7-cyano-3,4-dihydro-1H-isoquinoline-2-sulfonamide | 916210-04-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 7-cyano-3,4-dihydro-1H-isoquinoline-2-sulfonamide
• CAS: 916210-04-3
• 化学式: C₁₀H₁₁N₃O₂S
• 分子量: 237.282
• InChiKey: VCXANGAKTQTATH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  95.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  7-cyano-3,4-dihydro-1H-isoquinoline-2-sulfonamide 、 二碳酸二叔丁酯 在 nickel dichloride sodium tetrahydroborate 、 二乙烯三胺 作用下， 以 甲醇 为溶剂， 以46%的产率得到tert-butyl N-[(2-sulfamoyl-3,4-dihydro-1H-isoquinolin-7-yl)methyl]carbamate
  参考文献：
  名称：

  WO2006/128184

  摘要：

  公开号：
• 作为产物：
  描述：

  1,2,3,4-四氢异喹啉-7-甲腈 在 磺酰胺 作用下， 以 乙二醇二甲醚 为溶剂， 以99%的产率得到7-cyano-3,4-dihydro-1H-isoquinoline-2-sulfonamide
  参考文献：
  名称：

  WO2006/128184

  摘要：

  公开号：

文献信息

• Heterobicyclic metalloprotease inhibitors
  申请人：Steeneck Christoph

  公开号：US20070155738A1

  公开（公告）日：2007-07-05

  The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.
• Heterobicyclic Metalloprotease Inhibitors
  申请人：STEENECK Christoph

  公开号：US20090312312A1

  公开（公告）日：2009-12-17

  The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.
• HETEROBICYCLIC METALLOPROTEASE INHIBITORS
  申请人：Steeneck Christoph

  公开号：US20120015920A1

  公开（公告）日：2012-01-19

  The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.
• US7795245B2
  申请人：——

  公开号：US7795245B2

  公开（公告）日：2010-09-14
• US8835441B2
  申请人：——

  公开号：US8835441B2

  公开（公告）日：2014-09-16