3-(2,6-二甲基-4-吡啶基)-4-氟苯胺 | 104431-73-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 3-(2,6-二甲基-4-吡啶基)-4-氟苯胺
• 英文名称: 3-(2,6-dimethyl-4-pyridinyl)-4-fluorobenzeneamine
• 英文别名: 3-(2,6-dimethylpyridin-4-yl)-4-fluoroaniline
• CAS: 104431-73-4
• 化学式: C₁₃H₁₃FN₂
• 分子量: 216.258
• InChiKey: VYSKOXOMSHZQLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(2,6-二甲基-4-吡啶基)-4-氟苯胺 、 乙氧基甲叉丙二酸二乙酯 以 甲苯 为溶剂， 反应 3.5h， 以74%的产率得到二乙基2-[[[3-(2,6-二甲基吡啶-4-基)-4-氟苯基]氨基]亚甲基]丙二酸酯
  参考文献：
  名称：

  A novel, nonsteroidal inhibitor of androgen binding to the rat androgen binding protein: diethyl [[[3-(2,6-dimethyl-4-pyridinyl)-4-fluorophenyl]amino]methylene]propanedioate

  摘要：

  In vitro binding studies demonstrate the binding specificity of a series of 4-aryl-2,6-dimethylpyridines for the rat epididymal androgen binding protein (rABP). The compounds bound competitively to rABP but have very weak or no demonstrable affinity for rat ventral prostate androgen receptor and human sex hormone binding globulin. In particular, compound 11, diethyl [[[3-(2,6-dimethyl-4-pyridinyl)-4-fluorphenyl]amino]methylene] propanedioate, bound with high affinity to rABP (binding affinity about 1/3 that of the endogenous ligand 5 alpha-dihydrotestosterone). However, additional in vitro binding studies indicated that 11 did not bind to testicular or epididymal ABP from rabbit, rhesus monkey, and human. Nevertheless, the specificity and relatively high affinity of these nonsteroidal compounds make them unique and potentially ideal agents for the study of the role of ABP in spermatogenesis and sperm maturation in the rat.

  DOI：

  10.1021/jm00163a021
• 作为产物：
  描述：

  4-(2-Fluoro-5-nitrophenyl)-2,6-dimethylpyridine 以89%的产率得到
  参考文献：
  名称：

  WINNEKER, RICHARD C.;WAGNER, MARGARET M.;SINGH, BALDEV, J. MED. CHEM., 33,(1990) N, C. 129-132

  摘要：

  DOI：

文献信息

• Preparation of intermediates to
  申请人：Sterling Drug Inc.

  公开号：US04699984A1

  公开（公告）日：1987-10-13

  Shown is the process which comprises heating 4-(2-fluorophenyl)-2,6-dimethyl-3,5-pyridinedicarboxylic acid to produce a mixture of 4-(2-fluorophenyl)-2,6-dimethylpyridine and 2,4-dimethyl-5H-[1]benzopyrano[3,4-c]pyridin-5-one, separating the components of said mixture and nitrating 4-(2-fluorophenyl)-2,6-dimethylpyridine to produce 4-(2-fluoro-5-nitrophenyl)-2,6-dimethylpyridine. Also shown are the 3-step synthesis of 4-(2-fluorophenyl)-2,6-dimethyl-3,5-pyridinedicarboxylic acid from 2-fluorobenzaldehyde and the five step synthesis of 1-ethyl-6-fluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolin ecarboxylic acid, a highly potent antibacterial agent, starting with 4-(2-fluoro-5-nitrophenyl)-2,6-dimethylpyridine. Other intermediates shown in said five step synthesis include 3-(2,6-dimethyl-4-pyridinyl)-4-fluorobenzeneamine and diethyl 4-fluoro-3-(2,6-dimethyl-4-pyridinyl)anilinomethylenemalonate.

  该过程包括加热4-(2-氟苯基)-2,6-二甲基-3,5-吡啶二甲酸，产生4-(2-氟苯基)-2,6-二甲基吡啶和2,4-二甲基-5H-[1]苯并吡喃[3,4-c]吡啶-5-酮的混合物，分离该混合物的组分并对4-(2-氟苯基)-2,6-二甲基吡啶进行硝化，以产生4-(2-氟-5-硝基苯基)-2,6-二甲基吡啶。还展示了从2-氟苯甲醛合成4-(2-氟苯基)-2,6-二甲基-3,5-吡啶二甲酸的三步合成和从4-(2-氟-5-硝基苯基)-2,6-二甲基吡啶开始的1-乙基-6-氟-1,4-二氢-7-(2,6-二甲基-4-吡啶基)-4-氧-3-喹啉羧酸的五步合成，该化合物是一种高效的抗菌剂。在该五步合成中展示了其他中间体，包括3-(2,6-二甲基-4-吡啶基)-4-氟苯胺和二乙酸二乙酯4-氟-3-(2,6-二甲基-4-吡啶基)苯胺甲基亚甲基丙烯酸酯。
• 7-(Pyridinyl)-/-alkyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid having antibacterial activity and preparation thereof
  申请人：STERLING DRUG INC.

  公开号：EP0179239A2

  公开（公告）日：1986-04-30

  1-Ethyt-6-ftuoro-1,4-dihydro-7-(2,6-dimethy)-4-pyridinyt)-4-oxo-3-quinolinecarboxylic acid or salt thereof, a novel compound useful highly potent antibacterial agent with a broad spectrum of anti-microbial activity, is prepared by nitrating the corresponding 6-desfluoro compound to produce the corresponding 6-nitro compound, reducing the latter compound to produce the corresponding 6-amino compound and converting the 6-amino via its diazonium salt to said 6-fluoro compound. Said novel acid is also prepared via intermediates prepared by heating 4-(2-fluorophenyl)-2,6-dimethyl-3,5-pyridinedicarboxylic acid to produce a mixture of 4-(2-fluorophenyl)-2,6-di-methylpyridine and 2,4-dimethyl-5H-[1]benzopyrano[3,4-c)pyridin-5-one, separating the components of said mixture and nitrating 4-(2-fluorophenyl)-2,6-dimethylpyridine to produce 4-(2-fluoro-5-nitrophenyl)-2,6-dimethylpyridine.

  1-乙基-6-氟-1,4-二氢-7-(2,6-二甲基)-4-吡啶)-4-氧代-3-喹啉羧酸或其盐是一种新型化合物，是一种具有广谱抗微生物活性的高效抗菌剂、其制备方法是：硝化相应的 6-去氟化合物，生成相应的 6-硝基化合物；还原后者，生成相应的 6-氨基化合物；然后通过重氮盐将 6-氨基化合物转化为所述 6-氟化合物。所述新型酸也可以通过加热 4-(2-氟苯基)-2,6-二甲基-3,5-吡啶二羧酸生成 4-(2-氟苯基)-2,6-二甲基吡啶和 2、4-(2-氟苯基)-2,6-二甲基吡啶和 2,4-二甲基-5H-[1]苯并吡喃并[3,4-c]吡啶-5-酮的混合物，分离所述混合物的组分并硝化 4-(2-氟苯基)-2,6-二甲基吡啶，生成 4-(2-氟-5-硝基苯基)-2,6-二甲基吡啶。
• WINNEKER, RICHARD C.;WAGNER, MARGARET M.;SINGH, BALDEV, J. MED. CHEM., 33,(1990) N, C. 129-132
  作者：WINNEKER, RICHARD C.、WAGNER, MARGARET M.、SINGH, BALDEV

  DOI：——

  日期：——
• SINGH, BALDEV
  作者：SINGH, BALDEV

  DOI：——

  日期：——
• US4699984A
  申请人：——

  公开号：US4699984A

  公开（公告）日：1987-10-13