N¹-(2,6-dimethylphenyl)-N²-(diphenylmethylene)glycinamide | 614718-88-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N¹-(2,6-dimethylphenyl)-N²-(diphenylmethylene)glycinamide
• 英文别名: Acetamide, N-(2,6-dimethylphenyl)-2-[(diphenylmethylene)amino]-；2-(benzhydrylideneamino)-N-(2,6-dimethylphenyl)acetamide
• CAS: 614718-88-6
• 化学式: C₂₃H₂₂N₂O
• 分子量: 342.44
• InChiKey: KQFHBZIMSMKKMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  41.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  二苯甲酮亚胺 、 甘氨酸二甲苯胺盐酸盐 以82%的产率得到N¹-(2,6-dimethylphenyl)-N²-(diphenylmethylene)glycinamide
  参考文献：
  名称：

  Phase transfer catalyzed asymmetric alkylations of imine glycinamides

  摘要：

  Herein we report the use of achiral imine glycinamides as substrates for asymmetric alkylations using chiral phase-transfer catalysts for the first time. Initially tried for obtaining a key intermediate for the synthesis of levobupivacaine, we expanded the study to other N-mono and N,N-disubstituted imine glycinamides. A possible explanation for the lower enantioselectivity observed in the ease of alkylation of N-monosubstituted as compared to N,N-disubstituted glycinamides is also provided. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(03)00441-5