1,4-dimethyl-1,4-dihydropyridine | 57147-16-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1,4-dimethyl-1,4-dihydropyridine
• 英文别名: 1,4-Dihydro-1,4-dimethylpyridine；1,4-dimethyl-4H-pyridine
• CAS: 57147-16-7
• 化学式: C₇H₁₁N
• 分子量: 109.171
• InChiKey: RPEASIRIAKQFBC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,4-dimethyl-1,4-dihydropyridine 以47%的产率得到
  参考文献：
  名称：

  KONING A. J. DE; ALBERTS-JANSEN H. J.; BOERSMA J.; KERK G. J. M. VAN DER, REC. TRAV. CHIM. PAYS-BAS, 1980, 99, NO 10, 316-321

  摘要：

  DOI：
• 作为产物：
  描述：

  4-甲基吡啶 生成 1,4-dimethyl-1,4-dihydropyridine
  参考文献：
  名称：

  BIRCH A. J.; KARAKHANOV E. A., J. CHEM. SOC. CHEM. COMMUNS , 1975, NO 12, 480-481

  摘要：

  DOI：

文献信息

• Synthesis and NMR spectroscopic properties of some methyl-substituted 1-methyl-1,4-dihydropyridines
  作者：A.J. de Koning、P.H.M. Budzelaar、L. Brandsma、M.J.A. de Bie、J. Boersma

  DOI：10.1016/s0040-4039(00)71499-7

  日期：1980.1

  The synthesis and NMR spectroscopic properties of some methyl-substituted 1-methyl-1,4-dihydropyridines are described.

  描述了一些甲基取代的1-甲基-1,4-二氢吡啶的合成和NMR光谱性质。
• Novel dyes and compositions, and processes for using same in analysis of protein aggregation and other applications
  申请人：Patton Wayne Forrest

  公开号：US20110130305A1

  公开（公告）日：2011-06-02

  Provided are dyes and compositions which are useful in a number of applications, such as the detection and monitoring protein aggregation, kinetic studies of protein aggregation, neurofibrillary plaques analysis, evaluation of protein formulation stability, protein thermal stability shift assay and analysis of molecular chaperone activity. These dyes and compositions are also useful as probes in nucleic acid and protein detection.

  提供了染料和组合物，这些染料和组合物在许多应用中非常有用，例如检测和监测蛋白质聚集、蛋白质聚集的动力学研究、神经原纤维样斑块分析、评估蛋白质配方稳定性、蛋白质热稳定性位移测定和分子伴侣活性分析。这些染料和组合物也可作为核酸和蛋白质检测中的探针。
• [EN] NOVEL DYES FOR THE DETECTION OR QUANTIFICATION OF DESIRABLE TARGET MOLECULES<br/>[FR] NOUVEAUX COLORANTS POUR LA DÉTECTION OU LA QUANTIFICATION DE MOLÉCULES CIBLES SOUHAITABLES
  申请人：ENZO LIFE SCIENCES INC

  公开号：WO2009014513A1

  公开（公告）日：2009-01-29

  The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified to provide beneficial properties.

  本发明提供了染料、反应性染料和标记试剂，可用于检测或定量所需的目标分子，如蛋白质和核酸。所提供的染料可在溶液中自由使用，染料与目标分子的结合提供信号生成。还提供了包含反应性基团的染料，可用于将染料连接到将结合到所需目标分子的探针上。本发明的新型染料经过改性以提供有益性能。
• Labeling of target molecules, identification of organelles and other applications, novel compositions, methods and kits
  申请人：Pande Praveen

  公开号：US20090226954A1

  公开（公告）日：2009-09-10

  The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins, nucleic acids and cellular organelles. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified to provide beneficial properties.

  本发明提供染料、反应染料和标记试剂，可用于检测或定量所需的目标分子，如蛋白质、核酸和细胞器。提供了可在溶液中自由使用的染料，其中染料与目标分子的结合提供信号产生。还提供了包含反应基团的染料，可用于将染料附着到将结合到所需目标分子的探针上。本发明的新型染料已被改性以提供有益的性质。
• Methods and compositions of novel triazine compounds
  申请人：Timmer T. Richard

  公开号：US20070099874A1

  公开（公告）日：2007-05-03

  The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.

  本发明涉及用于治疗由炎症反应引起的病理生理状态的化合物的方法和组合物。特别地，本发明涉及抑制或阻断糖化蛋白诱导内皮细胞信号相关炎症反应的化合物。本发明涉及抑制平滑肌增殖的化合物。特别地，本发明涉及通过调节HSPG（如Perlecan）来抑制平滑肌细胞增殖的化合物。本发明进一步涉及使用化合物治疗由平滑肌增殖所特征的血管闭塞性疾病，例如再狭窄和动脉粥样硬化。