N¹-(p-Chlorphenyl)-N⁵-methylbiguanide | 60221-92-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N¹-(p-Chlorphenyl)-N⁵-methylbiguanide
• 英文别名: 1-(4-chloro-phenyl)-5-methyl-biguanide；1-(4-Chlor-phenyl)-5-methyl-biguanid；N¹-p-Chlorphenyl-N⁵-methylbiguanid；1-[Amino-(4-chloroanilino)methylidene]-2-methylguanidine
• CAS: 60221-92-3
• 化学式: C₉H₁₂ClN₅
• 分子量: 225.681
• InChiKey: FRANGYONAXSDBQ-UHFFFAOYSA-N

物化性质

• 熔点：
  85-86 °C
• 沸点：
  298.6±42.0 °C(Predicted)
• 密度：
  1.36±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  88.8
• 氢给体数：
  3
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-(4-chloro-phenyl)-N-cyano-triazene-1-carboxamidine 在 盐酸 、 乙醇 、 1-乙氧基乙醇 、 copper(II) sulfate 作用下， 生成 N¹-(p-Chlorphenyl)-N⁵-methylbiguanide
  参考文献：
  名称：

  149.合成抗疟药。第十部分。一些芳基-双胍（“-双胍”）衍生物

  摘要：

  DOI：

  10.1039/jr9460000729

文献信息

• On the anomalous sorption behaviour of chlorhexidine with poly(2-hydroxyethyl methacrylate)
  作者：B S Plaut、B J Meakin、D J G Davies

  DOI：10.1111/j.2042-7158.1980.tb12989.x

  日期：2011.4.12

  General observations of solute: plastic interactions would suggest that the sorption of the cationic preservative, chlorhexidine, with poly (2-hydroxyethyl methacrylate) (PHEMA) is not only unexpected but also atypical in its properties. The polymer and preservative were investigated independently and the sorption of PHEMA with simple solutes, namely benzoic acid, benzocaine and aniline found to exhibit conventional properties. The single exception was the uptake of small amounts of benzocaine and aniline cations at acidic pH's. In order to elucidate the sorption characteristics of chlorhexidine a series of N1-(p-chlorophenyl)-N5-alkylbiguanide acetates were synthesized. The anomalous sorption behaviour observed between PHEMA and the bis biguanide, chlorhexidine, was also found to be characteristic of these monofunctional biguanide derivatives. The extent of the interactions increased with increasing alkyl chain length (R = methyl to n-octyl), this being interpreted in terms of an interaction binding mechanism via the biguanide functional group stabilized by van der Waal's forces between the alkyl chain and the polymer backbone. Atypical sorption behaviour was observed for simple organic cations, biguanide and N1-phenylbiguanide acetate with PHEMA, a possible inference being that this is a general characteristic of all cationic sorption with PHEMA.

  关于溶质：塑料相互作用的总体观察表明，阳离子防腐剂氯己定的吸附与聚（2-羟基乙基甲基丙烯酸酯）（PHEMA）的吸附不仅是出乎意料的，而且在其性质上也是非典型的。研究了聚合物和防腐剂，发现PHEMA与简单溶质（即苯甲酸、苯佐卡因和苯胺）的吸附表现出常规性质。唯一的例外是在酸性pH下，苯佐卡因和苯胺阳离子的小量吸收。为了阐明氯己定的吸附特性，合成了一系列N1-（对氯苯基）-N5-烷基双胍醋酸盐。在PHEMA与双胍，氯己定之间的异常吸附行为也发现是这些单功能双胍衍生物的特征。随着烷基链长（R =甲基至正辛基）的增加，相互作用的程度增加，这被解释为通过双胍功能团介导的相互作用结合机制，该机制通过烷基链与聚合物主链之间的范德华力得到稳定。简单有机阳离子、双胍和N1-苯基双胍醋酸盐与PHEMA的吸附表现出非典型的吸附行为，可能的推断是这是所有阳离子与PHEMA吸附的一般特征。

• ANTIMICROBIAL AGENT FOR THE BIOCIDAL FINISH OF POLYMERS
  申请人：Wenatex Forschung - Entwicklung - Produktion GmbH

  公开号：US20170318813A1

  公开（公告）日：2017-11-09

  An antimicrobial agent for the biocidal finish of polymers based on biocides is described, whose molecules have at least one nitrogen atom with a free electron pair. In order to achieve an extensive insolubility without loss of the biocidal effect, it is proposed that the biocide is coordinatively bound to a metal complex via the free electron pair of the nitrogen atom.

  描述了一种用于基于生物杀菌剂的聚合物生物灭活整理的抗微生物剂，其分子至少具有一个带有自由电子对的氮原子。为了实现广泛的不溶性而不损失生物杀菌效果，建议通过氮原子的自由电子对将生物杀菌剂与金属配合物协同结合。
• Biguanide compositions and methods of treating metabolic disorders
  申请人：Elcelyx Therapeutics, Inc.

  公开号：US10028923B2

  公开（公告）日：2018-07-24

  Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.

  本文提供了通过施用包含双胍类或相关杂环化合物（如二甲双胍）的组合物来治疗某些疾病（包括糖尿病、肥胖症和其他代谢性疾病、失调或病症）的方法。本文还提供了双胍类或相关杂环化合物组合物及其用于本发明方法的制备方法。本文还提供了包含二甲双胍及其盐类的组合物和使用方法。
• Cleansing composition for skin or hair
  申请人：KAO CORPORATION

  公开号：US10196587B2

  公开（公告）日：2019-02-05

  The present invention provides a cleansing composition for skin or hair which can provide a good durability of foam and rinse feel, give good combability and softness from during rinsing to after drying while imparting manageability to hair when the cleansing composition is applied to hair, and give good moist feeling to skin when the cleansing composition is applied to skin. The cleansing composition for skin or hair is a cleansing composition comprising an internal olefin sulfonate (A) having 12 or more and 24 or less carbon atoms.

  本发明提供了一种用于皮肤或头发的清洁组合物，当该清洁组合物用于头发时，它能提供良好的泡沫持久性和冲洗感，从冲洗过程到干燥后都能提供良好的梳理性和柔软性，同时赋予头发可打理性，当该清洁组合物用于皮肤时，能给皮肤带来良好的湿润感。 用于皮肤或头发的清洁组合物是一种清洁组合物，它包含具有 12 个或更多和 24 个或更少碳原子的内烯烃磺酸盐（A）。
• Chlorhexidine-containing antimicrobial laminates
  申请人：McGuire, Jr. James E.

  公开号：US10314935B2

  公开（公告）日：2019-06-11

  Antimicrobial laminates of the invention include at least one adhesive layer; a backing outwardly exposed on a first side of the adhesive layer; and, optionally, a release liner outwardly exposed on a second side of the adhesive layer opposite from the first side of the adhesive layer. At least one of the at least one adhesive layer and the backing includes an antimicrobially effective amount of substantially pure chlorhexidine.

  本发明的抗菌层压板包括至少一个粘合剂层；在粘合剂层第一面向外露出的背衬；以及，可选地，在粘合剂层与粘合剂层第一面相对的第二面向外露出的离型衬垫。至少一个粘合剂层和背衬中的至少一个包括抗菌有效量的纯洗必泰。