7-Chlor-[2]naphthylamin | 90799-47-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 7-Chlor-[2]naphthylamin
• 英文别名: 7-Chlor-2-amino-naphthalin；7-Chloronaphthalen-2-amine
• CAS: 90799-47-6
• 化学式: C₁₀H₈ClN
• 分子量: 177.633
• InChiKey: CXRIRBFSNTZALG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  7-Chlor-[2]naphthylamin 在 硫酸 、 溶剂黄146 作用下， 生成 2-氯-7-羟基萘
  参考文献：
  名称：

  A Prospective Study of Health Symptoms AndAspergillus fumigatusSpore Counts Near a Grass and Leaf Composting Facility

  摘要：

  DOI：

  10.1080/1065657x.2001.10702041
• 作为产物：
  描述：

  2,7-萘二磺酰氯 在 氢氧化钾 、 ammonium hydroxide 、 氯化亚砜 、 亚硫酸氢铵 、 乙醇 、 铜 、 过氧化苯甲酰 作用下， 以 四氯化碳 为溶剂， 生成 7-Chlor-[2]naphthylamin
  参考文献：
  名称：

  某些杂核一氯和二氯-2-萘胺的合成

  摘要：

  描述了分别由2-萘酚-6-磺酸钠和萘-2,7-二磺酸二钠制备6-氯和7-氯-2-萘胺的改进方法。还报道了5，6-，5，7-和6，7-二氯-2-萘胺的合成。

  DOI：

  10.1039/j39690001376

文献信息

• Synthesis of Aryl Amine Derivatives from Benzyl Nitriles via Electrocyclization of in Situ Generated <i>N</i>-Silyl Ketene Imines
  作者：Fumihiko Yoshimura、Taiki Abe、Keiji Tanino

  DOI：10.1021/acs.orglett.6b00490

  日期：2016.4.1

  N-silyl ketene imines in organic synthesis is reported. Benzyl nitriles containing an alkenyl or aryl group at the ortho position were smoothly converted into aryl amines in good yields under two sets of mild silylation conditions: (1) nonbasic conditions using TMSNTf2–iPr2NEt or (2) basic anionic conditions using lithium diisopropylamide–triisopropylsilyl chloride (LDA–TIPSCl). The reaction probably proceeds

  据报道，在有机合成中，N-甲硅烷基烯酮亚胺的反应性尚未得到开发。在两组温和的甲硅烷基化条件下，邻位含有烯基或芳基的苄腈可以高收率平稳地转化为芳基胺：（1）使用TMSNTf 2 – i Pr 2 NEt的非碱性条件或（2）使用TMSNTf 2 – i Pr 2 NEt的非碱性条件二异丙基氨基锂–三异丙基氯硅烷（LDA–TIPSCl）。该反应可能通过原位产生N-甲硅烷基烯酮亚胺，然后进行6π-电环化和芳构化来进行。
• Neurocognitive Symptoms and Impairment in an HIV Community Clinic
  作者：D.H. Kim、C. Power、M.J. Gill、D.L. Jewison、G.R. Milner、S.B. Rourke

  DOI：10.1017/s0317167100001372

  日期：2001.8

  Neurocognitive impairment is a frequent complication of HIV infection and heralds a poor survival prognosis. With the availability of highly active antiretroviral therapy (HAART), survival times for HIV-infected patients have markedly increased although the effects of HAART on the prevalence of neurocognitive impairment remain uncertain.

  To determine the relationship between self-reported neurocognitive symptoms and neuropsychological (NP) performance together with the impact of HAART among HIV-infected patients.

  A cross-sectional study was performed in which patients without previously documented neurocognitive impairment attending an HIV community clinic were questioned about neurocognitive symptoms and a NP test battery was administered.

  Of the eighty-three patients examined, neurocognitive symptoms were reported by 34% of patients and were associated with a shorter duration of HAART and higher viral loads. Patients reporting neurocognitive symptoms were also more likely to exhibit impaired NP performance (p<0.005) with NP impairment being detected in 46% of all patients examined (12% with HIV-associated dementia). Neuropsychological impairment was directly correlated with age (p<0.001), plasma viral load (p<0.005) and inversely correlated with the number of prescribed antiretroviral drugs (p<0.01).

  These results suggest that neurocognitive symptoms are predictive of impaired NP performance and that NP impairment remains a frequent finding among older patients with higher viral loads. An increased number of antiretroviral drugs may be neuroprotective.

  背景：神经认知障碍是艾滋病病毒感染的常见并发症，预示着不良的生存预后。随着高效抗逆转录病毒疗法（HAART）的出现，艾滋病病毒感染者的生存时间明显延长，但HAART对神经认知障碍发生率的影响仍不确定。目的：确定艾滋病病毒感染者自我报告的神经认知症状与神经心理学（NP）表现之间的关系以及HAART的影响。结果：在接受检查的 83 名患者中，有 34% 的患者报告了神经认知症状，这些症状与较短的 HAART 持续时间和较高的病毒载量有关。报告有神经认知症状的患者也更有可能表现出NP功能受损（p<0.005），在所有受检患者中，46%的患者（12%患有HIV相关性痴呆）发现了NP功能受损。神经心理障碍与年龄（p<0.001）、血浆病毒载量（p<0.005）直接相关，与处方抗逆转录病毒药物的数量成反比（p<0.01）。更多的抗逆转录病毒药物可能具有神经保护作用。
• HETEROCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE COMPRISING SAME
  申请人：LG CHEM, LTD.

  公开号：US20200048226A1

  公开（公告）日：2020-02-13

  The present specification relates to a heterocyclic compound of Chemical Formula 1, and an organic light emitting device comprising the same. The heterocyclic compound as a material of an organic material layer of the organic light emitting device provides enhanced efficiency, low driving voltage and increased lifetime.

  本规范涉及化学式1的杂环化合物，以及包含该化合物的有机发光器件。作为有机发光器件有机材料层的材料，这种杂环化合物提供了增强效率、低驱动电压和延长寿命的特性。
• CARBAZOLE-BASED COMPOUND AND ORGANIC LIGHT EMITTING DIODE COMPRISING SAME
  申请人：LG CHEM, LTD.

  公开号：EP3677580A1

  公开（公告）日：2020-07-08

  The present application relates to a compound of Chemical Formula 1, and an organic light emitting device comprising same.

  本申请涉及一种化学式 1 的化合物，以及包含该化合物的有机发光器件。
• Heterocyclic compound and organic light-emitting device comprising same
  申请人：LG CHEM, LTD.

  公开号：US11192884B2

  公开（公告）日：2021-12-07

  The present specification relates to a heterocyclic compound of Chemical Formula 1, and an organic light emitting device comprising the same. The heterocyclic compound as a material of an organic material layer of the organic light emitting device provides enhanced efficiency, low driving voltage and increased lifetime.

  本说明书涉及一种化学式 1 的杂环化合物，以及包含该杂环化合物的有机发光器件。杂环化合物作为有机发光器件有机材料层的材料，可提高效率、降低驱动电压并延长使用寿命。