(R)-(-)-methyl 2,7-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylate | 208342-11-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: (R)-(-)-methyl 2,7-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylate
• 英文别名: methyl (2R)-2,7-dimethyl-3-oxo-4H-1,4-benzoxazine-2-carboxylate
• CAS: 208342-11-4
• 化学式: C₁₂H₁₃NO₄
• 分子量: 235.24
• InChiKey: KHCFDWOOBRAACY-GFCCVEGCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (R)-(-)-methyl 2,7-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylate 在 sodium hydroxide 作用下， 以 1,4-二氧六环 为溶剂， 生成 (R)-(-)-2,7-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid
  参考文献：
  名称：

  Enantioselective synthesis of (R)- and (S)-2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxamides

  摘要：

  Enantiomers of 2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxamides bearing different substituents in the aromatic ring are obtained by the cyclization of (R)-monomethyl 2-methyl-2-(2-nitrophenoxy)malonates with the participation of the carboxy and methoxycarbonyl group, respectively. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(98)00082-2
• 作为产物：
  描述：

  (R)-2-Methyl-2-(5-methyl-2-nitro-phenoxy)-malonic acid monomethyl ester 在 palladium on activated charcoal 氢气 作用下， 以 氯仿 为溶剂， 反应 24.0h， 生成 (R)-(-)-methyl 2,7-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylate
  参考文献：
  名称：

  Stereoselective synthesis of (R)- and (S)-2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acids, -carboxylates and -carboxamides

  摘要：

  (R)-Monomethyl 2-methyl-2-(2- nitrophenoxy)malonates obtained by PLE catalyzed hydrolysis of the corresponding dimethyl malonates undergo solvent-dependent enantioselective cyclization to afford (R)-methyl 2-methyl-3-oxo-3,4-dihydro-2H-1,4-hentoxazine-2-carboxylates and (S)-2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxyIic acids, respectively. These compounds are easily converted to enantiomerically and diastereomerically pure carboxamides, which are used as peptidomimetic building blocks. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(98)00485-6

文献信息

• Enantioselective synthesis of (R)- and (S)-2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxamides
  作者：Matej Breznik、Alenka Mrcina、Danijel Kikelj

  DOI：10.1016/s0957-4166(98)00082-2

  日期：1998.4

  Enantiomers of 2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxamides bearing different substituents in the aromatic ring are obtained by the cyclization of (R)-monomethyl 2-methyl-2-(2-nitrophenoxy)malonates with the participation of the carboxy and methoxycarbonyl group, respectively. (C) 1998 Elsevier Science Ltd. All rights reserved.
• Stereoselective synthesis of (R)- and (S)-2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acids, -carboxylates and -carboxamides
  作者：Matej Breznik、Valentina Hrast、Alenka Mrcina、Danijel Kikelj

  DOI：10.1016/s0957-4166(98)00485-6

  日期：1999.1

  (R)-Monomethyl 2-methyl-2-(2- nitrophenoxy)malonates obtained by PLE catalyzed hydrolysis of the corresponding dimethyl malonates undergo solvent-dependent enantioselective cyclization to afford (R)-methyl 2-methyl-3-oxo-3,4-dihydro-2H-1,4-hentoxazine-2-carboxylates and (S)-2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxyIic acids, respectively. These compounds are easily converted to enantiomerically and diastereomerically pure carboxamides, which are used as peptidomimetic building blocks. (C) 1999 Elsevier Science Ltd. All rights reserved.