2-[(3-Nitrophenoxy)methyl]-4,5-dihydro-1,3-oxazole | 1063738-04-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(3-Nitrophenoxy)methyl]-4,5-dihydro-1,3-oxazole
• CAS: 1063738-04-4
• 化学式: C₁₀H₁₀N₂O₄
• 分子量: 222.2
• InChiKey: YCXGCVUEXSXBGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  76.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-硝基苯氧乙酸 、 C.I.酸性橙108 生成 2-[(3-Nitrophenoxy)methyl]-4,5-dihydro-1,3-oxazole
  参考文献：
  名称：

  Synthesis and anti-inflammatory activity of 2-aryloxy methyl oxazolines

  摘要：

  A series of potential biologically active 2-aryloxy methyl oxazolines 3a-n have been synthesized from substituted hydroxybenzenes 1a-n with good chemical yield. The compounds 3a-n were screened for their anti-inflammatory, ulcerogenic, cyclooxygenase activities and also for their acute toxicity. The potency of the compounds was compared with that of the standard drugs, aspirin and phenyl butazone. The outcome indicates that compounds 3b (48.2%), 3h (48.5%) and 31 (46.5%) offered significant anti-inflammatory activity with low ulcerogenic activity than the standard drugs. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.07.029

文献信息

• Synthesis and anti-inflammatory activity of 2-aryloxy methyl oxazolines
  作者：Shaukath Ara Khanum、Noor Fatima Khanum、M. Shashikanth

  DOI：10.1016/j.bmcl.2008.07.029

  日期：2008.8

  A series of potential biologically active 2-aryloxy methyl oxazolines 3a-n have been synthesized from substituted hydroxybenzenes 1a-n with good chemical yield. The compounds 3a-n were screened for their anti-inflammatory, ulcerogenic, cyclooxygenase activities and also for their acute toxicity. The potency of the compounds was compared with that of the standard drugs, aspirin and phenyl butazone. The outcome indicates that compounds 3b (48.2%), 3h (48.5%) and 31 (46.5%) offered significant anti-inflammatory activity with low ulcerogenic activity than the standard drugs. (C) 2008 Elsevier Ltd. All rights reserved.