal X-ray diffraction methods. The complex contains a tridentate C,S,S′-bonded ligand occupying three coordination positions of a distorted octahedral ruthenium centre, with an η6C6Me6

  配合物的反应[（η 6 ç 6我6）的RuCl 2 ] 2和[（η 5 ç 5我5）的RhCl 2 ] 2与配体L博士2 PCH 2 PPH 2（DPPM）或PH 2 PCH 2 P （SE）PH 2在导致中性络合物与通式[（环）的MC1苯溶液2（η 1L）]。已经研究了dppm的未配位的P原子的反应性。当反应在甲醇溶液中进行时，获得阳离子配体以其双齿形式起作用的阳离子配合物。使用丙酮作为溶剂在高氯酸钠的存在下，得到[（环）的MC1（制备类似的阳离子高氯酸络合物η 2 L）CLO 4，其中L博士2 PCH 2 PPH 2中，Ph 2 PCH 2 P（硒）PH 2或Ph 2 P（S）CH 2 P（S）Ph 2。的配合物[（η 6 ç 6我6）的RuCl η 2（SPPh）2 CH 2 -S，S'}] CLO 4与氢化钠在四氢呋喃或通过协调二齿的脱质子化的二氯甲烷溶液铊吡配体反应得到的配合物[（η
• Mono- and bis-(acetylacetonato) complexes of arene-ruthenium(II) and arene-osmium(II): variation of the binding mode of η¹-acetylacetonate with the nature of the arene
  作者：Martin A Bennett、Thomas R Mitchell、Mark R Stevens、Anthony C Willis

  DOI：10.1139/v01-076

  日期：2001.5.1

  The mono(acetylacetonato) complexes [MCl(O,O'-acac)(η6-arene)] (M = Ru, Os, arene = C6H6, 1,3,5-C6H3Me3, C6Me6; M = Os, arene = 1,2-C6H4Me2, 1,2,3-C6H3Me3), which are formed from [MCl2(η6-arene)]2 and thallium or sodium acetylacetonate, react with thallium acetylacetonate to give bis(acetylacetonato) complexes [M(O,O'-acac)(η1-acac)(η6-arene)]. The η1-acac ligand is bound through the gamma-carbon atom

  单（乙酰丙酮）配合物 [MCl(O,O'-acac)(η6-arene)] (M = Ru, Os, arene = C6H6, 1,3,5-C6H3Me3, C6Me6; M = Os, arene = 1 ,2-C6H4Me2, 1,2,3-C6H3Me3) 由 [MCl2(η6-arene)]2 和铊或乙酰丙酮钠形成，与乙酰丙酮铊反应生成双（乙酰丙酮）络合物 [M(O,O) '-acac)(η1-acac)(η6-芳烃)]。对于 M = Ru、Os、芳烃 = C6H6，η1-acac 配体通过 γ-碳原子结合；M = Os, 芳烃 = 1,2-C6H4Me2, 1,2,3-C6H3Me3 并通过酮氧原子为 M = Ru, Os, 芳烃 = 1,3,5-C6H3Me3, C6Me6，差异归因于立体效应和电子效应的结合。阳离子钌 (II) 衍生物 [Ru(L)(O,O'-acac)(η6-芳烃]+
• Synthesis and investigation of antiproliferative activity of Ru-NHC complexes against C6 and HeLa cancer cells
  作者：RAMAZAN PAŞAHAN、MİTAT AKKOÇ、ŞEYMA YAŞAR、TUĞBA KUL KÖPRÜLÜ、ŞABAN TEKİN、SEDAT YAŞAR、İSMAİL ÖZDEMİR

  DOI：10.55730/1300-0527.3418

  日期：——

  The 2-methylpyridine, 2-diethylaminoethyl, and isopentyl linked a series of symmetric and unsymmetric benzimidazolium salts 2a-e were prepared and used in the synthesis of silver-N-heterocyclic carbene (NHC) complexes (3a-e). The Ru(II)-NHC complexes (4a-h) were synthesized via transmetalation reaction from 3a-e. 4a-h complexes were converted to Ru(II)-NHC.HCl complexes (5ah) by HCl solution of diethyl ether and characterized by different spectroscopic techniques such as 1H and 13C NMR, LC/MS-Q-TOF, FT-IR, elemental analysis, and melting point detection. We examined the effect of the structural difference of complexes on anticancer activity via different arenes and metal centers. Antiproliferative activity of 5a-h and 3a was tested against human cervix adenocarcinoma (HeLa) and rat glioblastoma (C6) cell lines by ELISA assay. The IC50 value of 5b, 5c and 5e complexes exhibited good cytotoxic activity than cisplatin on C6 (14.2 ± 0.5 mM; 16.2 ± 0.4 mM; 24.2 ± 0.7 mM, respectively) and HeLa (11.1 ± 0.5 mM; 13.7 ± 0.3 mM; 22.8 ± 0.8 mM, respectively) cell lines.

  2-甲基吡啶、2-二乙基氨基乙基和异戊基连接了一系列对称和非对称的苯并咪唑鎓盐2a-e，用于合成银-N-杂环卡宾（NHC）络合物（3a-e）。通过3a-e的转金属反应，合成了Ru（II）-NHC络合物（4a-h）。4a-h络合物通过二乙醚的HCl溶液转化为Ru（II）-NHC.HCl络合物（5ah），并通过1H和13C NMR、LC/MS-Q-TOF、FT-IR、元素分析和熔点检测等不同的光谱技术进行表征。我们研究了不同芳烃和金属中心的络合物结构差异对抗癌活性的影响。通过ELISA测定，对5a-h和3a的抗增殖活性进行了测试，分别针对人宫颈癌腺癌（HeLa）和大
• Pathak, Satyajit; Gupta; Sahay, Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical, 1998, vol. 37, # 2, p. 165 - 168
  作者：Pathak, Satyajit、Gupta、Sahay、Pandey

  DOI：——

  日期：——
• Pandey; Sahay; Agarwala, Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical, 1996, vol. 35, # 5, p. 434 - 437
  作者：Pandey、Sahay、Agarwala

  DOI：——

  日期：——