4-(3-aminophenyl)-1-butanol | 620601-06-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(3-aminophenyl)-1-butanol
• 英文别名: 4-(3-aminophenyl)butan-1-ol
• CAS: 620601-06-1
• 化学式: C₁₀H₁₅NO
• 分子量: 165.235
• InChiKey: PLRNILGQCHPXKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(3-aminophenyl)-1-butanol 、 氯乙基异氰酸酯 以 二氯甲烷 为溶剂， 反应 20.0h， 以41%的产率得到1-(2-氯乙基)-3-[3-(4-羟基丁基)苯基]脲
  参考文献：
  名称：

  Optimized N-phenyl-N′-(2-chloroethyl)ureas as potential antineoplastic agents: Synthesis and growth inhibition activity

  摘要：

  In our ongoing research program aimed at the optimization of microtubule-self-assembly disrupting agents, we have prepared three series of phenylurea analogues (CEU), derived from N-(3-omega-hydroxyalkyl or 4-omega-hydroxyalkyl or 3-omega-hydroxyalkynyl)phenyl-N'-(2-chloroethyl)ureas. Most compounds exhibit potent growth inhibitory activity on human colon carcinoma HT-29, human skin melanoma M21, and human breast carcinoma MCF-7 tumor cell lines, with a GI(50) ranging from 250 nM to 8 mu M. Among these new molecules, three CEUs exhibit GI(50) in the nanomolar range. They are more potent by approximately an order of magnitude than previously described CEU analogues. As such, they are attractive hit compounds for the development of potent new alkylating antitubulin drugs. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.07.048

文献信息

• [EN] PHENETHANOLAMINE DERIVATIVES<br/>[FR] DERIVES DE LA PHENETHANOLAMINE
  申请人：GLAXO GROUP LTD

  公开号：WO2003091204A1

  公开（公告）日：2003-11-06

  The present invention relates to novel compounds of formula (I), or a salt, solvate, or physiologically functional derivative thereof, to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.

  本发明涉及式(I)的新化合物，或其盐、溶剂合物或生理功能衍生物，以及其制备方法，含有它们的药物组合物，以及它们在治疗中的应用，特别是在预防和治疗呼吸道疾病中的应用。
• [EN] HALOETHYL UREA COMPOUNDS AND THEIR USE TO ATTENUATE, INHIBIT OR PREVENT NON-CANCEROUS PATHOGENIC CELLULAR PROLIFERATION AND DISEASES ASSOCIATED THEREWITH<br/>[FR] COMPOSES D'UREE HALOETHYLE ET LEUR UTILISATION EN VUE D'ATTENUER, D'INHIBER OU DE PREVENIR LA PROLIFERATION CELLULAIRE PATHOGENE NON CANCEREUSE ET LES MALADIES Y ETANT ASSOCIEES
  申请人：IMOTEP INC

  公开号：WO2004106292A1

  公开（公告）日：2004-12-09

  The present invention provides haloethyl urea compounds as described in Formula (I) and their use as anti-proliferative agent in the attenuation, inhibition, or prevention of non-cancerous cellular proliferation. These compounds are also provided for use as a therapeutic agent in the treatment of a disease or disorder, wherein pathogenesis of said disease or disorder is associated with non-cancerous pathogenic cellular proliferation.

  本发明提供了如公式(I)所述的卤乙基脲化合物，以及它们作为抗增殖剂在减轻、抑制或预防非癌细胞增殖中的用途。这些化合物还可用作治疗剂，用于治疗与非癌病理性细胞增殖相关的疾病或障碍，其中该疾病或障碍的发病机制与非癌病理性细胞增殖有关。
• [EN] HALOETHYL UREA COMPOUNDS AND THE USE THEREOF TO ATTENUATE, INHIBIT OR PREVENT CANCER CELL MIGRATION<br/>[FR] COMPOSES D'UREE HALOETHYLE ET LEUR UTILISATION EN VUE D'ATTENUER, D'INHIBER OU DE PREVENIR LA MIGRATION DE CELLULES CANCEREUSES
  申请人：IMOTEP INC

  公开号：WO2004106291A1

  公开（公告）日：2004-12-09

  The present invention provides haloethyl urea compounds as described in Formula (I) and their use as therapeutic agent in the attenuation, inhibition, or prevention of cancer cell migration and cancer cell proliferation.

  本发明提供了如公式(I)所述的卤乙基脲化合物，并将其用作治疗剂，用于减轻、抑制或预防癌细胞迁移和癌细胞增殖。
• [EN] PHENETANOLAMINE DERIVATIVES<br/>[FR] DERIVES DE PHENETANOLAMINE
  申请人：GLAXO GROUP LTD

  公开号：WO2005044787A1

  公开（公告）日：2005-05-19

  Compounds of formula (I) and salts, solvates, and physiologically functional derivatives thereof, useful for the prophylaxis or treatment of a clinical condition for which a selective β2-adrenoreceptor agonist is indicated, for example asthma or chronic obstructive pulmonary disease (COPD).

  化合物的化学式(I)及其盐、溶剂合物和生理功能衍生物，可用于预防或治疗需要选择性β2-肾上腺素受体激动剂的临床病症，例如哮喘或慢性阻塞性肺疾病（COPD）。
• Phenethanolamine derivatives
  申请人：Box Charles Philip

  公开号：US20050256201A1

  公开（公告）日：2005-11-17

  The present invention relates to novel compounds of formula (I), or a salt, solvate, or physiologically functional derivative thereof, to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.

  本发明与公式（I）的新化合物有关，或其盐，溶剂合物或生理功能衍生物，以及其制造过程，包含它们的制药组合物，并且它们在治疗中的使用，特别是在呼吸系统疾病的预防和治疗中的使用。