N,N'-bis-(5-chloro-[2]pyridyl)-formamidine | 23595-76-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N,N'-bis-(5-chloro-[2]pyridyl)-formamidine
• 英文别名: N,N'-Bis-(5-chlor-[2]pyridyl)-formamidin；N,N'-Bis-(5-chlor-pyridyl-2)-formamidin；N,N'-bis(5-chloropyridin-2-yl)methanimidamide
• CAS: 23595-76-8
• 化学式: C₁₁H₈Cl₂N₄
• 分子量: 267.117
• InChiKey: HWYCLBWSZBHOJR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N,N'-bis-(5-chloro-[2]pyridyl)-formamidine 、 1-ethyl-4-methylpyridinium iodide 生成 1-ethyl-4-[2-(5-chloro-[2]pyridylamino)-vinyl]-pyridinium; iodide
  参考文献：
  名称：

  Takahashi et al., Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1954, vol. 74, p. 1212,1214

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氨基-5-氯吡啶 、 原甲酸三乙酯 生成 N,N'-bis-(5-chloro-[2]pyridyl)-formamidine
  参考文献：
  名称：

  Takahashi et al., Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1944, vol. 64, # 11, p. 55

  摘要：

  DOI：

文献信息

• Takahashi et al., Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1949, vol. 69, p. 144
  作者：Takahashi et al.

  DOI：——

  日期：——
• Takahashi; Satake, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1951, vol. 71, p. 426,429
  作者：Takahashi、Satake

  DOI：——

  日期：——
• Takahashi; Satake, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1953, vol. 73, p. 222,223
  作者：Takahashi、Satake

  DOI：——

  日期：——
• Telomerase inhibitors
  作者：Laura K. White、Woodring E. Wright、Jerry W. Shay

  DOI：10.1016/s0167-7799(00)01541-9

  日期：2001.3

  There has been a vast increase in telomerase research over the past several years, with many different pre-clinical approaches being tested for inhibiting the activity of this enzyme as a novel therapeutic modality to treat malignancy. In this review, we will provide some basic background information about telomeres and telomerase and then discuss the pros, cons and challenges of the approaches that are currently under investigation, and what we might expect in the future of this emerging field.
• Takahashi et al., Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1944, vol. 64, # 11, p. 55
  作者：Takahashi et al.

  DOI：——

  日期：——