3-(2-氧咪唑烷-1-基)苯甲酸 | 884504-86-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 中文名称: 3-(2-氧咪唑烷-1-基)苯甲酸
• 英文名称: 3-(2-Oxoimidazolidin-1-yl)benzoic acid
• CAS: 884504-86-3
• 化学式: C₁₀H₁₀N₂O₃
• mdl: MFCD05864567
• 分子量: 206.2
• InChiKey: REVYTXLGZSYHEG-UHFFFAOYSA-N

物化性质

• 密度：
  1.383±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  69.6
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2933990090

文献信息

• PROTEASOME INHIBITORS AND USES THEREOF
  申请人：CORNELL UNIVERSITY

  公开号：US20180282317A1

  公开（公告）日：2018-10-04

  The compounds of the present invention are represented by the following compounds having Formula (I) where the substituents R, R 1 -R 5 , k, m, n, and q are as defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders, infectious disease, or for providing immunosuppression for transplanted organs or tissues.

  本发明的化合物由具有以下式（I）的化合物表示，其中取代基R，R1-R5，k，m，n和q如本文所定义。这些化合物用于治疗癌症、免疫紊乱、自身免疫紊乱、神经退行性疾病、炎症性疾病、传染病，或为移植的器官或组织提供免疫抑制。
• ARYL CARBOXAMIDE DERIVATIVES AS TTX-S BLOCKERS
  申请人：Yamagishi Tatsuya

  公开号：US20120232052A1

  公开（公告）日：2012-09-13

  The present invention relates to aryl carboxamide derivatives of formula (I), wherein Ar 1 is phenyl; Ar 2 is aryl; n is 1-4; X is —O—, —S—, —SO— or —SO 2 —, a prodrug thereof or a pharmaceutically acceptable salt thereof, which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of such disorders and diseases as pain in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases as pain in which voltage gated sodium channels are involved.

  本发明涉及公式（I）的芳基羧酰胺衍生物，其中Ar1是苯基；Ar2是芳基；n为1-4；X为—O—、—S—、—SO—或—SO2—，其前体药物或其药学上可接受的盐，具有阻断电压门控钠通道如TTX-S通道的活性，并在治疗或预防涉及电压门控钠通道的疾病和疾病，如疼痛方面中有用。本发明还涉及包含这些化合物的制药组合物以及这些化合物和组合物在预防或治疗涉及电压门控钠通道的疾病和疾病，如疼痛方面的使用。
• Proteasome inhibitors and uses thereof
  申请人：CORNELL UNIVERSITY

  公开号：US11066397B2

  公开（公告）日：2021-07-20

  The compounds of the present invention are represented by the following compounds having Formula (I) where the substituents R, R1-R5, k, m, n, and q are as defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders, infectious disease, or for providing immunosuppression for transplanted organs or tissues.

  本发明的化合物由以下具有式（I）的化合物表示，其中取代基 R、R1-R5、k、m、n 和 q 如本文所定义。这些化合物可用于治疗癌症、免疫性疾病、自身免疫性疾病、神经退行性疾病或炎症性疾病、传染性疾病，或为移植器官或组织提供免疫抑制。
• MASP INHIBITORY COMPOUNDS AND USES THEREOF
  申请人：Bayer Aktiengesellschaft

  公开号：US20210246166A1

  公开（公告）日：2021-08-12

  The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory compounds, as well as analogues and derivatives thereof, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries.
• US9051296B2
  申请人：——

  公开号：US9051296B2

  公开（公告）日：2015-06-09