N-cyclohexyl-2-((4-oxo-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetamide | 536703-68-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并嘧啶类
• 英文名称: N-cyclohexyl-2-((4-oxo-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetamide
• 英文别名: N-cyclohexyl-2-[(4-oxo-3-phenyl-5H-pyrimido[5,4-b]indol-2-yl)sulfanyl]acetamide
• CAS: 536703-68-1
• 化学式: C₂₄H₂₄N₄O₂S
• 分子量: 432.546
• InChiKey: DLVOJMMGVBQRBW-UHFFFAOYSA-N

物化性质

• 密度：
  1.39±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-cyclohexyl-2-((4-oxo-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetamide 、 (2E)-TCO-PNB ester 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 0.67h， 生成 cyclooct-2-en-1-yl 2-[2-(cyclohexylamino)-2-oxoethyl]sulfanyl-4-oxo-3-phenylpyrimido[5,4-b]indole-5-carboxylate
  参考文献：
  名称：

  [EN] TETRAZINES FOR HIGH CLICK CONJUGATION YIELD IN VIVO AND HIGH CLICK RELEASE YIELD
  [FR] TÉTRAZINES POUR UN RENDEMENT ÉLEVÉ DE CONJUGAISON DE CHIMIE CLICK IN VIVO ET UN RENDEMENT ÉLEVÉ DE LIBÉRATION DE CHIMIE CLICK

  摘要：

  公开号：

  WO2019212356A8
• 作为产物：
  描述：

  3-氨基-2-吲哚羧酸乙酯 在 三乙胺 、 乙酰氯 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 、 potassium hydroxide 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 24.33h， 生成 N-cyclohexyl-2-((4-oxo-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetamide
  参考文献：
  名称：

  Identification of Substituted Pyrimido[5,4-b]indoles as Selective Toll-Like Receptor 4 Ligands

  摘要：

  A cell-based high-throughput screen to identify small molecular weight stimulators of the innate immune system revealed substituted pyrimido[5,4-b]indoles as potent NF kappa beta activators. The most potent hit compound selectively stimulated Toll-like receptor 4 (TLR4) in human and mouse cells. Synthetic modifications of the pyrimido[5,4-b]indole scaffold at the carboxamide, N-3, and N-5 positions revealed differential TLR4 dependent production of NF kappa beta and type I interferon associated cytokines, IL-6 and interferon gamma-induced protein 10 (IP-10) respectively. Specifically, a subset of compounds bearing phenyl and substituted phenyl carboxamides induced lower IL-6 release while maintaining higher IP-10 production, skewing toward the type I interferon pathway. Substitution at N-5 with short alkyl substituents reduced the cytotoxicity of the leading hit compound. Computational studies supported that active compounds appeared to bind primarily to MD-2 in the TLR4/MD-2 complex. These small molecules, which stimulate innate immune cells with minimal toxicity, could potentially be used as adjuvants or immune modulators.

  DOI：

  10.1021/jm301694x

文献信息

• COMPOSITIONS AND METHODS FOR MODULATING TLR4
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20150197527A1

  公开（公告）日：2015-07-16

  Provided herein, inter alia, are methods and compositions for modulating TLR-4.

  本文提供了一些调节TLR-4的方法和组合物。
• TETRAZINES FOR HIGH CLICK CONJUGATION YIELD IN VIVO AND HIGH CLICK RELEASE YIELD
  申请人：Tagworks Pharmaceuticals B.V.

  公开号：EP3787691A1

  公开（公告）日：2021-03-10
• SYNTHETIC TLR4 AND TLR7 LIGANDS TO PREVENT, INHIBIT OR TREAT LIVER DISEASE
  申请人：The Regents of the University of California

  公开号：US20180110784A1

  公开（公告）日：2018-04-26

  Methods of using TLR7 conjugates or TLR4 ligands, or a combination thereof, to treat fibrosis are provided.
• US9505768B2
  申请人：——

  公开号：US9505768B2

  公开（公告）日：2016-11-29