Surfaces and coating compositions having antifouling, antithrombotic, and antibacterial properties and methods of making
申请人:University of Georgia Research Foundation, Inc.
公开号:US11370934B2
公开(公告)日:2022-06-28
Coating compositions, coated articles including the coating compositions, and methods of making the coating compositions and coated articles are provided. In some aspects, the coating compositions are applied to a substrate having nitric oxide-releasing properties. The coating compositions can include copolymers having crosslinking agents that can be activated with mild UV light (about 345 nm to 365 nm) to avoid damaging the substrate while creating strong covalent bonds to the substrate. The copolymers can include hydrophilic repeat units, and in particular zwitterionic repeat units such as repeat units containing phosphorylcholine groups. In some aspects, the coating compositions are applied to a surface of a polymer substrate, wherein the polymer substrate had nitric oxide releasing properties. The coating compositions and the coated articles can have antifouling, antithrombotic, and/or antibacterial properties.
本文提供了涂层组合物、包括涂层组合物的涂层制品以及制造涂层组合物和涂层制品的方法。在某些方面,涂层组合物适用于具有一氧化氮释放特性的基底。涂层组合物可以包括具有交联剂的共聚物,交联剂可以用温和的紫外线(约 345 纳米至 365 纳米)激活,以避免损坏基底,同时与基底形成强共价键。共聚物可以包括亲水性重复单元,特别是齐聚物重复单元,如含有磷酸胆碱基团的重复单元。在某些方面,将涂层组合物涂在聚合物基底的表面,其中聚合物基底具有释放一氧化氮的特性。涂层组合物和涂层物品可具有防污、抗血栓和/或抗菌特性。