3-acetyl-1-methyl-5-nitro-4,6-diphenylpyridin-2(1H)-one | 929008-42-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-acetyl-1-methyl-5-nitro-4,6-diphenylpyridin-2(1H)-one
• 英文别名: 3-acetyl-1-methyl-5-nitro-4,6-diphenyl-2-pyridone；2(1H)-Pyridinone, 3-acetyl-1-methyl-5-nitro-4,6-diphenyl-；3-acetyl-1-methyl-5-nitro-4,6-diphenylpyridin-2-one
• CAS: 929008-42-4
• 化学式: C₂₀H₁₆N₂O₄
• 分子量: 348.358
• InChiKey: PUCLMKAATIHRAW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  83.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  ethyl 1,2-dimethyl-5-nitro-4,6-diphenylpyridin-1-ium-3-carboxylate;methyl sulfate 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以42%的产率得到ethyl 5'-methylamino-2'-nitro-1,1':3',1''-terphenyl-4'-carboxylate
  参考文献：
  名称：

  Nitropyridines: III. Synthesis of meta-terphenyls by recyclization of nitropyridinium salts

  摘要：

  A two-component Hantzsch synthesis was applied to preparation of nitropyridines and their quaternary salts from various enamines and chalcones based on nitroacetophenone. The recyclization of nitropyridinium quaternary salts under the treatment with an aqueous-alcoholic alkali led to preparation of 5'-methylamino-2'-nitro-m-terphenyl derivatives.

  DOI：

  10.1134/s1070428006080173

文献信息

• Nitropyridines: III. Synthesis of meta-terphenyls by recyclization of nitropyridinium salts
  作者：G. P. Sagitullina、L. V. Glidzinskaya、R. S. Sagitullin

  DOI：10.1134/s1070428006080173

  日期：2006.8

  A two-component Hantzsch synthesis was applied to preparation of nitropyridines and their quaternary salts from various enamines and chalcones based on nitroacetophenone. The recyclization of nitropyridinium quaternary salts under the treatment with an aqueous-alcoholic alkali led to preparation of 5'-methylamino-2'-nitro-m-terphenyl derivatives.