3-(2-(4-苯甲酰基苯氧基)乙酰氨基)苯甲酸 | 649773-81-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-(2-(4-苯甲酰基苯氧基)乙酰氨基)苯甲酸
• 英文名称: 3-[2-(4-benzoyl-phenoxy)-acetylamino]-benzoic acid
• 英文别名: 3-[2-(4-Benzoylphenoxy)acetamido]benzoic acid；3-[[2-(4-benzoylphenoxy)acetyl]amino]benzoic acid
• CAS: 649773-81-9
• 化学式: C₂₂H₁₇NO₅
• 分子量: 375.381
• InChiKey: CHGVLAFQXKESOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  92.7
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Acetylamino benzoic acid compounds and their use for nonsense suppression and the treatment of disease
  申请人：Wilde G. Richard

  公开号：US20060167263A1

  公开（公告）日：2006-07-27

  Novel acetylamino benzoic acid compounds, methods of using and pharmaceutical compositions comprising an acetylamino benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.

  揭示了一种新的乙酰氨基苯甲酸化合物，使用方法以及包括乙酰氨基苯甲酸衍生物的药物组合物。这些方法包括治疗或预防通过调节过早翻译终止或无义介导的mRNA降解而改善的疾病的方法，或改善与之相关的一个或多个症状。
• Use of acetylamino benzoic acid compounds for nonsense suppression and the treatment of disease
  申请人：Wilde G. Richard

  公开号：US20070203123A1

  公开（公告）日：2007-08-30

  Novel acetylamino benzoic acid compounds, methods of using and pharmaceutical compositions comprising an acetylamino benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.

  本发明揭示了新型乙酰氨基苯甲酸衍生物化合物、使用方法和包含乙酰氨基苯甲酸衍生物的制药组合物。该方法包括治疗或预防通过调节早期翻译终止或无意义介导的mRNA降解而改善的疾病，或改善与之相关的一个或多个症状的方法。
• METHODS FOR THE PRODUCTION OF FUNCTIONAL PROTEIN FROM DNA HAVING A NONSENSE MUTATION AND THE TREATMENT OF DISORDERS ASSOCICATED THEREWITH
  申请人：Almstead Neil G.

  公开号：US20110046136A1

  公开（公告）日：2011-02-24

  The present invention relates to functional proteins encoded by nucleic acid sequences comprising a nonsense mutation. The present invention also relates to methods for the production of functional proteins encoded by nucleic acid sequences comprising a nonsense mutation and the use of such proteins for prevention, management and/or treatment of diseases associated with a nonsense mutation(s) in a gene.

  本发明涉及由核酸序列编码的功能性蛋白质，其中包括一个无意义突变。本发明还涉及用于生产由包含无意义突变的核酸序列编码的功能性蛋白质的方法，以及利用这些蛋白质预防、管理和/或治疗与基因中的无意义突变相关的疾病。
• METHODS FOR THE PRODUCTION OF FUNCTIONAL PROTEIN FROM DNA HAVING A NONSENSE MUTATION AND THE TREATMENT OF DISORDERS ASSOCIATED THEREWITH
  申请人：PTC THERAPEUTICS, INC

  公开号：US20160199357A1

  公开（公告）日：2016-07-14

  The present invention relates to functional proteins encoded by nucleic acid sequences comprising a nonsense mutation. The present invention also relates to methods for the production of functional proteins encoded by nucleic acid sequences comprising a nonsense mutation and the use of such proteins for prevention, management and/or treatment of diseases associated with a nonsense mutation(s) in a gene.

  本发明涉及由包含无意义突变的核酸序列编码的功能蛋白质。本发明还涉及用于生产由包含无意义突变的核酸序列编码的功能蛋白质的方法，并使用这些蛋白质预防、管理和/或治疗与基因中的无意义突变相关的疾病。
• US7247741B2
  申请人：——

  公开号：US7247741B2

  公开（公告）日：2007-07-24